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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Volume 49, Issue 7

Issues

Current role of liquid chromatography coupled to mass spectrometry in clinical toxicology screening methods

Véronique Viette
  • Department of Genetic Medicine and Laboratory, Service of Laboratory Medicine, Toxicology Laboratory, Geneva University Hospital, Geneva, Switzerland
  • ADMed Laboratories, La Chaux-de-Fonds, Switzerland
  • Swiss Center of Applied Human Toxicology, University of Geneva, CMU, Geneva, Switzerland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Marc Fathi
  • Department of Genetic Medicine and Laboratory, Service of Laboratory Medicine, Toxicology Laboratory, Geneva University Hospital, Geneva, Switzerland
  • Swiss Center of Applied Human Toxicology, University of Geneva, CMU, Geneva, Switzerland
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Serge Rudaz
  • Swiss Center of Applied Human Toxicology, University of Geneva, CMU, Geneva, Switzerland
  • School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Denis Hochstrasser
  • Department of Genetic Medicine and Laboratory, Service of Laboratory Medicine, Toxicology Laboratory, Geneva University Hospital, Geneva, Switzerland
  • Swiss Center of Applied Human Toxicology, University of Geneva, CMU, Geneva, Switzerland
  • School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jean-Luc Veuthey
  • Swiss Center of Applied Human Toxicology, University of Geneva, CMU, Geneva, Switzerland
  • School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2011-06-27 | DOI: https://doi.org/10.1515/CCLM.2011.182

Abstract

Toxicological screening is the analysis of a biological specimen to detect and identify compounds in patients admitted to the hospital with acute intoxication of unknown origin. The screening of a wide range of toxicologically relevant compounds in biological samples is a serious challenge for clinical laboratories. The high selectivity and sensitivity of liquid chromatography coupled to mass spectrometry or tandem mass spectrometry technology provides an attractive alternative to the current methods. For these reasons, an increasing number of applications for multi-target screening or general screening of unknown compounds in biological matrices are being published. This paper is an overview of sample clean-up, chromatographic separation and mass spectrometry detection procedures which can be combined to obtain screening methods adapted to the constraints and needs of various laboratories, and none specifically in clinical toxicology. Currently the techniques are in the hands of specialists, principally in academic institutes. However, the evolution in technology should allow application of the techniques as a tool in toxicology laboratories and thus more widespread exploitation of their potential.

Keywords: clinical toxicology; identification; liquid chromatography/mass spectrometry (LC/MS); mass spectra; screening

About the article

Corresponding author: Marc Fathi, Department of Genetic Medicine and Laboratory, Service of Laboratory Medicine, Toxicology Laboratory, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland Phone: +41 22 37 27 385, Fax: +41 22 37 27 320


Received: 2010-09-27

Accepted: 2011-01-10

Published Online: 2011-06-27

Published in Print: 2011-07-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 49, Issue 7, Pages 1091–1103, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2011.182.

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