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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

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Volume 52, Issue 6


Dabigatran, rivaroxaban, apixaban, argatroban and fondaparinux and their effects on coagulation POC and platelet function tests

Thomas Eller
  • Institute of Laboratory Medicine, Microbiology Hygiene and Transfusion Medicine, Johannes Wesling Klinikum Minden, Minden, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jessica Busse
  • Institute for Laboratory and Transfusion Medicine, Heart and Diabetes Center, Ruhr University Bochum, Bad Oeynhausen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Marcus Dittrich / Tobias Flieder
  • Institute for Laboratory and Transfusion Medicine, Heart and Diabetes Center, Ruhr University Bochum, Bad Oeynhausen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Susanne Alban / Cornelius Knabbe
  • Institute for Laboratory and Transfusion Medicine, Heart and Diabetes Center, Ruhr University Bochum, Bad Oeynhausen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ingvild Birschmann
  • Corresponding author
  • Institute for Laboratory and Transfusion Medicine, Heart and Diabetes Center, Ruhr University Bochum, Bad Oeynhausen, Germany
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2014-01-09 | DOI: https://doi.org/10.1515/cclm-2013-0936


Background: In recent years, several selectively acting anticoagulants, including the direct thrombin inhibitors (DTI; argatroban, dabigatran) and the factor Xa inhibitors (rivaroxaban, apixaban, fondaparinux), have been developed. With their clinical application increasing, it is of interest to evaluate their interference with classical haemostaseological point-of-care tests. Additionally, the effect of the investigated anticoagulants on platelet function tests will come increasingly more into focus for monitoring not only hereditary platelet dysfunction, but also antiplatelet therapy.

Methods: Blood samples from healthy volunteers were spiked with therapeutic and supratherapeutic concentrations of the drugs listed above and investigated with regard to their effects on the following POCTs: activated clotting time (ACT), thromboelastometry with ROTEM®, PFA® and Multiplate®. Light-transmission aggregometry (LTA) was used for a platelet function assay.

Results: At supratherapeutic concentrations, ACT and ROTEM® analysis were always influenced after administration of the drugs listed above (except fondaparinux in EXTEM-CT). Therapeutic concentrations showed differential effects on these assays. LTA measurements revealed a distinct decrease in α-thrombin-induced platelet aggregation for both DTIs (therapeutic and supratherapeutic concentrations), while argatroban reduced platelet function in supratherapeutic concentrations. None of the drugs seemed to have any influence on PFA® or Multiplate®.

Conclusions: Selective thrombin and factor Xa inhibitors exhibit distinct effects on POCTs and platelet function tests. This must be considered in assessing assay results when taking medical decisions.

This article offers supplementary material which is provided at the end of the article.

Keywords: direct oral anticoagulants; direct thrombin inhibitors; platelets; point-of-care systems; preanalytics


  • 1.

    Saito H, Matsushita T, Kojima T. Historical perspective and future direction of coagulation research. J Thromb Haemost 2011;9(Suppl 1):352–63.PubMedWeb of ScienceCrossrefGoogle Scholar

  • 2.

    Soff GA. A new generation of oral direct anticoagulants. Arterioscler Thromb Vasc Biol 2012;32:569–74.Web of SciencePubMedCrossrefGoogle Scholar

  • 3.

    Ansell J, Hirsh J, Poller L, Bussey H, Jacobson A, Hylek E. The pharmacology and management of the vitamin K antagonists: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004;126(3 Suppl):204S–33S.Google Scholar

  • 4.

    Guyatt GH, Akl EA, Crowther M, Gutterman DD, Schuunemann HJ. Executive summary: antithrombotic therapy and prevention of thrombosis, 9th e. American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2012;141(2 Suppl):7S–47S.Google Scholar

  • 5.

    Okamoto S, Hijikata A, Kikumoto R, Tonomura S, Hara H, Ninomiya K, et al. Potent inhibition of thrombin by the newly synthesized arginine derivative No. 805. The importance of stereo-structure of its hydrophobic carboxamide portion. Biochem Biophys Res Commun 1981;101:440–6.Google Scholar

  • 6.

