Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 49, Issue 7 (Jul 2011)

Issues

Preanalytical quality improvement: from dream to reality

Giuseppe Lippi / Jeffrey J. Chance
  • Medical and Clinical Affairs, BD Diagnostics – Preanalytical Systems, Franklin Lakes, NJ, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Stephen Church / Paola Dazzi / Rossana Fontana / Davide Giavarina / Kjell Grankvist / Wim Huisman
  • Medical Centre Haaglanden, Department of Clinical Chemistry, The Hague, The Netherlands and Chair of the EFCC Working Group on Accreditation
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Timo Kouri / Vladimir Palicka
  • Institute of Clinical Biochemistry and Diagnostics, Charles' University of Prague, Prague, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mario Plebani
  • Department of Laboratory Medicine, Academic Hospital of Padova and Leonardo Foundation, Abano Terme General Hospital (PD), Padova, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Vincenzo Puro
  • Clinical Chemistry and Hematology Laboratory, Academic Hospital of Parma, Parma, Italy
  • Department of Epidemiology, National Institute for Infectious Diseases “L. Spallanzani”, Rome, Italy and Studio Italiano Rischio Occupazionale da HIV (SIROH)
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Gian Luca Salvagno
  • Clinical Chemistry and Hematology Laboratory, Academic Hospital of Parma, Parma, Italy
  • Clinical Biochemistry Laboratory, Department of Life and Reproduction Sciences, University Hospital of Verona, Verona, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sverre Sandberg
  • Clinical Chemistry and Hematology Laboratory, Academic Hospital of Parma, Parma, Italy
  • Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ken Sikaris
  • Clinical Chemistry and Hematology Laboratory, Academic Hospital of Parma, Parma, Italy
  • Chemical Pathology, Sonic Health – Melbourne Pathology, Melbourne, Australia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ian Watson
  • Clinical Chemistry and Hematology Laboratory, Academic Hospital of Parma, Parma, Italy
  • Department of Clinical Biochemistry, University Hospital Aintree, Liverpool, UK
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ana K. Stankovic
  • Medical and Clinical Affairs, BD Diagnostics – Preanalytical Systems, Franklin Lakes, NJ, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ana-Maria Simundic
  • Clinical Chemistry and Hematology Laboratory, Academic Hospital of Parma, Parma, Italy
  • Clinical Institute of Chemistry, University Hospital “Sestre Milosrdnice”, Zagreb, Croatia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2011-04-26 | DOI: https://doi.org/10.1515/CCLM.2011.600

Abstract

Laboratory diagnostics (i.e., the total testing process) develops conventionally through a virtual loop, originally referred to as “the brain to brain cycle” by George Lundberg. Throughout this complex cycle, there is an inherent possibility that a mistake might occur. According to reliable data, preanalytical errors still account for nearly 60%–70% of all problems occurring in laboratory diagnostics, most of them attributable to mishandling procedures during collection, handling, preparing or storing the specimens. Although most of these would be “intercepted” before inappropriate reactions are taken, in nearly one fifth of the cases they can produce inappropriate investigations and unjustifiable increase in costs, while generating inappropriate clinical decisions and causing some unfortunate circumstances. Several steps have already been undertaken to increase awareness and establish a governance of this frequently overlooked aspect of the total testing process. Standardization and monitoring preanalytical variables is of foremost importance and is associated with the most efficient and well-organized laboratories, resulting in reduced operational costs and increased revenues. As such, this article is aimed at providing readers with significant updates on the total quality management of the preanalytical phase to endeavour further improvement for patient safety throughout this phase of the total testing process.

Keywords: errors; laboratory diagnostics; patient safety; preanalytical phase; quality

About the article

Corresponding author: Prof. Giuseppe Lippi, U.O. Diagnostica Ematochimica, Azienda Ospedaliero – Universitaria di Parma, Via Gramsci 14, 43126 Parma, Italy Phone: +39-0521-703050/703791


Received: 2011-01-28

Accepted: 2011-03-09

Published Online: 2011-04-26

Published in Print: 2011-07-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2011.600.

