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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

Online
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1437-4331
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Volume 50, Issue 4 (Apr 2012)

Issues

Serum cystatin C is an early biomarker for assessment of renal function in burn patients

Xiaoyan Cai
  • Burns Department, the First People’s Hospital of Shunde (The Affiliated Hospital at Shunde, Southern Medical University), Foshan, P.R. China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Zhaolin Long / Lianduo Lin
  • Burns Department, the First People’s Hospital of Shunde (The Affiliated Hospital at Shunde, Southern Medical University), Foshan, P.R. China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Yudong Feng
  • Burns Department, the First People’s Hospital of Shunde (The Affiliated Hospital at Shunde, Southern Medical University), Foshan, P.R. China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Naxi Zhou
  • Burns Department, the First People’s Hospital of Shunde (The Affiliated Hospital at Shunde, Southern Medical University), Foshan, P.R. China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Qifeng Mai
  • Burns Department, the First People’s Hospital of Shunde (The Affiliated Hospital at Shunde, Southern Medical University), Foshan, P.R. China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-01-19 | DOI: https://doi.org/10.1515/cclm-2011-0838

Abstract

Background: Early detection of renal dysfunction is important in burn patients. This study evaluated whether serum cystatin C (CysC) is a potentially accurate and sensitive marker for identification of reduced glomerular filtration rate (GFR) and the risk factors of impaired renal function in major burn patients.

Methods: A total of 48 adult patients with major burn injury were enrolled. Renal function was assessed using serum creatinine (sCr), 24-h urinary creatinine clearance (24-hCrCl), sCr-based formulae and CysC-based formulae on the second day and seventh day post-burn.

Results: There was a high prevalence (27.1%) of acute impaired renal function in major burn patients in the first week post-burn. CysC-based formulae for estimated GFR (eGFR) are more accurate and sensitive for detection of impaired renal function than sCr-based formulae. Multivariate logistic regression analysis demonstrated that age (OR, 2.08; 95% CI 1.26–4.77) and the percentage of burn area (OR, 3.41; 95% CI 1.64–6.95) were independent risk factors of impaired renal function.

Conclusions: The results of this study suggest that CysC is a more accurate and sensitive marker for identification of acute impaired renal function in major burn patients than sCr. It is important to measure CysC and calculate eGFR to prevent acute renal failure and modify drug doses in burn patients, especially those of older age and with major burn areas.

Keywords: burn; cystatin C; glomerular filtration rate; serum creatinine

About the article

Corresponding author: Professor Zhaolin Long, Department of Urology, the First People’s Hospital of Shunde (The Affiliated Hospital at Shunde, Southern Medical University), Penglai Road, Daliang Town, Shunde District, Foshan, Guangdong 528300, P.R. China Phone: +86 757 22318701, Fax: +86 757 22223899


Received: 2011-11-19

Accepted: 2011-12-02

Published Online: 2012-01-19

Published in Print: 2012-04-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2011-0838.

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©2012 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

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