Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 49, Issue 8 (Aug 2011)

Issues

Dual activity of serum lipoprotein-associated phospholipase A2 yielding positive and inverse associations with cardiometabolic risk

Altan Onat
  • Turkish Society of Cardiology, Istanbul, Turkey
  • Department of Cardiology, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Gülay Hergenç / Günay Can
  • Department of Public Health, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Murat Uğur / Filiz Nartop
Published Online: 2011-07-14 | DOI: https://doi.org/10.1515/CCLM.2011.110

Abstract

Background: The clinical relevance of serum lipoprotein-associated phospholipase A2 (Lp-PLA2) in populations prone to cardiometabolic risk needs exploration. We determined major covariates of Lp-PLA2 mass, and its associations with cardiometabolic disorders.

Methods: In 736 Turkish adults, serum total Lp-PLA2 mass was determined by immunoassay. Its association with cardiometabolic risk was assessed in three categories. In a second sample of 98 subjects, enzyme protein in high-density lipoprotein (HDL) was also assayed after precipitation.

Results: Significant inverse correlation existed with high triglyceride/low HDL cholesterol dyslipidemia, waist girth, apolipoprotein C-III, homeostatic model assessment, and linear inverse associations in women with lipoprotein (a) and fibrinogen, suggesting that Lp-PLA2 mass reflected insulin sensitivity and that HDL bound enzyme mass dominated the associations. Among men, positive linear association with total cholesterol suggested additional association with low-density lipoprotein (LDL)-bound enzyme. High (>450 ng/mL) opposed to low (<210 ng/mL) circulating Lp-PLA2 mass was associated with prevalent and incident coronary heart disease (CHD) in men. One SD increment in Lp-PLA2 was associated with a 1.64-fold (95% CI 1.00; 2.70) likelihood of CHD, after adjustment for potential confounders. Furthermore, Lp-PLA2 categories were significantly, independently and inversely associated in men with diabetes only (OR 0.61) and in women with metabolic syndrome only (OR 0.68), for a 1-SD increment.

Conclusions: Serum total Lp-PLA2 mass may indicate either elevated or diminished cardiometabolic risk, specific for gender, depending on its partitioning in lipoprotein groups.

Keywords: atherogenic dyslipidemia; coronary heart disease; diabetes type-2; lipoprotein-associated phospholipase A2 mass

About the article

Corresponding author: Prof. Dr. Altan Onat, Nisbetiye cad. 59/24, Etiler 34335, İstanbul, Turkey Phone: +90 212 351 6217


Received: 2010-06-14

Accepted: 2010-11-07

Published Online: 2011-07-14

Published in Print: 2011-08-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2011.110.

Export Citation

©2011 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Julia Seyfarth, Thomas Reinehr, Annika Hoyer, Christina Reinauer, Christina Bächle, Beate Karges, Ertan Mayatepek, Michael Roden, Sabine E. Hofer, Susanna Wiegand, Joachim Woelfle, Wieland Kiess, Joachim Rosenbauer, Reinhard W. Holl, and Thomas Meissner
Journal of Inherited Metabolic Disease, 2017
[2]
Yanglu Zhao
Cardiovascular Endocrinology, 2017, Volume 6, Number 1, Page 17
[3]
Shibnath Kamila, Ashish Agrawal, Akbarunnisa Begum, and Sri Krishna Reddy
Current Medicine Research and Practice, 2017, Volume 7, Number 1, Page 2
[4]
Altan Onat, Tuğba Akbaş, and Hüsniye Yüksel
European Journal of Internal Medicine, 2015, Volume 26, Number 1, Page 72
[5]
Otto Mayer, Jitka Seidlerová, Jan Filipovský, Katarina Timoracká, Jan Bruthans, Jiří Vaněk, Lenka Černá, Peter Wohlfahrt, Cífková Renata, and Ladislav Trefil
European Journal of Internal Medicine, 2014, Volume 25, Number 6, Page 556
[6]
Altan Onat, H. Altuğ Çakmak, Günay Can, Murat Yüksel, Bayram Köroğlu, and Hüsniye Yüksel
Clinical Nutrition, 2014, Volume 33, Number 5, Page 815

Comments (0)

Please log in or register to comment.
Log in