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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Volume 51, Issue 6 (Jun 2013)

Issues

Coffee consumption, serum γ-glutamyltransferase, and glucose tolerance status in middle-aged Japanese men

Tatsuo Hiramatsu
  • Corresponding author
  • Department of Preventive Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
  • Email:
/ Osamu Tajima
  • Department of Preventive Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
  • Self-Defense Forces Kumamoto Hospital, Kumamoto, Japan
/ Kousaku Uezono
  • Department of Preventive Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
  • Self-Defense Forces Kumamoto Hospital, Kumamoto, Japan
/ Shinji Tabata
  • Self-Defense Forces Fukuoka Hospital, Kasuga-shi, Japan
/ Hiroshi Abe
  • Self-Defense Forces Fukuoka Hospital, Kasuga-shi, Japan
/ Keizo Ohnaka
  • Department of Geriatric Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
/ Suminori Kono
  • Department of Preventive Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Published Online: 2012-12-25 | DOI: https://doi.org/10.1515/cclm-2012-0700

Abstract

Background: Recently, coffee consumption has been related to decreased risk of type 2 diabetes mellitus (DM) among those with high levels of serum γ-glutamyltransferase (GGT). We examined the association between coffee and glucose tolerance, determined by a 75 g oral glucose tolerance test, and the effect modification of serum GGT on the association.

Methods: The study subjects were 5320 men aged 46–60 years who received a health examination at two Self-Defense Forces hospitals from January 1997 to March 2004. Those medicated for DM were excluded. Coffee consumption was classified into <1, 1–2, 3–4, and ≥5 cups/day. Statistical adjustment was made for age, body mass index, smoking, alcohol use, leisure-time physical activity, green tea consumption, parental diabetes, hospital, and rank in the Self-Defense Forces.

Results: Men with normal glucose tolerance, isolated impaired fasting glucose (IFG), isolated impaired glucose tolerance (IGT), combined IFG/IGT, and type 2 DM numbered 3384, 398, 790, 348, and 400, respectively. The prevalence odds of isolated IGT, combined IFG/IGT, and type 2 DM, but not of isolated IFG, decreased with increasing consumption of coffee. An inverse association with coffee was observed for isolated IGT in both low (≤40 IU/L) and high (>40 IU/L) GGT groups, and for combined IFG/IGT and type 2 DM in the latter group.

Conclusions: Coffee drinking is protective against glucose intolerance. A possible effect modification of GGT on the coffee-DM association warrants further studies.

Keywords: coffee; diabetes mellitus, type 2; glucose intolerance; glucose tolerance test; γ-glutamyltransferase

References

  • 1.

    Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 2010;87:4–14.

  • 2.

    Hu FB. Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care 2011;34:1249–57. [PubMed]

  • 3.

    van Dam RM. The epidemiology of lifestyle and risk for type 2 diabetes. Eur J Epidemiol 2003;18:1115–25.

  • 4.

    van Dam RM, Feskens EJ. Coffee consumption and risk of type 2 diabetes mellitus. Lancet 2002;360:1477–8.

  • 5.

    van Dam RM, Hu FB. Coffee consumption and risk of type 2 diabetes: a systematic review. J Am Med Assoc 2005;294: 97–104.

  • 6.

    Huxley R, Lee CM, Barzi F, Timmermeister L, Czernichow S, Perkovic V, et al. Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysis. Arch Intern Med 2009;169:2053–63. [Web of Science] [PubMed]

  • 7.

    Agardh EE, Carlsson S, Ahlbom A, Efendic S, Grill V, Hammar N, et al. Coffee consumption, type 2 diabetes and impaired glucose tolerance in Swedish men and women. J Intern Med 2004;255:645–52. [PubMed]

  • 8.

    Yamaji T, Mizoue T, Tabata S, Ogawa S, Yamaguchi K, Shimizu E, et al. Coffee consumption and glucose tolerance status in middle-aged Japanese men. Diabetologia 2004;47:2145–51. [PubMed]

  • 9.

    van Dam RM, Dekker JM, Nijpels G, Stehouwer CD, Bouter LM, Heine RJ. Coffee consumption and incidence of impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes: the Hoorn Study. Diabetologia 2004;47:2152–9.

