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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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CiteScore 2016: 2.21

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Volume 49, Issue 6


Low-density lipoprotein receptor-related protein 1: new functions for an old molecule

Massimo Franchini
  • Servizio di Immunoematologia e Medicina Trasfusionale, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero – Universitaria di Parma, Parma, Italy
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/ Martina Montagnana
Published Online: 2011-03-11 | DOI: https://doi.org/10.1515/CCLM.2011.154


The low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional cell surface receptor member of the low-density lipoprotein (LDL)-receptor family. As LRP1 plays an important role in endocytosis and regulation of signalling pathways, it is implicated in a number of physiologic processes, including the regulation of lipid metabolism, the proliferation of vascular smooth muscle cells and in neuro-development. More recently, LRP1 has been implicated in the catabolism of factor VIII and regulation of its plasma concentrations. The pathophysiology of the role of LRP1 in hemostasis will be summarized in this review.

Keywords: endocytosis; factor VIII (FVIII); lipoprotein receptor-related protein 1 (LRP1); thrombosis

About the article

Corresponding author: Massimo Franchini, MD, Director, Servizio di Immunoematologia e Medicina Trasfusionale, Azienda Ospedaliero – Universitaria di Parma, Via Gramsci, 14 – 43100 Parma, Italy Phone: +390521703194, Fax: +390521703197

Received: 2010-12-09

Accepted: 2010-12-29

Published Online: 2011-03-11

Published in Print: 2011-06-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 49, Issue 6, Pages 967–970, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2011.154.

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©2011 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

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