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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Volume 50, Issue 1 (Jan 2012)


Ultra-sensitive troponin I levels to exclude acute myocardial infarction from myocardial injury

Simona Ferraro
  • SCDO Cardiologia, Ospedale Maggiore, Novara, Italy
  • Istituto Statistica Medica e Biometria, Università degli Studi, Milan, Italy
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  • Other articles by this author:
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/ Patrizia Boracchi / Matteo Santagostino / Giuseppe Marano / Chiara Vendramin / Lidia Rossi / Elia M. Biganzoli / Marcello Galvani / Aldo Clerico / Angelo S. Bongo
Published Online: 2011-10-06 | DOI: https://doi.org/10.1515/cclm.2011.746


Background: Third generation troponin assays should aid in the rule-out of acute myocardial infarction (AMI). The study aim was to assess the capability of admission measurement of ultra-sensitive troponin I (TnI-Ultra) to exclude AMI from other myocardial injury.

Methods: The first TnI-Ultra sample from 856 patients at presentation to the Emergency Department and subsequent admission to the Cardiac Care Unit were considered in this case series. Myoglobin was simultaneously detected in 684 patients.

Results: The sensitivity of the first single TnI-Ultra level was 82.5% in overall AMI, and similar in ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI), admitted, respectively at 3 and 8 h from symptoms. The diagnostic capability of a first single TnI-Ultra level was poor for both STEMI and NSTEMI to discriminate and rule-out overall AMI from myocardial injury, with an area under the receiver-operating curve of 0.65 and a negative likelihood ratio of 0.55. Adopting an optimal test threshold or adding myoglobin detection did not improve TnI-Ultra performances.

Conclusions: The capability of a first single TnI-Ultra level to exclude AMI from other myocardial injury in early and late presenters is poor. Addition of myoglobin assay offered no further improvement and was not considered useful.

Keywords: acute myocardial infarction; biomarkers; diagnosis; sensitivity; troponin

About the article

Corresponding author: Dr. Simona Ferraro, Ospedale Maggiore della Carità, SCDO, Cardiologia 2, C.so Mazzini 18, 28100 Novara, Italy Phone: +39/3471598351, Fax: +39/03213733516

Received: 2011-03-09

Accepted: 2011-09-17

Published Online: 2011-10-06

Published in Print: 2012-01-01

Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm.2011.746.

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©2011 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

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