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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Hrsg. v. Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Band 51, Heft 9

Hefte

Autocorrelation and cross-correlation between hCGβ and PAPP-A in repeated sampling during first trimester of pregnancy

Pernille Nørgaard
  • Korrespondenzautor
  • Fetal Medicine Unit, Department of Obstetrics and Gynecology, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark
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/ Dave Wright / Susan Ball / Paul Newell / Ida Kirkegaard / Olav Bjørn Petersen
  • Fetal Medicine Unit, Department of Obstetrics and Gynecology, Aarhus University Hospital-Skejby, Aarhus, Denmark
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/ Niels Uldbjerg
  • Fetal Medicine Unit, Department of Obstetrics and Gynecology, Aarhus University Hospital-Skejby, Aarhus, Denmark
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/ Niels Tørring / Finn Stener Jørgensen
  • Fetal Medicine Unit, Department of Obstetrics and Gynecology, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark
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/ Lennart Friis-Hansen
  • Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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/ Charlotte Ekelund
  • Department of Obstetrics and Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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/ Ann Tabor
  • Center of Fetal Medicine, Department of Obstetrics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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/ Steen Sørensen
  • Department of Clinical Biochemistry, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark
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Online erschienen: 11.04.2013 | DOI: https://doi.org/10.1515/cclm-2012-0805

Abstract

Background: Theoretically, repeated sampling of free β-human chorionic gonadotropin (hCGβ) and pregnancy associated plasma protein-A (PAPP-A) in the first trimester of pregnancy might improve performance of risk assessment of trisomy 21 (T21). To assess the performance of a screening test involving repeated measures of biochemical markers, correlations between markers must be estimated. The aims of this study were to calculate the autocorrelation and cross-correlation between hCGβ and PAPP-A in the first trimester of pregnancy and to investigate the possible impact of gestational age at the first sample and time between sampling on the correlation.

Methods: A prospective study was conducted including 3891 unaffected singleton pregnancies. Two measurements of hCGβ and PAPP-A were obtained during the first trimester in each pregnancy. Correlations between the four parameters, hCGβ first, hCGβ second, PAPP-A first and PAPP-A second, were estimated and presented in terms of Pearson’s r coefficients. Furthermore, the correlation between paired samples as a function of time between samples was investigated.

Results: The study demonstrated high correlation between first and second samples of hCGβ and PAPP-A with a correlation coefficient of 0.80 and 0.79, respectively. By contrast, the correlations between hCGβ and PAPP-A were low. In addition, the study demonstrated that the correlation between paired samples of hCGβ and PAPP-A decreases with earlier gestational age at the first sample and with increasing time between samples.

Conclusions: We have developed a parameter set in terms of correlations between biochemical markers, which can be incorporated into a T21 screening algorithm based on repeated measures within the first trimester.

Keywords: combined first trimester screening; correlation; Down syndrome screening; first trimester risk assessment; free β-human chorionic gonadotropin (hCGβ); pregnancy associated plasma protein-A (PAPP-A); repeated biochemical markers; Trisomy 21 screening

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Artikelinformationen

Corresponding author: Pernille Nørgaard, MD, Fetal Medicine Unit, Department of Obstetrics and Gynecology, Hvidovre Hospital, University of Copenhagen, Copenhagen 2650, Denmark


Erhalten: 24.11.2012

Angenommen: 18.03.2013

Online erschienen: 11.04.2013

Erschienen im Druck: 01.09.2013


Quellenangabe: Clinical Chemistry and Laboratory Medicine, Band 51, Heft 9, Seiten 1781–1788, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2012-0805.

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