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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2017: 3.556

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Volume 49, Issue 7

Issues

Preanalytical quality improvement: from dream to reality

Giuseppe Lippi / Jeffrey J. Chance
  • Medical and Clinical Affairs, BD Diagnostics – Preanalytical Systems, Franklin Lakes, NJ, USA
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  • De Gruyter OnlineGoogle Scholar
/ Stephen Church / Paola Dazzi / Rossana Fontana / Davide Giavarina / Kjell Grankvist / Wim Huisman
  • Medical Centre Haaglanden, Department of Clinical Chemistry, The Hague, The Netherlands and Chair of the EFCC Working Group on Accreditation
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/ Timo Kouri / Vladimir Palicka
  • Institute of Clinical Biochemistry and Diagnostics, Charles' University of Prague, Prague, Czech Republic
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/ Mario Plebani
  • Department of Laboratory Medicine, Academic Hospital of Padova and Leonardo Foundation, Abano Terme General Hospital (PD), Padova, Italy
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/ Vincenzo Puro
  • Clinical Chemistry and Hematology Laboratory, Academic Hospital of Parma, Parma, Italy
  • Department of Epidemiology, National Institute for Infectious Diseases “L. Spallanzani”, Rome, Italy and Studio Italiano Rischio Occupazionale da HIV (SIROH)
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/ Gian Luca Salvagno
  • Clinical Chemistry and Hematology Laboratory, Academic Hospital of Parma, Parma, Italy
  • Clinical Biochemistry Laboratory, Department of Life and Reproduction Sciences, University Hospital of Verona, Verona, Italy
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/ Sverre Sandberg
  • Clinical Chemistry and Hematology Laboratory, Academic Hospital of Parma, Parma, Italy
  • Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway
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/ Ken Sikaris
  • Clinical Chemistry and Hematology Laboratory, Academic Hospital of Parma, Parma, Italy
  • Chemical Pathology, Sonic Health – Melbourne Pathology, Melbourne, Australia
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/ Ian Watson
  • Clinical Chemistry and Hematology Laboratory, Academic Hospital of Parma, Parma, Italy
  • Department of Clinical Biochemistry, University Hospital Aintree, Liverpool, UK
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/ Ana K. Stankovic
  • Medical and Clinical Affairs, BD Diagnostics – Preanalytical Systems, Franklin Lakes, NJ, USA
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/ Ana-Maria Simundic
  • Clinical Chemistry and Hematology Laboratory, Academic Hospital of Parma, Parma, Italy
  • Clinical Institute of Chemistry, University Hospital “Sestre Milosrdnice”, Zagreb, Croatia
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Published Online: 2011-04-26 | DOI: https://doi.org/10.1515/CCLM.2011.600

Abstract

Laboratory diagnostics (i.e., the total testing process) develops conventionally through a virtual loop, originally referred to as “the brain to brain cycle” by George Lundberg. Throughout this complex cycle, there is an inherent possibility that a mistake might occur. According to reliable data, preanalytical errors still account for nearly 60%–70% of all problems occurring in laboratory diagnostics, most of them attributable to mishandling procedures during collection, handling, preparing or storing the specimens. Although most of these would be “intercepted” before inappropriate reactions are taken, in nearly one fifth of the cases they can produce inappropriate investigations and unjustifiable increase in costs, while generating inappropriate clinical decisions and causing some unfortunate circumstances. Several steps have already been undertaken to increase awareness and establish a governance of this frequently overlooked aspect of the total testing process. Standardization and monitoring preanalytical variables is of foremost importance and is associated with the most efficient and well-organized laboratories, resulting in reduced operational costs and increased revenues. As such, this article is aimed at providing readers with significant updates on the total quality management of the preanalytical phase to endeavour further improvement for patient safety throughout this phase of the total testing process.

Keywords: errors; laboratory diagnostics; patient safety; preanalytical phase; quality

About the article

Corresponding author: Prof. Giuseppe Lippi, U.O. Diagnostica Ematochimica, Azienda Ospedaliero – Universitaria di Parma, Via Gramsci 14, 43126 Parma, Italy Phone: +39-0521-703050/703791


Received: 2011-01-28

Accepted: 2011-03-09

Published Online: 2011-04-26

Published in Print: 2011-07-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 49, Issue 7, Pages 1113–1126, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2011.600.

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