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Licensed Unlicensed Requires Authentication Published by De Gruyter February 23, 2012

Behavioral and clinical correlates of high-sensitivity C-reactive protein in Japanese men and women

  • Akie Hirata EMAIL logo , Keizo Ohnaka , Makiko Morita , Kengo Toyomura , Suminori Kono , Ken Yamamoto , Masahiro Adachi , Hisaya Kawate and Ryoichi Takayanagi

Abstract

Background: Inflammation has been implicated in the pathogenesis of cardiovascular disease, type 2 diabetes mellitus and cancer. Serum concentration of high-sensitivity C-reactive protein is a good biomarker of chronic low-grade inflammation. Few studies have evaluated relative importance of behavioral and clinical covariates of high-sensitivity C-reactive protein in Japanese population.

Methods: The study subjects were men and women aged 49–76 years from the cohort study of lifestyle-related diseases between February 2004 and July 2006. Analysis of covariance and multiple linear regression analysis were used to estimate geometric means of high-sensitivity C-reactive protein and trends of association.

Results: Smoking, body mass index, hypertension, type 2 diabetes mellitus, elevated non-high density lipoprotein cholesterol, prudent dietary pattern were independently associated with serum high-sensitivity C-reactive protein in both men and women. High-sensitivity C-reactive protein concentrations were lowest in men with a moderate intake of alcohol (<30 mL/day). In men, smoking and body mass index accounted for 28% and 26% of the variation in high-sensitivity C-reactive protein, respectively, while body mass index accounted for 60% of the variation of high-sensitivity C-reactive protein in women.

Conclusions: Smoking and body mass index in men, and body mass index in women, were major correlates of serum high-sensitivity C-reactive protein in Japanese people.


Corresponding author: Akie Hirata, Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan Phone: +81-92-642-6113, Fax: +81-92-642-6115

Received: 2011-11-21
Accepted: 2012-1-24
Published Online: 2012-02-23
Published in Print: 2012-08-01

©2012 by Walter de Gruyter Berlin Boston

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