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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

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1437-4331
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Volume 49, Issue 3 (Mar 2011)

Issues

α-Synuclein in Parkinson disease and other neurodegenerative disorders

Michael Eller / David R. Williams
  • Department of Neurosciences, Alfred Hospital, Melbourne, Australia
  • Van Cleef Roet Centre for Nervous Diseases, Monash University, Melbourne, Australia
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Published Online: 2011-02-23 | DOI: https://doi.org/10.1515/CCLM.2011.077

Abstract

With the aging population in the Western hemisphere, neurodegenerative parkinsonism and dementia will become two of the great public health challenges of this century. A major pillar in the effort to treat these conditions will be the shift from symptomatic treatment to disease modifying therapy. This step will absolutely require cheap and reliable biomarkers; patients will need to be diagnosed before irreversible change has occurred. α-Synuclein (αS) is a recent candidate biomarker for Lewy body neurodegeneration. It is a 140 amino acid protein that forms the pathological substrate in idiopathic Parkinson's disease (IPD), dementia with Lewy bodies (DLB), as well as multiple system atrophy (MSA), a group of disorders collectively known as the synucleopathies. Biomarker research has investigated αS in blood, skin and cerebrospinal fluid (CSF). Plasma assays have demonstrated inconsistent results but CSF assays show a higher degree of uniformity, mostly demonstrating lower levels of αS in patients with Lewy body disease compared to controls. These results are not yet accurate or reliable enough to use as screening tools or isolated diagnostic tests in established disease. It has become clear that factors other than neurodegeneration affect αS concentrations in these tissue samples, such as genetic and environmental influences. Future studies using standardized techniques and larger patient numbers are awaited to realise the full potential of αS as a more definitive diagnostic biomarker.

Keywords: α-synuclein; dementia with Lewy bodies; multiple system atrophy; Parkinson's disease; synucleopathy

About the article

Corresponding author: A/Prof. David R. Williams, Van Cleef Roet Centre for Nervous Diseases, Monash University, Commercial Road, Melbourne 3004, Australia Phone: +61 90765231, Fax: +61 3 90762671


Received: 2010-09-03

Accepted: 2010-11-21

Published Online: 2011-02-23

Published in Print: 2011-03-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2011.077.

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©2011 by Walter de Gruyter Berlin New York. Copyright Clearance Center

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