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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

Online
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1437-4331
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Volume 50, Issue 2 (Feb 2012)

Issues

Gold nanoparticles in the clinical laboratory: principles of preparation and applications

Hassan M.E. Azzazy
  • Yousef Jameel Science and Technology Research Center, The American University in Cairo, New Cairo, Egypt
  • Department of Chemistry, The American University in Cairo, New Cairo, Egypt
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mai M.H. Mansour
  • Yousef Jameel Science and Technology Research Center, The American University in Cairo, New Cairo, Egypt
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/ Tamer M. Samir
  • Yousef Jameel Science and Technology Research Center, The American University in Cairo, New Cairo, Egypt
  • Faculty of Pharmacy, Misr University for Science and Technology, October City, Egypt
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/ Ricardo Franco
  • REQUIMTE, Departmento de Química, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, Campus de Caparica, Lisboa, Portugal
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Published Online: 2011-10-06 | DOI: https://doi.org/10.1515/cclm.2011.732

Abstract

In order to meet the challenges of effective healthcare, the clinical laboratory is constantly striving to improve testing sensitivity while reducing the required time and cost. Gold nanoparticles (AuNPs) are proposed as one of the most promising tools to meet such goals. They have unique optophysical properties which enable sensitive detection of biomarkers, and are easily amenable to modification for use in different assay formats including immunoassays and molecular assays. Additionally, their preparation is relatively simple and their detection methods are quite versatile. AuNPs are showing substantial promise for effective practical applications and commercial utilization is already underway. This article covers the principles of preparation of AuNPs and their use for development of different diagnostic platforms.

Keywords: assay; bio-barcode; diagnostics; gold nanoparticles; immunoassay; molecular assay; nanomedicine

About the article

Corresponding author: Dr. Hassan M.E. Azzazy, The American University in Cairo, P.O. Box 74, New Cairo, 11835, Egypt Phone: +202 2615-2559, Fax: +202 2795 7565


Received: 2011-01-23

Accepted: 2011-08-28

Published Online: 2011-10-06

Published in Print: 2012-02-01


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm.2011.732.

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©2012 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

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