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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

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1437-4331
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Volume 50, Issue 8

Issues

Oxidative stress as a predictor of cardiovascular events in coronary artery disease patients

Cristina Vassalle
  • Corresponding author
  • Fondazione G.Monasterio CNR-Regione Toscana and Institute of Clinical Physiology-CNR, Pisa, Italy
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  • De Gruyter OnlineGoogle Scholar
/ Sara Bianchi
  • Fondazione G.Monasterio CNR-Regione Toscana and Institute of Clinical Physiology-CNR, Pisa, Italy
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/ Fabrizio Bianchi
  • Fondazione G.Monasterio CNR-Regione Toscana and Institute of Clinical Physiology-CNR, Pisa, Italy
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  • De Gruyter OnlineGoogle Scholar
/ Patrizia Landi
  • Fondazione G.Monasterio CNR-Regione Toscana and Institute of Clinical Physiology-CNR, Pisa, Italy
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/ Debora Battaglia
  • Fondazione G.Monasterio CNR-Regione Toscana and Institute of Clinical Physiology-CNR, Pisa, Italy
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  • De Gruyter OnlineGoogle Scholar
/ Clara Carpeggiani
  • Fondazione G.Monasterio CNR-Regione Toscana and Institute of Clinical Physiology-CNR, Pisa, Italy
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  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-02-28 | DOI: https://doi.org/10.1515/cclm-2011-0919

Abstract

Background: Enhanced oxidative stress has been associated with atherosclerosis and coronary artery disease (CAD). However, the predictive value of circulating oxidative stress biomarkers for cardiovascular events (CE) in patients with CAD has remained poorly understood.

Aim: To assess the prognostic significance of reactive oxygen metabolites, estimated as index of oxidative stress in serum samples by means of a commercial kit (ROMs, Diacron, Italy) on the rate of mortality and major adverse CE (MACE) in CAD.

Methods: A study of 93 consecutive patients with angiographically documented CAD (75 males, age: 68±10 years, mean±SD) was made during a mean follow-up of 66 months until the occurrence of one of the following CE: cardiac and all cause death, non-fatal myocardial infarction and coronary revascularization [percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass grafting (CABG)]. Patient data were retrospectively collected from the Institute’s electronic databank that saves demographic, clinical, instrumental and follow-up data of all patients admitted to our department.

Results: The Kaplan-Meier survival estimates showed a significantly worst outcome in patients presenting elevated ROM level (>75th percentile, corresponding to 481 AU) (log rank=11, 7.5, 5.1; p<0.001, p<0.01, p<0.05 for cardiac and all cause death and MACEs, respectively). In a multivariate Cox regression model, elevated oxidative stress remained a significant predictor of cardiac and all cause death [hazard ratio (HR) 3.9, 95% confidence interval, 95% (CI) 1.4–11.1, p=0.01; HR=2.6, 95% CI 1.1–6.2, p=0.02) and MACE (HR=1.8, 95% CI 1.1–3.1, p=0.03)].

Conclusions: The estimation of ROMs may represent an additional prognostic tool in the assessment of CE in CAD patients.

Keywords: atherosclerosis; cardiovascular events; coronary artery disease; follow-up; oxidative stress

About the article

Corresponding author: Dr. Cristina Vassalle, PhD, Fondazione G.Monasterio CNR-Regione Toscana and Istituto di Fisiologia Clinica-CNR, Via Moruzzi 1, I-56124, Pisa, Italy Phone: +39-050-3152199, Fax:+39-050-3152166


Received: 2011-12-13

Accepted: 2012-01-24

Published Online: 2012-02-28

Published in Print: 2012-08-01


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 50, Issue 8, Pages 1463–1468, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2011-0919.

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