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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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1437-4331
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Volume 50, Issue 7 (Jul 2012)

Issues

Recommendations on prenatal screening and the connections to other diseases such as thyroid dysfunction

Drahomira Springer
  • Institute of Clinical Biochemistry and Laboratory Medicine, First Faculty of Medicine Charles University and General University Hospital, Prague, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Eliska Potlukova
  • Third Medical Department, Department of Endocrinology and Metabolism, First Faculty of Medicine Charles University and General University Hospital, Prague, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Zdenka Limanova
  • Third Medical Department, Department of Endocrinology and Metabolism, First Faculty of Medicine Charles University and General University Hospital, Prague, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Tomas Zima
  • Corresponding author
  • Institute of Clinical Biochemistry and Laboratory Medicine, First Faculty of Medicine Charles University and General University Hospital, Prague, Czech Republic
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  • Other articles by this author:
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Published Online: 2012-03-22 | DOI: https://doi.org/10.1515/cclm-2011-0598

Abstract

The aim of general maternal-foetal care is to ensure an uncomplicated birth of a healthy baby to a healthy mother. There is a large range of screening tests used during pregnancy: for gestational diabetes, infection, rhesus-D status, thyroid dysfunction, as well as other tests. An important part of prenatal care is the screening of major aneuploidies, primarily for Down’s syndrome. This screening is possible in either the first or second trimester, or in both. Management of this type of screening is very similar around the world. Hypothyroidism can affect the psychomotor development of the child. Thyroid-stimulating hormone (TSH), autoantibodies against thyroperoxidase (TPOAb), and free thyroxin (FT4) were determined within our group of 7530 pregnant women. Elevated concentrations of TSH were found in 5.1%, suppression was found in 2.9% and 11.5% were TPOAb positive. Either a familial or personal history of thyroid or autoimmune diseases was present in 58.3% of those women who tested positive on any thyroid test. At minimum, 40% of women TPOAb positive during pregnancy have some kind of thyroid disorders after delivery. These results support the efficacy of general thyroid function screening in early pregnancy, as well as the follow-up after delivery of those women who are positive.

Keywords: Down’s syndrome; prenatal screening; thyroid disease

About the article

Drahomira Springer

Drahomíra Springer, Ing, PhD. (1961)

Drahomíra Springer graduated at the University of Chemical Technology, majoring in Biochemistry in 1985. She has worked at the Institute of Medical Biochemistry and Laboratory Medicine of the General University Hospital in Prague since 1985. Her area of interest is above all pregnancy, screening of chromosomal aberration and thyroid disease in pregnancy. Since 1999 she has been Assistant Professor at the First Faculty of Medicine, Charles University Prague. She is author of more than 20 articles and co-author of six chapters in books.

Eliska Potlukova

Eliska Potlukova, MD, PhD (1977)

Eliska Potlukova graduated from the First Faculty of Medicine of the Charles University in Prague in 2001. During studies, she spent 6 months at the Yale School of Medicine (USA). After graduation, she worked and studied for more than 2 years at the University Hospital Basel in Switzerland. Since 2004, she has been working at the Third Department of Medicine of the General University Hospital in Prague as teacher, scientist and physician (internal medicine, endocrinology).

Zdenka Limanova

Zdenka Limanova, MD, CSc. (1938)

Zdenka Limanova graduated and is currently an Associate Professor at the First Faculty of Medicine, Charles University, Prague. She works at the Third Department of Medicine of the General University Hospital in Prague. Her area of interest is above all thyroid disorders. At the beginning of the 1970s, she introduced and pushed through the wide use of fine-needle aspiration biopsy and cytology. In recent years she has dedicated herself to the issue of thyroid disease in pregnancy and advocates universal screening of the functional thyroid disorders in pregnancy. She is the author of over 180 specialist articles, as well as the author and co-author of several monographs. She is a member Committee of the Czech Endocrinology Society.

Tomas Zima

Prof. Tomas ZIMA, MD, DSc. (1966)

Prof. Tomas graduated at the First Faculty of Medicine, Charles University, Prague in 1990 and has been Professor of Medical Chemistry and Biochemistry from 2001 and Head of Institute of Medical Biochemistry and Laboratory Medicine from 1999. Since 2005, he has been the Dean of the First Faculty of Medicine, Charles University. His main research interests include oxidative stress, AGE’s, experimental nephrology, tumour markers, and laboratory management and accreditation. He is author of more than 300 articles, author of five books and co-author of 56 chapters in books. He is the Editor in Chief of Folia Biologica and Addictology. Prof. Zima has been a member in many learned societies and their Boards (e.g., Executive Board EFCC and president of Czech Society of Clinical Biochemistry).


Corresponding author: Prof. Tomas Zima, MD, Dr Sc Institute of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University, U Nemocnice 2 121 08, Prague 2, Czech Republic Phone: +420 224962841, Fax: +420 224962848


Received: 2011-08-31

Accepted: 2012-02-29

Published Online: 2012-03-22

Published in Print: 2012-07-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2011-0598.

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