Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 50, Issue 2 (Feb 2012)

Issues

Gender- and obesity-specific effect of apolipoprotein C3 gene (APOC3) –482C>T polymorphism on triglyceride concentration in Turkish adults

Neslihan Coban
  • Department of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
/ Altan Onat
  • Department of Cardiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
/ Filiz Guclu-Geyik
  • Department of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
/ Evrim Komurcu-Bayrak
  • Department of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
/ Vedat Sansoy
  • Department of Cardiology, Institute of Cardiology, Istanbul University, Istanbul, Turkey
/ Gulay Hergenc
  • Department of Biology, Yildiz Technical University, Istanbul, Turkey
/ Günay Can
  • Department of Public Health, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
/ Nihan Erginel-Unaltuna
  • Department of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
  • Email:
Published Online: 2011-10-18 | DOI: https://doi.org/10.1515/cclm.2011.747

Abstract

Background: Apolipoprotein C3 (APOC3) gene polymorphisms are associated with cardiometabolic risk factors, varying in ethnicities. This study aimed to investigate such association between the APOC3 –482C>T polymorphism and cardiometabolic risk factors in the turkish adult risk factor (TARF) study cohort, stratifying by gender and obesity.

Methods: Randomly selected 1548 individuals (757 male and 791 female, mean age 49.9±11.8 years) were genotyped for –482C>T polymorphism using hybridization probes in a Real-Time PCR LC480 device.

Results: The –482TT genotype prevailed 9.9% in men and 11.5% in women. Association between 482C>T polymorphism and dyslipidemia (p=0.036, OR=1.42, 95%Cl=1.02–1.97) was found only in men. Analysis of variance showed that anthropometric and metabolic variables were not differently distributed in APOC3 –482C>T genotypes in the study population. In relation to dyslipidemia and obesity, the –482C>T polymorphism showed significant gender-by-genotype interactions (p<0.01). When the study population was stratified according to gender and obesity, homozygotes for the T allele were associated strongly with (by 45%) elevated fasting triglyceride concentrations in obese men (p=0.009) and homeostatic model assessment (HOMA) index in non-obese women (p=0.013). Furthermore, in the same subgroups, the associations of the fasting triglyceride concentrations and HOMA index with the TT genotype remained after adjustment for risk factors (p<0.05).

Conclusions: APOC3 –482TT genotype is independently associated with elevated fasting triglyceride concentrations in obese men. Presence of obesity seems to be required for this genotype to induce markedly elevated triglycerides. Furthermore, it is associated with the dyslipidemia in men, without requirement of obesity.

Keywords: apolipoprotein C3 –482C>T polymorphism; fasting triglyceride; gender difference; obesity; Turkish population.

About the article

Corresponding author: Nihan Erginel-Unaltuna, PhD, Department of Genetics, Institute for Experimental Medical Research, Istanbul University, Vakif Gureba Cad. Sehremini, Istanbul, Turkey Phone: +90-212-4142200-33316, Fax: +90-212-5324171


Received: 2011-03-29

Accepted: 2011-09-14

Published Online: 2011-10-18

Published in Print: 2012-02-01


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm.2011.747.

Export Citation

©2012 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

Comments (0)

Please log in or register to comment.
Log in