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Volume 51, Issue 6 (Jun 2013)


Opinion paper on innovative approach of biomarkers for infectious diseases and sepsis management in the emergency department

Salvatore Di Somma
  • Corresponding author
  • Department of Medical-Surgery Sciences and Translational Medicine, University ‘Sapienza’ Rome, Sant’Andrea Hospital, Rome, Italy
  • Emergency Medicine Department, Sant’ Andrea Hospital, Via di Grottarossa 1035-1039, Rome 00189, Italy
  • Email:
/ Laura Magrini
  • Emergency Medicine Department, Sant’Andrea Hospital, University of Rome ‘Sapienza’ School of Medicine and Psychology, Rome, Italy
/ Francesco Travaglino
  • Emergency Medicine Department, Sant’Andrea Hospital, University of Rome ‘Sapienza’ School of Medicine and Psychology, Rome, Italy
/ Irene Lalle
  • Emergency Medicine Department, Sant’Andrea Hospital, University of Rome ‘Sapienza’ School of Medicine and Psychology, Rome, Italy
/ Nicola Fiotti
  • Emergency Medicine Department, University of Trieste, Trieste, Italy
/ Grianfranco Cervellin
  • Emergency Department, University Hospital of Parma, Parma, Italy
/ Gian Carlo Avanzi
  • Department of Translational Medicine, Eastern Piedmont University, Novara, Italy
/ Enrico Lupia
  • Department of Medical Sciences, University of Turin, Torino, Italy
/ Alan Maisel
  • San Diego Veterans Affairs, University California, San Diego, CA, USA
/ Frauke Hein
  • Adrenomed AG, Hennigsdorf, Germany
/ Florian Wagner
  • Anesthesiology, University Medical School, Ulm, Germany
/ Giuseppe Lippi
  • Department of Medical-Surgery Sciences and Translational Medicine, University ‘Sapienza’ Rome, Sant’Andrea Hospital, Rome, Italy
  • Laboratory of Clinical Chemistry and Haematology, Academic Hospital of Parma, Parma, Italy
Published Online: 2013-02-07 | DOI: https://doi.org/10.1515/cclm-2012-0795


Sepsis is a leading healthcare problem, accounting for the vast majority of fatal events in critically ill patients. Beyond early diagnosis and appropriate treatment, this condition requires a multifaceted approach for monitoring the severity, the potential organ failure as well as the risk of death. Monitoring of the efficacy of treatment is also a major issue in the emergency department (ED). The assessment of critically ill conditions and the prognosis of patients with sepsis is currently based on some scoring systems, which are, however, inefficient to provide definite clues about organ failure and prognosis in general. The discretionary and appropriate use of some selected biomarkers such as procalcitonin, inducible protein 10 (IP10), Group IV phospholipase A2 type II (PLA2 II), neutrophil gelatinase-associated lipocalin (NGAL), natriuretic peptides, mature adrenomedullin (ADM), mid-regional pro-adrenomedullin (MR-proADM), copeptin, thrombopoietin, Mer receptor and even red blood cell distribution width (RDW) represent thereby an appealing perspective in the diagnosis and management of patients with sepsis. Nevertheless, at the moment, it is not still clear if it is better to use a multimarkers approach or if a single, most appropriate, biomarker exists. This collective opinion paper is aimed at providing an overview about the potential clinical usefulness of some innovative biomarkers of sepsis in its diagnosis and prognosis, but also in the treatment management of the disease. This manuscript represents a synopsis of the lectures of Third Italian GREAT Network Congress, that was hold in Rome, 15–19 October 2012.

Keywords: biomarkers; emergency department; infection; procalcitonin; sepsis


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About the article

Corresponding author: Salvatore Di Somma, Emergency Medicine Department, Sant’Andrea Hospital, Via di Grottarossa 1035-1039, Rome 00189, Italy, Phone: +39 633775581, Fax: +39 0633775890

Received: 2012-11-21

Accepted: 2012-12-27

Published Online: 2013-02-07

Published in Print: 2013-06-01

Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2012-0795. Export Citation

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