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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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IMPACT FACTOR 2016: 3.432

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1437-4331
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Volume 51, Issue 10 (Oct 2013)

Issues

Presepsin (sCD14-ST) in preoperative diagnosis of abdominal sepsis

Tatjana Vodnik / Goran Kaljevic / Tanja Tadic / Nada Majkic-Singh
  • Institute of Medical Biochemistry, School of Pharmacy, University of Belgrade, Belgrade, Serbia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2013-06-05 | DOI: https://doi.org/10.1515/cclm-2013-0061

Abstract

Background: The aim of the study was to identify the diagnostic significance of presepsin in acute abdominal conditions and also to examine the correlation between presepsin, procalcitonin (PCT) and other parameters.

Methods: To detect presepsin we used a new rapid method based on a chemiluminescent enzyme immunoassay. The clinical usefulness of presepsin to differentiate bacterial and non-bacterial infection [including systemic inflammation response syndrome (SIRS)] was studied and compared with PCT, C-reactive protein (CRP) and white blood cells (WBC).

Results: The presepsin values in different conditions were (mean±standard deviation): healthy group (n=70) 258.7±92.53 pg/mL; SIRS (n=30) 430.0±141.33 pg/mL; sepsis (n=30) 1508.3±866.6 pg/mL. The presepsin values were significantly higher in patients with sepsis than the SIRS group (p<0.0001, Mann-Whitney U-test). The area under the receiver operating characteristics (ROC) curve (AUC) for discriminating of the SIRS from the sepsis patients was 0.996 for presepsin and it was greater than the AUC of PCT (0.912), CRP (0.857) or WBC (0.777).

Conclusions: The ROC curve of the SIRS patient without infection and the sepsis patient showed that the presepsin concentration was a significantly sensitive indicator of sepsis and useful marker for the rapid diagnosis of sepsis.

Keywords: infection; presepsin; procalcitonin; ROC curve; sepsis

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About the article

Corresponding author: Prim MSc Tatjana Vodnik, Center for Medical Biochemistry, Clinical Center of Serbia, Višegradska 26, 11000 Belgrade, Serbia, E-mail:


Received: 2013-01-23

Accepted: 2013-05-14

Published Online: 2013-06-05

Published in Print: 2013-10-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2013-0061.

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©2013 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

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