Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year

IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

SCImago Journal Rank (SJR) 2017: 1.114
Source Normalized Impact per Paper (SNIP) 2017: 1.188

See all formats and pricing
More options …
Volume 50, Issue 11


Exhaled breath analysis for early cancer detection: principle and progress in direct mass spectrometry techniques

Koffi Badjagbo
Published Online: 2012-05-30 | DOI: https://doi.org/10.1515/cclm-2012-0208


Volatile biomarker analysis in exhaled breath is becoming one of the desirable strategies for cancer detection because it may offer a relatively inexpensive, rapid, and non-invasive screening method for early diagnosis. Breath analysis has attracted a considerable amount of scientific and clinical interest over the past decade. However, breath is not yet used for routine medical diagnostic purposes. Challenges faced in the development of breath analysis for cancer diagnosis include developing techniques that can measure biomarkers in exhaled breath at ultratrace levels, providing definitive evidence for their presence and for the relationship between the proposed biomarker and the underlying condition. Various analytical methods are used for the detection of breath biomarkers. Gas chromatography-based methods which involve sample collection, analyte preconcentration, desorption, and separation steps are the most popular. However, direct-sampling mass spectrometry techniques have been proven more reliable for air analysis without prior sample pretreatment or chromatographic separation. This review focuses on the most commonly used direct mass spectrometry methods for the direct online analysis of endogenous cancer biomarkers in exhaled breath, with particular attention to principle of detection, method performance, advantages, shortcomings, recent advances, and applications within health-related studies for cancer biomarkers research. The principle behind the science of breath analysis for cancer diagnosis is also discussed.

Keywords: cancer; direct-sampling mass spectrometry; exhaled breath; proton transfer reaction mass spectrometry; selected ion flow tube mass spectrometry; volatile biomarker

About the article

Koffi Badjagbo

Dr. Koffi Badjagbo graduated from the School of Applied Science, Université de Lomé in Togo. He undertook MSc studies and obtained a PhD in Analytical Chemistry at the Université de Montréal, Canada. Before becoming a Lecturer of Analytical Chemistry and Environmental Chemistry in the Université de Montréal in 2010 and then an Assistant Professor in 2012, he worked as an Associate Researcher for Phytronix Technologies and as a Researcher for the Laboratory of Environmental Chemistry, QC, Canada, for over 5 years. His research includes applications of direct mass spectrometry in bioanalytical chemistry and in atmospheric chemistry, development of direct real-time monitoring methods for volatile biomarkers in exhaled breath and for volatile organic compounds in ambient air.

Corresponding author: Koffi Badjagbo, Department of Chemistry, Université de Montréal, CP 6128 Centre-ville, Montréal, H3C 3J7, QC, Canada Phone: +1 514 343-6111 ext. 3921

Received: 2012-03-30

Accepted: 2012-05-01

Published Online: 2012-05-30

Published in Print: 2012-11-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 50, Issue 11, Pages 1893–1902, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2012-0208.

Export Citation

©2012 by Walter de Gruyter Berlin Boston.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Kenta Iitani, Po-Jen Chien, Takuma Suzuki, Koji Toma, Takahiro Arakawa, Yasuhiko Iwasaki, and Kohji Mitsubayashi
ACS Sensors, 2018
Kenta Iitani, Toshiyuki Sato, Munire Naisierding, Yuuki Hayakawa, Koji Toma, Takahiro Arakawa, and Kohji Mitsubayashi
The Analyst, 2017
Weizhong Wang, Yan Yu, Xiuqing Zhang, and Xiangmin Tong
Anal. Methods, 2017, Volume 9, Number 21, Page 3085
Ewelina P. Dutkiewicz and Pawel L. Urban
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2016, Volume 374, Number 2079, Page 20150380
Nuria Queralto, Anders N Berliner, Brett Goldsmith, Raymond Martino, Paul Rhodes, and Sung H Lim
Journal of Breath Research, 2014, Volume 8, Number 2, Page 027112
Stefan Hanf, Robert Keiner, Di Yan, Jürgen Popp, and Torsten Frosch
Analytical Chemistry, 2014, Volume 86, Number 11, Page 5278
Hiroyuki Kataoka, Keita Saito, Hisato Kato, and Kazufumi Masuda
Bioanalysis, 2013, Volume 5, Number 11, Page 1443

Comments (0)

Please log in or register to comment.
Log in