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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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1437-4331
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Volume 50, Issue 8

Issues

Behavioral and clinical correlates of high-sensitivity C-reactive protein in Japanese men and women

Akie Hirata
  • Corresponding author
  • Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
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/ Keizo Ohnaka
  • Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
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/ Makiko Morita
  • Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
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/ Kengo Toyomura
  • Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
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/ Suminori Kono
  • Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
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/ Ken Yamamoto
  • Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
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/ Masahiro Adachi
  • Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
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/ Hisaya Kawate
  • Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
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/ Ryoichi Takayanagi
  • Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
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Published Online: 2012-02-23 | DOI: https://doi.org/10.1515/cclm-2011-0839

Abstract

Background: Inflammation has been implicated in the pathogenesis of cardiovascular disease, type 2 diabetes mellitus and cancer. Serum concentration of high-sensitivity C-reactive protein is a good biomarker of chronic low-grade inflammation. Few studies have evaluated relative importance of behavioral and clinical covariates of high-sensitivity C-reactive protein in Japanese population.

Methods: The study subjects were men and women aged 49–76 years from the cohort study of lifestyle-related diseases between February 2004 and July 2006. Analysis of covariance and multiple linear regression analysis were used to estimate geometric means of high-sensitivity C-reactive protein and trends of association.

Results: Smoking, body mass index, hypertension, type 2 diabetes mellitus, elevated non-high density lipoprotein cholesterol, prudent dietary pattern were independently associated with serum high-sensitivity C-reactive protein in both men and women. High-sensitivity C-reactive protein concentrations were lowest in men with a moderate intake of alcohol (<30 mL/day). In men, smoking and body mass index accounted for 28% and 26% of the variation in high-sensitivity C-reactive protein, respectively, while body mass index accounted for 60% of the variation of high-sensitivity C-reactive protein in women.

Conclusions: Smoking and body mass index in men, and body mass index in women, were major correlates of serum high-sensitivity C-reactive protein in Japanese people.

Keywords: alcohol intake; body mass index; high-sensitivity C-reactive protein; smoking

About the article

Corresponding author: Akie Hirata, Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan Phone: +81-92-642-6113, Fax: +81-92-642-6115


Received: 2011-11-21

Accepted: 2012-01-24

Published Online: 2012-02-23

Published in Print: 2012-08-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 50, Issue 8, Pages 1469–1476, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2011-0839.

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