Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year

IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

See all formats and pricing
More options …
Volume 49, Issue 3 (Mar 2011)


α-Synuclein in Parkinson disease and other neurodegenerative disorders

Michael Eller / David R. Williams
  • Department of Neurosciences, Alfred Hospital, Melbourne, Australia
  • Van Cleef Roet Centre for Nervous Diseases, Monash University, Melbourne, Australia
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2011-02-23 | DOI: https://doi.org/10.1515/CCLM.2011.077


With the aging population in the Western hemisphere, neurodegenerative parkinsonism and dementia will become two of the great public health challenges of this century. A major pillar in the effort to treat these conditions will be the shift from symptomatic treatment to disease modifying therapy. This step will absolutely require cheap and reliable biomarkers; patients will need to be diagnosed before irreversible change has occurred. α-Synuclein (αS) is a recent candidate biomarker for Lewy body neurodegeneration. It is a 140 amino acid protein that forms the pathological substrate in idiopathic Parkinson's disease (IPD), dementia with Lewy bodies (DLB), as well as multiple system atrophy (MSA), a group of disorders collectively known as the synucleopathies. Biomarker research has investigated αS in blood, skin and cerebrospinal fluid (CSF). Plasma assays have demonstrated inconsistent results but CSF assays show a higher degree of uniformity, mostly demonstrating lower levels of αS in patients with Lewy body disease compared to controls. These results are not yet accurate or reliable enough to use as screening tools or isolated diagnostic tests in established disease. It has become clear that factors other than neurodegeneration affect αS concentrations in these tissue samples, such as genetic and environmental influences. Future studies using standardized techniques and larger patient numbers are awaited to realise the full potential of αS as a more definitive diagnostic biomarker.

Keywords: α-synuclein; dementia with Lewy bodies; multiple system atrophy; Parkinson's disease; synucleopathy

About the article

Corresponding author: A/Prof. David R. Williams, Van Cleef Roet Centre for Nervous Diseases, Monash University, Commercial Road, Melbourne 3004, Australia Phone: +61 90765231, Fax: +61 3 90762671

Received: 2010-09-03

Accepted: 2010-11-21

Published Online: 2011-02-23

Published in Print: 2011-03-01

Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2011.077.

