Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 49, Issue 3 (Mar 2011)

Issues

Advanced glycation endproducts as gerontotoxins and biomarkers for carbonyl-based degenerative processes in Alzheimer's disease

Anton Rahmadi
  • Department of Pharmacology, School of Medicine, University of Western Sydney, Campbelltown, Australia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Nicole Steiner
  • Department of Pharmacology, School of Medicine, University of Western Sydney, Campbelltown, Australia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Gerald Münch
Published Online: 2011-01-31 | DOI: https://doi.org/10.1515/CCLM.2011.079

Abstract

Alzheimer's disease (AD) is the most common dementia disorder of later life. Although there might be various different triggering events in the early stages of the disease, they appear to converge on a few characteristic final pathways in the late stages, characterized by inflammation and neurodegeneration. Here, we review the hypothesis that advanced glycation end products (AGEs), which reflect carbonyl stress, an imbalance between the production of reactive carbonyl compounds and their detoxification, can serve as biomarkers for the progression of disorder. AGE modification may explain many of the neuropathological and biochemical features of AD, such as extensive protein cross-linking shown as amyloid plaques and neurofibrillary tangles, inflammation, oxidative stress and neuronal cell death. Although accumulation of AGEs is a normal feature of aging, it appears to be significantly accelerated in AD. We suggest that higher AGE concentrations in brain tissue and in cerebrospinal fluid might be able to distinguish between normal aging and AD.

Keywords: advanced glycation end products; Alzheimer's disease; carbonyl stress; gerontotoxins; methylglyoxal

About the article

Corresponding author: Associate Professor Gerald Münch, Department of Pharmacology, School of Medicine, University of Western Sydney, Locked Bag 1797, Penrith South DC, NSW 1797, Australia Phone: +61 2 9852 4718, Fax: +61 2 9852 4730


Received: 2010-08-30

Accepted: 2010-10-25

Published Online: 2011-01-31

Published in Print: 2011-03-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2011.079.

Export Citation

©2011 by Walter de Gruyter Berlin New York. Copyright Clearance Center

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
V. I. Muronetz, A. K. Melnikova, Z. N. Seferbekova, K. V. Barinova, and E. V. Schmalhausen
Biochemistry (Moscow), 2017, Volume 82, Number 8, Page 874
[2]
Hans Drenth, Sytse U. Zuidema, Wim P. Krijnen, Ivan Bautmans, Cees van der Schans, and Hans Hobbelen
Journal of the American Medical Directors Association, 2017, Volume 18, Number 7, Page 636.e7
[3]
Dorit Bennmann, Rüdiger Horstkorte, Britt Hofmann, Kathleen Jacobs, Alexander Navarrete-Santos, Andreas Simm, Kaya Bork, Vinayaga S. Gnanapragassam, and Alan Stitt
PLoS ONE, 2014, Volume 9, Number 11, Page e112115
[4]
Hans Drenth, Sytse Zuidema, Steven Bunt, Ivan Bautmans, Cees van der Schans, and Hans Hobbelen
European Review of Aging and Physical Activity, 2016, Volume 13, Number 1
[5]
Cristina Angeloni, Marco Malaguti, Benedetta Rizzo, Maria Cristina Barbalace, Daniele Fabbri, and Silvana Hrelia
Chemical Research in Toxicology, 2015, Volume 28, Number 6, Page 1234
[6]
Elisabetta Bigagli, Cristina Luceri, Tania Scartabelli, Piero Dolara, Fiorella Casamenti, Domenico E. Pellegrini-Giampietro, and Lisa Giovannelli
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2016, Volume 71, Number 1, Page 50
[7]
Suzanne M. de la Monte and Ming Tong
Biochemical Pharmacology, 2014, Volume 88, Number 4, Page 548
[8]
James D. Weinstein, Edgar R. Gonzalez, Richard D. Egleton, and David A. Hunt
The Consultant Pharmacist, 2013, Volume 28, Number 7, Page 443
[9]
Dhanushka Gunawardena, Kirubakaran Shanmugam, Mitchell Low, Louise Bennett, Suresh Govindaraghavan, Richard Head, Lezanne Ooi, and Gerald Münch
European Journal of Nutrition, 2014, Volume 53, Number 1, Page 335
[10]
Yukiko Nakajima, Yuji Inagaki, Yuka Hiroshima, Jun-ichi Kido, and Toshihiko Nagata
Journal of Endodontics, 2013, Volume 39, Number 7, Page 873
[11]
Waqar Ahmad
Molecular Neurobiology, 2013, Volume 47, Number 1, Page 399
[12]
Stig Bengmark
Pharmacological Research, 2013, Volume 69, Number 1, Page 87
[13]
Lezanne Ooi, Kuldip Sidhu, Anne Poljak, Greg Sutherland, Michael D. O’Connor, Perminder Sachdev, and Gerald Münch
Journal of Neural Transmission, 2013, Volume 120, Number 1, Page 103
[14]
Qing-Qing Yin, Chuan-Fang Dong, Si-Qin Dong, Xue-Li Dong, Yan Hong, Xun-Yao Hou, Ding-Zhen Luo, Jin-Jing Pei, and Xue-Ping Liu
Cellular and Molecular Neurobiology, 2012, Volume 32, Number 8, Page 1299
[15]
Dora Il'yasova, Peter Scarbrough, and Ivan Spasojevic
Clinica Chimica Acta, 2012, Volume 413, Number 19-20, Page 1446
[16]
Zhenlie Huang, Sahoko Ichihara, Shinji Oikawa, Jie Chang, Lingyi Zhang, Kaviarasan Subramanian, Sahabudeen Sheik Mohideen, and Gaku Ichihara
Toxicology and Applied Pharmacology, 2012, Volume 263, Number 1, Page 44
[17]
Jinlong Li, Danian Liu, Ling Sun, Yunting Lu, and Zhongling Zhang
Journal of the Neurological Sciences, 2012, Volume 317, Number 1-2, Page 1
[18]
Lorena Perrone, Oualid Sbai, Peter P. Nawroth, and Angelika Bierhaus
International Journal of Alzheimer's Disease, 2012, Volume 2012, Page 1

Comments (0)

Please log in or register to comment.
Log in