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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

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1437-4331
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Volume 53, Issue 9

Issues

Myocardial interleukin-6 in the setting of left ventricular mechanical assistance: relation with outcome and C-reactive protein

Raffaele Caruso
  • Corresponding author
  • CNR-Clinical Physiology Institute, Niguarda Cà Granda Hospital, Piazza Ospedale Maggiore, 20162 Milan, Ital
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/ Chiara Caselli / Lorena Cozzi
  • CNR Institute of Clinical Physiology, Cardiothoracovascular Department, Niguarda Ca’ Granda Hospital, Milan, Italy
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/ Jonica Campolo
  • CNR Institute of Clinical Physiology, Cardiothoracovascular Department, Niguarda Ca’ Granda Hospital, Milan, Italy
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/ Federica Viglione / Marina Parolini
  • CNR Institute of Clinical Physiology, Cardiothoracovascular Department, Niguarda Ca’ Granda Hospital, Milan, Italy
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/ Sandra Nonini / Salvatore Trunfio / Andrea D’Amico / Gualtiero Pelosi / Daniela Giannessi / Paolo Marraccini
  • CNR Institute of Clinical Physiology, Cardiothoracovascular Department, Niguarda Ca’ Granda Hospital, Milan, Italy
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/ Maria Frigerio / Oberdan Parodi
  • CNR Institute of Clinical Physiology, Cardiothoracovascular Department, Niguarda Ca’ Granda Hospital, Milan, Italy
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Published Online: 2014-11-20 | DOI: https://doi.org/10.1515/cclm-2014-0633

Abstract

Background: In left ventricular assist device (LVAD) recipients, plasma levels of interleukin (IL)-6 are associated with Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profiles, reflecting post-operative risk. However, it is not clear how the cardiac level of IL-6, detectable on the tissue samples at the time of implantation, can contribute to predict the post-operative outcome.

Methods: In 40 LVAD recipients, blood and myocardial samples from LV-apex were collected at the time of implantation to assess plasma and cardiac IL-6 levels. Serum C-reactive protein (CRP) levels were considered as inflammatory variable routinely used in LVAD-based therapy.

Results: Cardiac IL-6 levels did not correlate with either plasma IL-6 levels (R=0.296, p=0.063) and tissue IL-6 mRNA expression (R=–0.013, p=0.954). Contrary to what happened for the plasma IL-6 and CRP, no differences were observed in cardiac IL-6 levels with respect to INTERMACS profiles (p=0.090). Furthermore, cardiac IL-6 concentrations, unlike IL-6 and CRP circulating levels, were not correlated with the length of intensive care unit stay and hospitalization.

Conclusions: Cardiac IL-6 levels do not contribute to improve risk profile of LVAD recipients in relation to clinical inpatient post-implantation. Instead, plasma IL-6 and serum CRP concentrations are more effective in predicting the severity of the clinical course in the early phase of LVAD therapy.

Keywords: C-reactive protein; interleukin-6; mechanical circulatory support; myocardium

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About the article

Corresponding author: Dr. Raffaele Caruso, CNR-Clinical Physiology Institute, Niguarda Cà Granda Hospital, Piazza Ospedale Maggiore, 20162 Milan, Italy, Phone: +39 02 6473407, Fax: +39 02 66116990, E-mail:


Received: 2014-06-16

Accepted: 2014-10-13

Published Online: 2014-11-20

Published in Print: 2015-08-01


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 53, Issue 9, Pages 1359–1366, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2014-0633.

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