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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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1437-4331
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Volume 50, Issue 5

Issues

Faecal haemoglobin concentrations by gender and age: implications for population-based screening for colorectal cancer

Paula J. McDonald / Judith A. Strachan / Jayne Digby / Robert J.C. Steele
  • Scottish Bowel Screening Centre, Kings Cross, Dundee, Scotland, UK
  • Department of Surgery, University of Dundee, Dundee, Scotland, UK
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Callum G. Fraser
Published Online: 2011-12-07 | DOI: https://doi.org/10.1515/cclm.2011.815

Abstract

Background: Faecal immunochemical tests (FIT) are becoming widely used in colorectal cancer screening. Estimation of faecal haemoglobin concentration in a large group prompted an observational study on gender and age.

Methods: A single estimate of faecal haemoglobin concentration was made using quantitative automated immunoturbidimetry. Potential reference intervals were calculated for men and women and for age quintiles according to the Clinical and Laboratory Standards Institute Approved Guideline. The percentages of positive results were calculated at a number of concentrations. The percentages of individuals who fell into different risk groups were assessed.

Results: The 97.5 percentiles, potential upper reference limits, were 519 ng haemoglobin/mL (90% CI: 468–575) for men and 283 ng haemoglobin/mL (90% CI: 257–316) for women. Concentrations increased with age in both genders. Decision limits have advantages over reference intervals. At any cut-off concentration, more men are declared positive than women and more older people are declared positive than younger people. Future risk of neoplasia is higher in men than in women and in older people.

Conclusions: Faecal haemoglobin concentrations vary with gender and age. More tailored strategies are needed in screening programmes. Faecal haemoglobin concentration could be included in individual risk assessment scores. These data should assist in screening programme design.

Keywords: colorectal cancer; decision limits; faecal immunochemical test; reference values; screening

About the article

Corresponding author: Callum G. Fraser, PhD, Centre for Research into Cancer Prevention and Screening, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK Phone: +44 1382553799, Fax: +44 1382425679


Received: 2011-10-03

Accepted: 2011-11-11

Published Online: 2011-12-07

Published in Print: 2012-05-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 50, Issue 5, Pages 935–940, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm.2011.815.

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