Export Citation

©2011 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[2]
Fabio Manoni, Gianluca Gessoni, Maria Grazia Alessio, Alberta Caleffi, Graziella Saccani, Maria Grazia Silvestri, Donatella Poz, Mauro Ercolin, Agostino Tinello, Sara Valverde, Cosimo Ottomano, and Giuseppe Lippi
Clinical Chemistry and Laboratory Medicine, 2012, Volume 50, Number 4
[3]
Giuseppe Lippi and Ana-Maria Simundic
Clinical Chemistry and Laboratory Medicine (CCLM), 2017, Volume 0, Number 0
[4]
Veronica Restelli, Annemarie Taylor, Douglas Cochrane, and Michael A. Noble
Diagnosis, 2017, Volume 0, Number 0
[5]
Felipe Vogt Cureau, Katia Vergetti Bloch, Aline Henz, Camila W. Schaan, Carlos Henrique Klein, Cecília Lacroix de Oliveira, Denise Tavares Giannini, Elisa Brosina de Leon, Gabriela de Azevedo Abreu, Gabriela Heiden Telo, Glauber Monteiro Dias, Kênia Mara Baiocchi de Carvalho, Laura Augusta Barufaldi, Maria Cristina Caetano Kuschnir, Moyses Szklo, Renan Montenegro Jr., Thiago Luiz Nogueira da Silva, Ulf Ekelund, and Beatriz D. Schaan
Cadernos de Saúde Pública, 2017, Volume 33, Number 4
[6]
Ahmad Haeri Mazanderani, Faith Moyo, Gayle G. Sherman, and Etsuro Ito
PLOS ONE, 2017, Volume 12, Number 5, Page e0177173
[7]
Martina Zaninotto, Adriano Tasinato, Gianni Vecchiato, Angelo Legnaro, Alessio Pinato, and Mario Plebani
Clinical Biochemistry, 2017, Volume 50, Number 10-11, Page 574
[9]
Giovanni Lombardi, Mosè Barbaro, Massimo Locatelli, and Giuseppe Banfi
Endocrine, 2017, Volume 56, Number 3, Page 460
[10]
Karin Nilsson, Christine Brulin, Kjell Grankvist, and Christina Juthberg
Nurse Education in Practice, 2017, Volume 23, Page 92
[11]
Giuseppe Lippi and Mario Plebani
Journal of Laboratory Automation, 2013, Volume 18, Number 2, Page 184
[12]
Giuseppe Lippi, Luigi Ippolito, and Emmanuel J. Favaloro
Journal of Laboratory Automation, 2013, Volume 18, Number 5, Page 382
[13]
Saba Sheikhbahaei, Roya Sherkat, Dirk Roos, Majid Yaran, Somayeh Najafi, and Alireza Emami
Allergy, Asthma & Clinical Immunology, 2016, Volume 12, Number 1
[14]
Giovanni Lombardi, Silvia Perego, Veronica Sansoni, and Giuseppe Banfi
Clinical Biochemistry, 2016, Volume 49, Number 18, Page 1331
[15]
D. M. Adcock, J. Mammen, S. C. Nair, and S. A. de Lima Montalvão
Haemophilia, 2016, Volume 22, Page 84
[16]
Feyisayo Jegede, Henry A. Mbah, Ado Dakata, Dalhatu H. Gwarzo, Surajudeen A. Abdulrahman, and Aisha Kuliya-Gwarzo
African Journal of Laboratory Medicine, 2016, Volume 5, Number 1
[17]
Nora Nikolac, Ivana Celap, Petra Filipi, Marina Hemar, Marija Kocijancic, Marijana Miler, Ana-Maria Simundic, Vesna Supak Smolcic, and Alen Vrtaric
Clinical Chemistry and Laboratory Medicine (CCLM), 2016, Volume 54, Number 3
[18]
Emmanuel J. Favaloro, Dorothy M. (Adcock) Funk, and Giuseppe Lippi
Laboratory Medicine, 2012, Volume 43, Number 2, Page 1.2
[19]
Daniela Stefania Grecu, Daliborca Cristina Vlad, and Victor Dumitrascu
Laboratory Medicine, 2014, Volume 45, Number 1, Page 74
[20]
Mario Plebani
Clinical Chemistry and Laboratory Medicine, 2013, Volume 51, Number 1
[21]
Karin Nilsson, Christina Juthberg, Johan Söderberg, Karin Bölenius, Kjell Grankvist, Christine Brulin, and Marie Lindkvist
BMC Health Services Research, 2015, Volume 15, Number 1
[22]
N. Barba-Meseguer, X. Martínez-Ollé, A. Alsius-Serra, M.L. López-Yeste, and I. Caballé-Martín
Revista de Calidad Asistencial, 2015, Volume 30, Number 6, Page 273
[23]
M.A. Cuadrado-Cenzual, M. García Briñón, Y. de Gracia Hills, M. González Estecha, L. Collado Yurrita, J.A. de Pedro Moro, C. Fernández Pérez, and M. Arroyo Fernández
Revista de Calidad Asistencial, 2015, Volume 30, Number 6, Page 310
[24]
Johan Malm, Henrik Lindberg, David Erlinge, Roger Appelqvist, Maria Yakovleva, Charlotte Welinder, Erik Steinfelder, Thomas E Fehniger, and György Marko-Varga
Clinical and Translational Medicine, 2015, Volume 4, Number 1
