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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

Online
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1437-4331
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Volume 49, Issue 9 (Sep 2011)

Issues

Prognostic value of cystatin C in acute coronary syndromes: enhancer of atherosclerosis and promising therapeutic target

Simona Ferraro
  • SCDO, Cardiologia 2, Ospedale Maggiore, Novara, Italy
  • Sezione Statistica Medica e Biometria, Dipartimento di Medicina del Lavoro, Università degli Studi, Milan, Italy
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Giuseppe Marano
  • Sezione Statistica Medica e Biometria, Dipartimento di Medicina del Lavoro, Università degli Studi, Milan, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Elia M. Biganzoli
  • Sezione Statistica Medica e Biometria, Dipartimento di Medicina del Lavoro, Università degli Studi, Milan, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Patrizia Boracchi
  • Sezione Statistica Medica e Biometria, Dipartimento di Medicina del Lavoro, Università degli Studi, Milan, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Angelo S. Bongo
Published Online: 2011-05-27 | DOI: https://doi.org/10.1515/CCLM.2011.607

Abstract

Background: Cystatin C (CC) has been proposed to play a role in atherosclerosis. We aimed to review the prognostic value of CC serum/plasma levels in patients with acute coronary syndromes (ACS).

Methods: Fifteen observational longitudinal studies were selected by Medline.

Results: Increased CC over threshold values ranging from 0.93 to 1.3 mg/L were prognostic for death (hazard ratio; HR: 2.04–3.6) and for the occurrence of any fatal and non-fatal cardiovascular events (HR: 1.7–9.6) for patients with either ACS only or coronary heart disease and prevalent ACS. Only one study showed an increased risk for future myocardial infarction (MI) in patients with marker levels higher than 1.0 mg/L. Three studies reported the risk associated with a change of one unit of CC for long-term death (HR ranging from 1.9 to 6.3) and for the composite end point of 1 year MI and death (HR 2.15). Some studies showed the additional prognostic value contributed from CC measurements to other markers and to conventional risk scores.

Conclusion: Despite low to moderate evidence, there is a general agreement on the significant prognostic value of CC in ACS that might encourage further research focused on risk assessment for patients with MI.

Keywords: acute coronary syndromes; atherosclerosis; inflammatory biomarkers; prognosis; risk factor

About the article

Corresponding author: Simona Ferraro, SCDO Cardiologia 2, Ospedale Maggiore, Corso Mazzini 18, Novara 28100, Italy Phone: +393471598351, Fax: +390250320866


Received: 2011-02-15

Accepted: 2011-04-15

Published Online: 2011-05-27

Published in Print: 2011-09-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2011.607.

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©2011 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

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