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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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1437-4331
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First trimester biochemistry at different maternal ages

Jenni K. Ranta
  • Department of Clinical Chemistry, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
  • Eastern Finland Laboratory Centre, Kuopio, Finland
/ Jaana Marttala
  • Department of Obstetrics and Gynaecology, Oulu University Hospital, Oulu, Finland
/ Päivi Laitinen
  • Department of Obstetrics and Gynaecology, Oulu University Hospital, Oulu, Finland
  • Central Ostrobothnia Hospital District, Kokkola, Finland
/ Johanna Kultti
  • Laboratory, Seinäjoki Central Hospital, Seinäjoki, Finland
/ Olavi Kauhanen
  • Department of Obstetrics and Gynaecology, Kuopio University Hospital, Kuopio, Finland
/ Jarkko Romppanen
  • Department of Clinical Chemistry, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
  • Eastern Finland Laboratory Centre, Kuopio, Finland
/ Esa Hämäläinen
  • Department of Clinical Chemistry, University of Helsinki, Helsinki, Finland
  • HUSLAB, Women’s Clinic Laboratory, Helsinki Central University Hospital, Helsinki, Finland
/ Seppo Heinonen
  • Department of Obstetrics and Gynaecology, Kuopio University Hospital, Kuopio, Finland
  • Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
/ Kari Pulkki
  • Department of Clinical Chemistry, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
  • Eastern Finland Laboratory Centre, Kuopio, Finland
/ Markku Ryynänen
  • Department of Obstetrics and Gynaecology, Oulu University Hospital, Oulu, Finland
  • :
Published Online: 2011-11-24 | DOI: https://doi.org/10.1515/cclm.2011.785

Abstract

Background: The performance of first trimester biochemical screening was compared at different pregnancy weeks and maternal ages during 2002–2008 in a screened population of 76,949 women.

Methods: The detection rates, as well as the median multiples of a median (MOMs) of free β-human chorionic gonadotropin (free β-hCG) and pregnancy-associated plasma protein-A (PAPP-A), were compared between completed gestational weeks 8–13 and between different maternal ages separated into 5-year groupings.

Results: The number of singleton Down syndrome pregnancies was 221. The median age of the screened women was 30 years and the proportion of women aged ≥35 years 16.9%. The median age of the women with a Down syndrome pregnancy was 37 years. In women aged <35 years, the biochemical markers provided a detection rate of only 38.6%, whereas in women aged ≥35 years, the biochemical markers detected 82.7% of cases (p<0.01).

Conclusions: Biochemical screening works best amongst women aged ≥35 years. For younger mothers aged <35 years, combined screening should be the method of choice.

Keywords: Down syndrome; first trimester; free β-hCG; gestational age; maternal age; PAPP-A; screening

Corresponding author: Markku Ryynänen, Department of Obstetrics and Gynaecology, Oulu University Hospital, P.O. Box 24, 90020 Oys, Finland Phone: +358 8 315 3171, Fax: +358 8 315 4310


Received: 2011-08-22

Accepted: 2011-10-19

Published Online: 2011-11-24

Published in Print: 2012-03-01


Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 50, Issue 3, Pages 549–555, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm.2011.785, November 2011

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