[25]
Miguel Cantero, Maximino Redondo, Eva Martín, Gonzalo Callejón, and María Luisa Hortas
Clinical Chemistry and Laboratory Medicine (CCLM), 2015, Volume 53, Number 2
[26]
Yuanyuan Jiang, Hongmin Jiang, Siyi Ding, and Qin Liu
Clinica Chimica Acta, 2015, Volume 448, Page 80
[27]
Satyavati V. Rana
Indian Journal of Clinical Biochemistry, 2012, Volume 27, Number 4, Page 319
[28]
Marija Culjak, Nora Nikolac, and Ana-Maria Simundic
Clinica Chimica Acta, 2015, Volume 446, Page 261
[29]
Verena Gounden, David B. Sacks, and Zhen Zhao
Clinica Chimica Acta, 2015, Volume 440, Page 3
[30]
Henry A. Mbah
African Journal of Laboratory Medicine, 2014, Volume 3, Number 1
[31]
C. Pérez de Ciriza, A. Lawrie, and N. Varo
Clinical Biochemistry, 2014, Volume 47, Number 13-14, Page 1279
[32]
L. Parés-Pollán, A. Gonzalez-Quintana, J. Docampo-Cordeiro, C. Vargas-Gallego, G. García-Álvarez, V. Ramos-Rodríguez, and M.P. Diaz Rubio-García
Revista de Calidad Asistencial, 2014, Volume 29, Number 4, Page 197
[33]
M. Plebani, L. Sciacovelli, A. Aita, A. Padoan, and M.L. Chiozza
Clinica Chimica Acta, 2014, Volume 432, Page 44
[34]
Jillian R Tate, Roger Johnson, Julian Barth, and Mauro Panteghini
Clinica Chimica Acta, 2014, Volume 432, Page 4
[35]
Eugène H. J. M. Jansen, Piet K. Beekhof, Johannes W. J. M. Cremers, Dale Viezeliene, Vladimira Muzakova, and Jiri Skalicky
ISRN Biomarkers, 2013, Volume 2013, Page 1
[36]
Maximilian Bielohuby, Sarah Popp, and Martin Bidlingmaier
Growth Hormone & IGF Research, 2013, Volume 23, Number 5, Page 141
[37]
Martina Montagnana, Renata Paleari, Elisa Danese, Gian Luca Salvagno, Giuseppe Lippi, Gian Cesare Guidi, and Andrea Mosca
Clinica Chimica Acta, 2013, Volume 423, Page 1
[38]
Giuseppe Lippi, Paola Avanzini, and Gianfranco Cervellin
Clinical Biochemistry, 2013, Volume 46, Number 7-8, Page 561
[39]
R. LOEFFEN, M.-C. F. KLEINEGRIS, S. T. B. G. LOUBELE, P. H. M. PLUIJMEN, D. FENS, R. van OERLE, H. ten CATE, and H. M. H. SPRONK
Journal of Thrombosis and Haemostasis, 2012, Volume 10, Number 12, Page 2544
[40]
Giuseppe Lippi and Massimo Franchini
Transfusion and Apheresis Science, 2013, Volume 49, Number 2, Page 181
[41]
Marit Sverresdotter Sylte, Tore Wentzel-Larsen, and Bjørn J. Bolann
Clinica Chimica Acta, 2013, Volume 415, Page 196
[42]
G. Lippi, F. Pavesi, C. Cattabiani, P. Avanzini, and S. Pipitone
International Journal of Laboratory Hematology, 2013, Volume 35, Number 2, Page 225
[43]
Maximilian Bielohuby, Sarah Popp, and Martin Bidlingmaier
Molecular Metabolism, 2012, Volume 1, Number 1-2, Page 47
[44]
Nada Majkić-Singh and Zorica Šumarac
Journal of Medical Biochemistry, 2012, Volume 31, Number 3
[45]
Jim Vaught and Nicole C. Lockhart
Clinica Chimica Acta, 2012, Volume 413, Number 19-20, Page 1569
[46]
M. Zaninotto, A. Tasinato, A. Padoan, G. Vecchiato, A. Pinato, L. Sciacovelli, and M. Plebani
Clinical Biochemistry, 2012, Volume 45, Number 9, Page 688
[47]
G. LIPPI, R. MUSA, P. AVANZINI, R. ALOE, S. PIPITONE, and F. SANDEI
International Journal of Laboratory Hematology, 2012, Volume 34, Number 2, Page 179
[48]
Laura Sciacovelli, Oswald Sonntag, Andrea Padoan, Carlo Federico Zambon, Paolo Carraro, and Mario Plebani
Clinical Chemistry and Laboratory Medicine, 2012, Volume 50, Number 3
[49]
Weihua Tang, Zhiyuan Hu, Hind Muallem, and Margaret L. Gulley
The Journal of Molecular Diagnostics, 2012, Volume 14, Number 1, Page 1
[50]
Dominika Szoke, Federica Braga, Cristina Valente, and Mauro Panteghini
Clinica Chimica Acta, 2012, Volume 413, Number 1-2, Page 339
[51]
Giuseppe Lippi, Oswald Sonntag, and Mario Plebani
Clinical Chemistry and Laboratory Medicine (CCLM), 2011, Volume 49, Number 12
[52]
Robert C. Hawkins
Clinical Chemistry and Laboratory Medicine (CCLM), 2011, Volume 49, Number 12

Comments (0)

Please log in or register to comment.
Log in