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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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Recommendations on prenatal screening and the connections to other diseases such as thyroid dysfunction

Drahomira Springer1 / Eliska Potlukova2 / Zdenka Limanova2 / 1

1Institute of Clinical Biochemistry and Laboratory Medicine, First Faculty of Medicine Charles University and General University Hospital, Prague, Czech Republic

2Third Medical Department, Department of Endocrinology and Metabolism, First Faculty of Medicine Charles University and General University Hospital, Prague, Czech Republic

Corresponding author: Prof. Tomas Zima, MD, Dr Sc Institute of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University, U Nemocnice 2 121 08, Prague 2, Czech Republic Phone: +420 224962841, Fax: +420 224962848

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 50, Issue 7, Pages 1211–1220, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/cclm-2011-0598, March 2012

Publication History

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The aim of general maternal-foetal care is to ensure an uncomplicated birth of a healthy baby to a healthy mother. There is a large range of screening tests used during pregnancy: for gestational diabetes, infection, rhesus-D status, thyroid dysfunction, as well as other tests. An important part of prenatal care is the screening of major aneuploidies, primarily for Down’s syndrome. This screening is possible in either the first or second trimester, or in both. Management of this type of screening is very similar around the world. Hypothyroidism can affect the psychomotor development of the child. Thyroid-stimulating hormone (TSH), autoantibodies against thyroperoxidase (TPOAb), and free thyroxin (FT4) were determined within our group of 7530 pregnant women. Elevated concentrations of TSH were found in 5.1%, suppression was found in 2.9% and 11.5% were TPOAb positive. Either a familial or personal history of thyroid or autoimmune diseases was present in 58.3% of those women who tested positive on any thyroid test. At minimum, 40% of women TPOAb positive during pregnancy have some kind of thyroid disorders after delivery. These results support the efficacy of general thyroid function screening in early pregnancy, as well as the follow-up after delivery of those women who are positive.

Keywords: Down’s syndrome; prenatal screening; thyroid disease

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