  • 10.

    Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes 2003;52:1–8. [PubMed]

  • 11.

    Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006;440:944–8. [PubMed]

  • 12.

    Higdon JV, Frei B. Coffee and health: a review of recent human research. Crit Rev Food Sci Nutr 2006;46:101–23. [Crossref]

  • 13.

    Natella F, Scaccini C. Role of coffee in modulation of diabetes risk. Nutr Rev 2012;70:207–17. [Web of Science] [Crossref]

  • 14.

    Tunnicliffe JM, Shearer J. Coffee, glucose homeostasis, and insulin resistance: physiological mechanisms and mediators. Appl Physiol Nutr Metab 2008;33:1290–300. [PubMed] [Web of Science]

  • 15.

    Lee DH, Silventoinen K, Jacobs DR, Jr., Jousilahti P, Tuomileto J. Gamma-Glutamyltransferase, obesity, and the risk of type 2 diabetes: observational cohort study among 20,158 middle-aged men and women. J Clin Endocrinol Metab 2004;89:5410–4.

  • 16.

    Fraser A, Harris R, Sattar N, Ebrahim S, Davey Smith G, Lawlor DA. Alanine aminotransferase, gamma-glutamyltransferase, and incident diabetes: the British Women’s Heart and Health Study and meta-analysis. Diabetes Care 2009;32:741–50. [PubMed]

  • 17.

    Targher G. Elevated serum gamma-glutamyltransferase activity is associated with increased risk of mortality, incident type 2 diabetes, cardiovascular events, chronic kidney disease and cancer – a narrative review. Clin Chem Lab Med 2010;48: 147–57. [PubMed] [Web of Science]

  • 18.

    Lim JS, Yang JH, Chun BY, Kam S, Jacobs DR, Jr., Lee DH. Is serum gamma-glutamyltransferase inversely associated with serum antioxidants as a marker of oxidative stress? Free Radic Biol Med 2004;37:1018–23.

  • 19.

    Lee DH, Jacobs DR, Jr. Serum gamma-glutamyltransferase: new insights about an old enzyme. J Epidemiol Community Health 2009;63:884–6. [PubMed] [Web of Science]

  • 20.

    Bidel S, Silventoinen K, Hu G, Lee DH, Kaprio J, Tuomilehto J. Coffee consumption, serum gamma-glutamyltransferase and risk of type II diabetes. Eur J Clin Nutr 2008;62:178–85. [Web of Science] [PubMed]

  • 21.

    Honjo S, Kono S, Coleman MP, Shinchi K, Sakurai Y, Todoroki I, et al. Coffee drinking and serum gamma-glutamyltransferase: an extended study of Self-Defense Officials of Japan. Ann Epidemiol 1999;9:325–31. [PubMed]

  • 22.

    Honjo S, Kono S, Coleman MP, Shinchi K, Sakurai Y, Todoroki I, et al. Coffee consumption and serum aminotransferases in middle-aged Japanese men. J Clin Epidemiol 2001;54:823–9. [PubMed]

  • 23.

    World Health Organization, International Diabetes Federation. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: report of a WHO/IDF consultation. Geneva: WHO Press, 2006:3.

  • 24.

    Ohmura T, Ueda K, Kiyohara Y, Kato I, Iwamoto H, Nakayama K, et al. Prevalence of type 2 (non-insulin-dependent) diabetes mellitus and impaired glucose tolerance in the Japanese general population: the Hisayama Study. Diabetologia 1993;36: 1198–203. [PubMed]

  • 25.

    Ministry of Health, Labor and Welfare, Japan. A report of the National Diabetes Survey, 2002. Tokyo: Ministry of Health, Labor and Welfare, Japan, 2004:20. [Japanese].

About the article

Corresponding author: Tatsuo Hiramatsu, MD, Department of Preventive Medicine, Kyushu University Graduate School of Medical Sciences, 3–1–1 Maidashi, Higashi-ku, Fukuoka 812–8582, Japan, Phone: +81 92 6426110, Fax: +81 92 6426115


Received: 2012-10-15

Accepted: 2012-11-26

Published Online: 2012-12-25

Published in Print: 2013-06-01


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2012-0700. Export Citation

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