    Bauer KA. Fondaparinux sodium: a selective inhibitor of factor Xa. Am J Health Syst Pharm 2001;58(Suppl 2):S14–7.PubMedGoogle Scholar

  • 7.

    Pradaxa (dabigatran) package insert. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals; 2012.Google Scholar

  • 8.

    Mueck W, Eriksson BI, Bauer KA, Borris L, Dahl OE, Fisher WD, et al. Population pharmacokinetics and pharmacodynamics of rivaroxaban – an oral, direct factor Xa inhibitor – in patients undergoing major orthopaedic surgery. Clin Pharmacokinet 2008;47:203–16.CrossrefPubMedGoogle Scholar

  • 9.

    Raghavan N, Frost CE, Yu Z, He K, Zhang H, Humphreys WG, et al. Apixaban metabolism and pharmacokinetics after oral administration to humans. Drug Metab Dispos 2009;37:74–81.CrossrefWeb of SciencePubMedGoogle Scholar

  • 10.

    Lassen MR, Davidson BL, Gallus A, Pineo G, Ansell J, Deitchman D. The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement. J Thromb Haemost 2007;5:2368–75.PubMedCrossrefWeb of ScienceGoogle Scholar

  • 11.

    Baglin T, Hillarp A, Tripodi A, Elalamy I, Buller H, Ageno W. Measuring oral direct inhibitors (ODIs) of thrombin and factor Xa: a recommendation from the subcommittee on control of anticoagulation of the scientific and standardisation committee of the international society on thrombosis and haemostasis. J Thromb Haemost 2013;11:756–60.CrossrefGoogle Scholar

  • 12.

    Helin TA, Pakkanen A, Lassila R, Joutsi-Korhonen L. Laboratory assessment of novel oral anticoagulants: method suitability and variability between coagulation laboratories. Clin Chem 2013;59:807–14.Web of ScienceCrossrefPubMedGoogle Scholar

  • 13.

    Eby C. Novel anticoagulants and laboratory testing. Int J Lab Hematol 2013;35:262–8.CrossrefPubMedGoogle Scholar

  • 14.

    Hawes EM, Deal AM, Funk-Adcock D, Gosselin R, Jeanneret C, Cook AM, et al. Performance of coagulation tests in patients on therapeutic doses of dabigatran: a cross-sectional pharmacodynamic study based on peak and trough plasma levels. J Thromb Haemost 2013;11:1493–502.Web of SciencePubMedCrossrefGoogle Scholar

  • 15.

    Hillarp A, Baghaei F, Fagerberg Blixter I, Gustafsson KM, Stigendal L, Sten-Linder M, et al. Effects of the oral, direct factor Xa inhibitor rivaroxaban on commonly used coagulation assays. J Thromb Haemost 2011;9:133–9.PubMedCrossrefWeb of ScienceGoogle Scholar

  • 16.

    Lindahl TL, Baghaei F, Blixter IF, Gustafsson KM, Stigendal L, Sten-Linder M, et al. Effects of the oral, direct thrombin inhibitor dabigatran on five common coagulation assays. Thromb Haemost 2011;105:371–8.PubMedGoogle Scholar

  • 17.

    Kalb ML, Potura L, Scharbert G, Kozek-Langenecker SA. The effect of ex vivo anticoagulants on whole blood platelet aggregation. Platelets 2009;20:7–11.PubMedCrossrefGoogle Scholar

  • 18.

    Wong PC, Jiang X. Apixaban, a direct factor Xa inhibitor, inhibits tissue-factor induced human platelet aggregation in vitro: comparison with direct inhibitors of factor VIIa, XIa and thrombin. Thromb Haemost 2010;104:302–10.CrossrefWeb of ScienceGoogle Scholar

  • 19.

