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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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Evaluation of nucleated red blood cells in the peripheral blood of hematological diseases

Paolo Danise
  • Department of Oncology Hematology, ASL Salerno 1, Salerno, Italy
/ Mariacaterina Maconi
  • Department of Clinical Pathology, ASL Alessandria, Alessandria, Italy
  • :
/ Fabio Barrella
  • Department of Oncology Hematology, ASL Salerno 1, Salerno, Italy
/ Anna Di Palma
  • Department of Oncology Hematology, ASL Salerno 1, Salerno, Italy
/ Daniela Avino
  • Department of Oncology Hematology, ASL Salerno 1, Salerno, Italy
/ Adele Rovetti
  • Department of Oncology Hematology, ASL Salerno 1, Salerno, Italy
/ Maria Gioia
  • Department of Clinical Pathology, “V. Cervello” Hospital, Palermo, Italy
/ Giovanni Amendola
  • Department of Pediatrics and Intensive Care Unit, Nocera Inferiore Hospital, Salerno, Italy
Published Online: 2011-10-25 | DOI: https://doi.org/10.1515/cclm.2011.766


Background: Nucleated red blood cells (NRBCs) are present in the peripheral blood of several hematological and non-hematological conditions, usually associated with bad prognosis. The lack of an easy, rapid and reliable NRBCs count method did no’t allow one to know the incidence of NRBCs and to quantify them: the count was usually done during the microscopic revision of a blood smear; this is the reason we found few studies on NRBCs automated count in the literature. The aim of this study was the evaluation of the presence and the quantification of NRBCs in some onco-hematological disorders.

Methods: This study analyzed 478 patients with the automated hematology analyzer Sysmex XE2100. The range of NRBCs were calculated in the peripheral blood at diagnosis, at hematological remission and during therapy.

Results: NRBCs are present in the peripheral blood of a high number of hematological diseases and are related to ineffective erythropoiesis or stress erythropoiesis or primary alterations of hematopoiesis. NRBCs were found in nearly all onco-hematological diseases at diagnosis, but not in all patients. NRBCs were frequently found during chemotherapy and absent at remission.

Conclusions: To the authors’ knowledge, this is the first study that gives a range for NRBCs count in the peripheral blood of these diseases.

Keywords: blood cell count; hematological diseases; nucleated red blood cells; peripheral blood

Corresponding author: Mariacaterina Maconi, MD, Department of Clinical Pathology, ASLAL P.zza Cavallotti, 7, 15057 Tortona, Alessandria, Italy Phone: +39-3407053321, Fax: +39-0131-865688

Received: 2011-08-22

Accepted: 2011-10-03

Published Online: 2011-10-25

Published in Print: 2012-02-01

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM). Volume 50, Issue 2, Pages 357–360, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm.2011.766, October 2011

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