Export Citation

©2011 by Walter de Gruyter Berlin New York. Copyright Clearance Center

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Niklas K. U. Koehler, Elke Stransky, Mirjam Meyer, Susanne Gaertner, Mona Shing, Martina Schnaidt, Maria S. Celej, Thomas M. Jovin, Thomas Leyhe, Christoph Laske, Anil Batra, Gerhard Buchkremer, Andreas J. Fallgatter, Dorothee Wernet, Elke Richartz-Salzburger, and Patrick Lewis
PLOS ONE, 2015, Volume 10, Number 4, Page e0123444
K. David Kennedy, S. A. AnithaChristy, LaKisha K. Buie, Teresa Borrás, and Reiner Albert Veitia
PLoS ONE, 2012, Volume 7, Number 5, Page e36301
Franc Llorens, Matthias Schmitz, Daniela Varges, Niels Kruse, Nadine Gotzmann, Karin Gmitterová, Brit Mollenhauer, and Inga Zerr
Journal of Neurology, 2016, Volume 263, Number 11, Page 2271
A. K. Emelyanov, P. A. Andoskin, I. V. Miliukhina, A. A. Timofeeva, A. F. Yakimovskii, K. A. Senkevich, M. A. Nikolaev, and S. N. Pchelina
Cell and Tissue Biology, 2016, Volume 10, Number 4, Page 277
Brian Spencer, Changyoun Kim, Tania Gonzalez, Alejandro Bisquertt, Christina Patrick, Edward Rockenstein, Anthony Adame, Seung-Jae Lee, Paula Desplats, and Eliezer Masliah
Human Molecular Genetics, 2016, Volume 25, Number 6, Page 1100
Brian Spencer, Elvira Valera, Edward Rockenstein, Margarita Trejo-Morales, Anthony Adame, and Eliezer Masliah
Molecular Neurodegeneration, 2015, Volume 10, Number 1
Joeri Verasdonck, Luc Bousset, Julia Gath, Ronald Melki, Anja Böckmann, and Beat H. Meier
Biomolecular NMR Assignments, 2016, Volume 10, Number 1, Page 5
Xuemei Wang, Shun Yu, Fangfei Li, and Tao Feng
Neuroscience Letters, 2015, Volume 599, Page 115
Hu Rong, Luo Jin, Wang Wei, Xuefeng Wang, and Zhiqin Xi
Seizure, 2015, Volume 27, Page 6
Diane B. Miller and James P. O’Callaghan
Metabolism, 2015, Volume 64, Number 3, Page S40
Brian Spencer, Sharareh Emadi, Paula Desplats, Simona Eleuteri, Sarah Michael, Kori Kosberg, Jay Shen, Edward Rockenstein, Christina Patrick, Anthony Adame, Tania Gonzalez, Michael Sierks, and Eliezer Masliah
Molecular Therapy, 2014, Volume 22, Number 10, Page 1753
Sangwook Lee, Edina Silajdžić, Hon Yang, Maria Björkqvist, Soyon Kim, Ok Chan Jeong, Oskar Hansson, and Thomas Laurell
Microchimica Acta, 2014, Volume 181, Number 9-10, Page 1143
Veronica Lindström, Elisabet Ihse, Therese Fagerqvist, Joakim Bergström, Eva Nordström, Christer Möller, Lars Lannfelt, and Martin Ingelsson
Immunotherapy, 2014, Volume 6, Number 2, Page 141
Aaron B. Bowman, Gunnar F. Kwakye, Elena Herrero Hernández, and Michael Aschner
Perspectives in Medicine, 2014, Volume 2, Number 1-4, Page 91
Hui-Hsing Hung, Wei-Pang Huang, and Chien-Yuan Pan
Cell Biology and Toxicology, 2013, Volume 29, Number 6, Page 415
Kim Henriksen, Sid E. O’Bryant, Harald Hampel, John Q. Trojanowski, Thomas J. Montine, Andreas Jeromin, Kaj Blennow, Anders Lönneborg, Tony Wyss-Coray, Holly Soares, Chantal Bazenet, Magnus Sjögren, William Hu, Simon Lovestone, Morten A. Karsdal, and Michael W. Weiner
Alzheimer's & Dementia, 2014, Volume 10, Number 1, Page 115
Sibylle E. Eisbach and Tiago F. Outeiro
Journal of Molecular Medicine, 2013, Volume 91, Number 6, Page 693
Junjun Zhou, Yi Sun, Xin Zhao, Zheng Deng, and Xiaoping Pu
Brain Research, 2013, Volume 1508, Page 53
Magdalena Nutu, Philippe Bourgeois, Henrik Zetterberg, Erik Portelius, Ulf Andreasson, Stéphane Parent, Francesco Lipari, Sara Hall, Radu Constantinescu, Oskar Hansson, and Kaj Blennow
NeuroMolecular Medicine, 2013, Volume 15, Number 1, Page 169
Ji-Hyeon Ahn, Jung-Hoon Choi, Joon-Ha Park, Bing-Chun Yan, In-Hye Kim, Jae-Chul Lee, Dae-Hwan Lee, Jin-Sang Kim, Hyung-Cheul Shin, and Moo-Ho Won
Laboratory Animal Research, 2012, Volume 28, Number 3, Page 165
Ji Hyeon Ahn, Joon Ha Park, Bing Chun Yan, Jae-Chul Lee, Jung Hoon Choi, Choong Hyun Lee, Ki-Yeon Yoo, In Koo Hwang, Jin Sang Kim, Hyung-Cheul Shin, and Moo-Ho Won
Cellular and Molecular Neurobiology, 2013, Volume 33, Number 1, Page 75
J.-C. Corvol
Revue Neurologique, 2012, Volume 168, Number 11, Page 796
Y. Wang, M. G. Sørensen, Q. Zheng, C. Zhang, M. A. Karsdal, and K. Henriksen
International Journal of Alzheimer's Disease, 2012, Volume 2012, Page 1
Altaf S Darvesh, Richard T Carroll, Anupam Bishayee, Nicholas A Novotny, Werner J Geldenhuys, and Cornelis J Van der Schyf
Expert Opinion on Investigational Drugs, 2012, Volume 21, Number 8, Page 1123
Kurt Jellinger
Translational Neuroscience, 2012, Volume 3, Number 2
Julia Gath, Birgit Habenstein, Luc Bousset, Ronald Melki, Beat H. Meier, and Anja Böckmann
Biomolecular NMR Assignments, 2012, Volume 6, Number 1, Page 51
Claire Henchcliffe, Richard Dodel, and M. Flint Beal
Progress in Neurobiology, 2011, Volume 95, Number 4, Page 601
Aaron B. Bowman, Gunnar F. Kwakye, Elena Herrero Hernández, and Michael Aschner
Journal of Trace Elements in Medicine and Biology, 2011, Volume 25, Number 4, Page 191
Jonathan J. Sager and Gonzalo E. Torres
Biochemistry, 2011, Volume 50, Number 34, Page 7295

Comments (0)

Please log in or register to comment.
Log in