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Clinical Chemistry and Laboratory Medicine (CCLM)

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Trace elements and bone health

1 / Petra Nemcikova2 / Petr Matucha1

1Institute of Endocrinology, Prague, Czech Republic

2Department of Internal Medicine, Hospital of Jindrichuv Hradec, Jindrichuv Hradec, Czech Republic

Corresponding author: Prof. MUDr. Ivana Zofková, DrSc., Institute of Endocrinology, Narodni 8, 116 94 Prague 1, Czech Republic

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 51, Issue 8, Pages 1555–1561, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2012-0868, March 2013

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The importance of nutrition factors such as calcium, vitamin D and vitamin K for the integrity of the skeleton is well known. Moreover, bone health is positively influenced by certain elements (e.g., zinc, copper, fluorine, manganese, magnesium, iron and boron). Deficiency of these elements slows down the increase of bone mass in childhood and/or in adolescence and accelerates bone loss after menopause or in old age. Deterioration of bone quality increases the risk of fractures. Monitoring of homeostasis of the trace elements together with the measurement of bone density and biochemical markers of bone metabolism should be used to identify and treat patients at risk of non-traumatic fractures. Factors determining the effectivity of supplementation include dose, duration of treatment, serum concentrations, as well as interactions among individual elements. Here, we review the effect of the most important trace elements on the skeleton and evaluate their clinical importance.

Keywords: bone density; bone quality; cadmium; copper; magnesium; manganese; zinc

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