    Delavenne X, Moracchini J, Laporte S, Mismetti P, Basset T. UPLC MS/MS assay for routine quantification of dabigatran – a direct thrombin inhibitor – in human plasma. J Pharm Biomed Anal 2012;58:152–6.Web of ScienceCrossrefPubMedGoogle Scholar

  • 20.

    Alban S, Luhn S, Schiemann S. Combination of a two-step fluorescence assay and a two-step anti-Factor Xa assay for detection of heparin falsifications and protein in heparins. Anal Bioanal Chem 2011;399:681–90.Web of ScienceGoogle Scholar

  • 21.

    Kundu SK, Heilmann EJ, Sio R, Garcia C, Davidson RM, Ostgaard RA. Description of an in vitro platelet function analyzer – PFA-100. Semin Thromb Hemost 1995;21(Suppl 2):106–12.Google Scholar

  • 22.

    Michal F, Born GV. Effect of the rapid shape change of platelets on the transmission and scattering of light through plasma. Nat New Biol 1971;231:220–2.CrossrefPubMedGoogle Scholar

  • 23.

    Adcock DM, Gosselin R, Kitchen S, Dwyre DM. The effect of dabigatran on select specialty coagulation assays. Am J Clin Pathol 2013;139:102–9.PubMedWeb of ScienceCrossrefGoogle Scholar

  • 24.

    Gong IY, Kim RB. Importance of pharmacokinetic profile and variability as determinants of dose and response to dabigatran, rivaroxaban, and apixaban. Can J Cardiol 2013;29(7 Suppl): S24–33.PubMedWeb of ScienceCrossrefGoogle Scholar

  • 25.

    Neyens R, Bohm N, Cearley M, Andrews C, Chalela J. Dabigatran-associated subdural hemorrhage: using thromboelastography (TEG) to guide decision-making. J Thromb Thrombolysis 2013 May 11. [Epub ahead of print].Web of ScienceGoogle Scholar

  • 26.

    Douxfils J, Mullier F, Robert S, Chatelain C, Chatelain B, Dogne JM. Impact of dabigatran on a large panel of routine or specific coagulation assays. Laboratory recommendations for monitoring of dabigatran etexilate. Thromb Haemost 2012;107:985–97.Web of SciencePubMedCrossrefGoogle Scholar

  • 27.

    Linkins LA, Julian JA, Rischke J, Hirsh J, Weitz JI. In vitro comparison of the effect of heparin, enoxaparin and fondaparinux on tests of coagulation. Thromb Res 2002;107:241–4.PubMedCrossrefGoogle Scholar

  • 28.

    Xu Y, Wu W, Wang L, Chintala M, Plump AS, Ogletree ML, et al. Differential profiles of thrombin inhibitors (heparin, hirudin, bivalirudin, and dabigatran) in the thrombin generation assay and thromboelastography in vitro. Blood Coagul Fibrinolysis 2013;24:332–8.Web of SciencePubMedCrossrefGoogle Scholar

  • 29.

    Engstrom M, Rundgren M, Schott U. An evaluation of monitoring possibilities of argatroban using rotational thromboelastometry and activated partial thromboplastin time. Acta Anaesthesiol Scand 2010;54:86–91.CrossrefPubMedWeb of ScienceGoogle Scholar

  • 30.

    Kozek-Langenecker SA, Afshari A, Albaladejo P, Santullano CA, De Robertis E, Filipescu DC, et al. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol 2013;30:270–382.CrossrefGoogle Scholar

About the article

Corresponding author: Ingvild Birschmann, MD, PhD, Institute for Laboratory and Transfusion Medicine, Heart and Diabetes Center, Ruhr University Bochum, Georgstrasse 11, 32545 Bad Oeynhausen, Germany, Phone: +49 5731 97-3819, Fax: +49 5731 97-2307, E-mail:

aThomas Eller and Jessica Busse contributed equally to this work.

Received: 2013-10-30

Accepted: 2013-12-05

Published Online: 2014-01-09

Published in Print: 2014-06-01

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 52, Issue 6, Pages 835–844, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2013-0936.

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