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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

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Volume 51, Issue 9


Trp64Arg (rs4994) polymorphism of β3-adrenergic receptor gene is associated with hyperuricemia in a Chinese male population

Qiong Huang
  • Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Antiinflammatory and Immune Medicine, Ministry of Education, Hefei, P.R. China
  • Other articles by this author:
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/ Liu-Fu Zhang
  • Department of Neurology, the Third Affiliated Hospital of Anhui Medical University, First People’s Hospital in Hefei, Hefei, P.R. China
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/ Yan Cheng
  • Department of Pediatrics, the First Affiliated Hospital of Anhui Medical University, Hefei, P.R. China
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/ Ying-Chun Zhao / Li Si
  • Clinical Laboratory, the First Affiliated Hospital of Anhui Medical University, Hefei, P.R. China
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/ Ying Gao
  • Department of Endocrinology, the Third Affiliated Hospital of Anhui Medical University, First People’s Hospital in Hefei, Hefei, P.R. China
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/ Wei Wei
  • Corresponding author
  • Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Antiinflammatory and Immune Medicine, Ministry of Education, Hefei, P.R. China
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Published Online: 2013-05-13 | DOI: https://doi.org/10.1515/cclm-2012-0592


Background: β3-Adrenergic receptor (β3-AR) gene is associated with insulin resistance and may affect serum uric acid levels. Our aim was to determine the possible association between β3-AR gene Trp64Arg polymorphism (rs4994) and hyperuricemia in a Chinese male population.

Methods: A total of 410 hyperuricemic and 420 normouricemic male subjects were genotyped in this study. The genotypic and allelic frequencies were compared between the two groups. Body mass index (BMI), waist to hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), serum uric acid, urea nitrogen, creatinine, triglyceride, total cholesterol, low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C) and fasting plasma glucose (FPG) were determined.

Results: The frequencies of CC genotype and C allele for Trp64Arg polymorphism were higher in hyperuricemic group than in normouricemic group (p<0.01 and p<0.05, respectively). In both hyperuricemic and normouricemic groups, subjects with mutated C allele of Trp64Arg polymorphism showed significantly higher average uric acid levels than TT genotype carriers (p<0.01 and p<0.01, respectively). Univariate and multivariate logistic regression showed that carrier of mutated C allele of Trp64Arg polymorphism was significantly associated with hyperuricemia occurrence (p=0.003, OR=1.587, 95% CI 1.175–2.145 and p=0.003, OR=1.676, 95% CI 1.051–3.617).

Conclusions: Trp64Arg polymorphism was associated with hyperuricemia in a Chinese male population and should be an independent risk factor for hyperuricemia.

Keywords: association analysis; β3-adrenergic receptor; genetic polymorphism; hyperuricemia; serum uric acid


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About the article

Corresponding author: Professor Wei Wei, Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Hefei, Anhui 230032, P.R. China, Phone: +86 551 65161209, Fax: +86 551 65161209

Received: 2012-09-10

Accepted: 2013-04-05

Published Online: 2013-05-13

Published in Print: 2013-09-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 51, Issue 9, Pages 1755–1760, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2012-0592.

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