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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Volume 50, Issue 9

Issues

Clinical and pathological features of B-cell non-Hodgkin lymphomas lacking the surface expression of immunoglobulin light chains

Hiromichi Matsushita
  • Corresponding author
  • Department of Laboratory Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
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/ Naoya Nakamura / Yuzo Tanaka
  • Department of Laboratory Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
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/ Daisuke Ohgiya
  • Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
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/ Yumiko Tanaka
  • Department of Laboratory Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
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/ Anar Damdinsuren
  • Department of Laboratory Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
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/ Satomi Asai
  • Department of Laboratory Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
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/ Miharu Yabe
  • Department of Laboratory Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
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/ Hiroshi Kawada
  • Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
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/ Yoshiaki Ogawa
  • Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
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/ Kiyoshi Ando
  • Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
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/ Hayato Miyachi
  • Department of Laboratory Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
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Published Online: 2012-03-16 | DOI: https://doi.org/10.1515/cclm-2011-1854

Abstract

Background: The flow cytometric analysis of surface immunoglobulin light chains (sIgL) is used as a simple method for evaluating monoclonal B-cell proliferation. However, the sIgL expression, κ or λ, is occasionally undetectable in cases with B-cell non-Hodgkin lymphomas (B-NHL). The purpose of this study was to investigate the clinical and pathological characteristics of these B-NHL cases.

Methods: We retrospectively analyzed 50 cases with previously untreated sIgL-negative B-NHL. All of these cases had been diagnosed at Tokai University Hospital between January 2001 and February 2011. Their medical charts were reviewed.

Results: These cases had several clinical features: diffuse large B-cell lymphoma (DLBCL) (72%), a high serum lactate dehydrogenase level (66%), clinical stage III and IV (68%), and complex karyotypes (58%). Seven out of eight evaluated patients (87%) did not express cytoplasmic IgL, and the DNA rearrangement pattern of IgL showed diversity in 10 analyzed patients. The 5-year event-free survival of all the sIgL-negative B-NHL cases was significantly better with rituximab-containing chemotherapies in comparison to the regimens without it (57.9% vs. 17.9%, p=0.0207), although there was no statistical significance when the DLBCL cases were analyzed (56.6% vs. 22.2%, p=0.1530).

Conclusions: These findings suggest that sIgL-negative B-NHL cases predominantly developed DLBCL in advanced disease, but were heterogeneous at the molecular level.

Keywords: diffuse large B-cell lymphoma; non-Hodgkin lymphoma; rituximab; southern blotting analysis; surface immunoglobulin light chains

About the article

Corresponding author: Hiromichi Matsushita, MD, PhD, Department of Laboratory Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan Phone: +81 463 931121, Fax: +81 463 938607


Received: 2011-11-17

Accepted: 2012-02-21

Published Online: 2012-03-16

Published in Print: 2012-09-01


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 50, Issue 9, Pages 1665–1670, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2011-1854.

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