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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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1437-4331
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Volume 49, Issue 11 (Nov 2011)

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Plasma symmetric dimethylarginine reference limits from the Framingham offspring cohort

Edzard Schwedhelm
  • Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
/ Vanessa Xanthakis
  • Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
  • Framingham Heart Study, Framingham, MA, USA
  • Preventive Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
/ Renke Maas
  • Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen, Erlangen, Germany
/ Lisa M. Sullivan
  • Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
  • Framingham Heart Study, Framingham, MA, USA
/ Dorothee Atzler
  • Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
/ Nicole Lüneburg
  • Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
/ Nicole L. Glazer
  • Framingham Heart Study, Framingham, MA, USA
  • Preventive Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
/ Ulrich Riederer
  • Institute of Pharmacy, University of Hamburg, Hamburg, Germany
/ Ramachandran S. Vasan
  • Framingham Heart Study, Framingham, MA, USA
  • Preventive Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
  • Cardiology Sections, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
/ Rainer H. Böger
  • Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Published Online: 2011-08-25 | DOI: https://doi.org/10.1515/cclm.2011.679

Abstract

Background: Symmetric dimethylarginine (SDMA) is a by-product of protein methylation. Once released from proteins, SDMA is eliminated by the kidneys; consequently, plasma concentration has been suggested as a sensitive marker of renal function. Furthermore, recent work implicates SDMA in the pathogenesis of cardiovascular disease. To date, reference limits for SDMA plasma concentrations in healthy individuals are lacking.

Methods: This study defined reference limits for plasma SDMA concentrations in 840 relatively healthy individuals of the Offspring Cohort from Framingham Heart Study (mean age 56 years, 61% women). Plasma SDMA concentrations were determined by LC-MS/MS using a stable isotope dilution assay.

Results: The median SDMA concentration in the reference sample was 0.37 μmol/L (Q1, Q3:0.32, 0.43 μmol/L) and the reference limits were 0.225 and 0.533 (2.5th and 97.5th percentile). In a multivariable regression model, serum creatinine, age and total homocysteine were positively associated with SDMA (p<0.001 for all), whereas the body mass index and diastolic blood pressure were inversely related to SDMA (p-values<0.01 and 0.03, respectively).

Conclusions: This study reports plasma SDMA reference limits from the community-based Framingham Heart Study. Plasma SDMA concentration was related positively to advancing age, but inversely to renal function. These reference limits may allow the identification of individuals with raised plasma SDMA concentrations.

Keywords: Framingham Heart Study; LC-MS/MS; symmetric dimethylarginine

About the article

Corresponding author: Edzard Schwedhelm, Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany Fax: 49-40-741059757


Received: 2011-04-05

Accepted: 2011-07-26

Published Online: 2011-08-25

Published in Print: 2011-11-01



Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm.2011.679. Export Citation

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