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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2017: 3.556

CiteScore 2018: 2.44

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1437-4331
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Volume 50, Issue 12

Issues

Vitamin D deficiency parallels inflammation and immune activation, the Ludwigshafen Risk and Cardiovascular Health (LURIC) study

Christian Murr / Stefan Pilz
  • Division of Endocrinology and Metabolism, Department of Internal Medicine, Graz Medical University, Graz, Austria
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/ Tanja B. Grammer
  • Mannheim Medical Faculty, Mannheim Institute of Public Health, Social and Preventive Medicine, University of Heidelberg, Mannheim, Germany
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/ Marcus E. Kleber
  • Mannheim Medical Faculty, Mannheim Institute of Public Health, Social and Preventive Medicine, University of Heidelberg, Mannheim, Germany
  • LURIC Study Nonprofit LLC, Freiburg, Germany
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/ Andreas Meinitzer
  • Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
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/ Bernhard O. Boehm
  • Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, Ulm, Germany
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/ Winfried März
  • Mannheim Medical Faculty, Mannheim Institute of Public Health, Social and Preventive Medicine, University of Heidelberg, Mannheim, Germany
  • Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
  • Synlab Center of Laboratory Diagnostics Heidelberg, Heidelberg, Germany
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/ Dietmar Fuchs
Published Online: 2012-07-13 | DOI: https://doi.org/10.1515/cclm-2012-0157

Abstract

Background: Low vitamin D concentrations are detected in patients suffering from various clinical conditions which are characterized also by inflammation and immune activation. We investigated whether vitamin D levels in patients with coronary artery disease (CAD) are related to markers of immune activation.

Methods: Serum concentrations of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] and the immune activation markers neopterin and high sensitivity C-reactive protein (hsCRP) were measured in 2015 patients derived from the LUdwigshafen RIsk and Cardiovascular Health (LURIC) study, a cohort study among patients referred for coronary angiography.

Results: Serum concentrations of 25(OH)D and 1,25(OH)2D did not differ between patients with CAD [mean±SD: 25(OH)D: 17.4±9.4 μg/L; 1,25(OH)2D: 34.4±13.3 ng/L] and controls [25(OH)D: 18.4±11.7 μg/L; 1,25(OH)2D: 35.3±12.7 ng/L; Welch’s t-test: p=n.s.] but CAD patients had higher neopterin (8.6±7.4 nmol/L) and hsCRP (9.6±19.6 mg/L) concentrations compared to controls (neopterin: 7.5±4.8 nmol/L; p=0.0004; hsCRP: 5.4±10.0 mg/L; p<0.0001). There was an inverse correlation between serum 25(OH)D or 1,25(OH)2D concentrations and serum neopterin [Spearman’s rank correlation: 25(OH)D: rs=–0.183; 1,25(OH)2D: rs=–0.230] and hsCRP [25(OH)D: rs=–0.142; 1,25(OH)2D: rs=–0.130; all p<0.0001] concentrations.

Conclusions: Our results indicate increased inflammatory processes in patients with low vitamin D status. Further studies should clarify the underlying mechanisms for the observed associations of vitamin D status and inflammatory parameters.

Keywords: coronary artery disease; creatinine; C-reactive protein; cystatin C; neopterin; vitamin D

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About the article

Corresponding author: Dietmar Fuchs, Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innrain 80, 6020 Innsbruck, Austria Phone: +43 512 9003 70350, Fax: +43 512 9003 73330


Received: 2012-03-14

Accepted: 2012-06-14

Published Online: 2012-07-13

Published in Print: 2012-12-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 50, Issue 12, Pages 2205–2212, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2012-0157.

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