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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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Dual activity of serum lipoprotein-associated phospholipase A2 yielding positive and inverse associations with cardiometabolic risk

Altan Onat
  • Turkish Society of Cardiology, Istanbul, Turkey
  • Department of Cardiology, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey
  • :
/ Gülay Hergenç
  • Department of Biology, Yildiz Technical University, Istanbul, Istanbul, Turkey
/ Günay Can
  • Department of Public Health, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey
/ Murat Uğur
  • Siyami Ersek Center for Cardiovascular Surgery, Istanbul, Turkey
/ Filiz Nartop
  • Biochemistry Laboratory, Göztepe Educational Hospital, Istanbul, Turkey
Published Online: 2011-07-14 | DOI: https://doi.org/10.1515/CCLM.2011.110

Abstract

Background: The clinical relevance of serum lipoprotein-associated phospholipase A2 (Lp-PLA2) in populations prone to cardiometabolic risk needs exploration. We determined major covariates of Lp-PLA2 mass, and its associations with cardiometabolic disorders.

Methods: In 736 Turkish adults, serum total Lp-PLA2 mass was determined by immunoassay. Its association with cardiometabolic risk was assessed in three categories. In a second sample of 98 subjects, enzyme protein in high-density lipoprotein (HDL) was also assayed after precipitation.

Results: Significant inverse correlation existed with high triglyceride/low HDL cholesterol dyslipidemia, waist girth, apolipoprotein C-III, homeostatic model assessment, and linear inverse associations in women with lipoprotein (a) and fibrinogen, suggesting that Lp-PLA2 mass reflected insulin sensitivity and that HDL bound enzyme mass dominated the associations. Among men, positive linear association with total cholesterol suggested additional association with low-density lipoprotein (LDL)-bound enzyme. High (>450 ng/mL) opposed to low (<210 ng/mL) circulating Lp-PLA2 mass was associated with prevalent and incident coronary heart disease (CHD) in men. One SD increment in Lp-PLA2 was associated with a 1.64-fold (95% CI 1.00; 2.70) likelihood of CHD, after adjustment for potential confounders. Furthermore, Lp-PLA2 categories were significantly, independently and inversely associated in men with diabetes only (OR 0.61) and in women with metabolic syndrome only (OR 0.68), for a 1-SD increment.

Conclusions: Serum total Lp-PLA2 mass may indicate either elevated or diminished cardiometabolic risk, specific for gender, depending on its partitioning in lipoprotein groups.

Keywords: atherogenic dyslipidemia; coronary heart disease; diabetes type-2; lipoprotein-associated phospholipase A2 mass

Corresponding author: Prof. Dr. Altan Onat, Nisbetiye cad. 59/24, Etiler 34335, İstanbul, Turkey Phone: +90 212 351 6217


Received: 2010-06-14

Accepted: 2010-11-07

Published Online: 2011-07-14

Published in Print: 2011-08-01


Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 49, Issue 8, Pages 1349–1357, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2011.110, July 2011

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[2]
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