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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Volume 53, Issue 9

Issues

Exploration of the pre-analytical stability of β-lactam antibiotics in plasma and blood – implications for therapeutic drug monitoring and pharmacokinetic studies

Mieke Carlier
  • Corresponding author
  • Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium
  • Department of Critical Care Medicine, Ghent University, Ghent, Belgium
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jan J. De Waele / Alain G. Verstraete
  • Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium
  • Department of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Veronique Stove
  • Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium
  • Department of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2014-11-06 | DOI: https://doi.org/10.1515/cclm-2014-0833

References

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    Vincent J-L, Rello J, Marshall J, Silva E, Anzueto A, Martin CD, et al. International study of the prevalence and outcomes of infection in intensive care units. J Am Med Assoc 2009;302:2323–9.Google Scholar

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    Leibovici L, Shraga I, Drucker M, Konigsberger H, Samra Z, Pitlik SD. The benefit of appropriate empirical antibiotic treatment in patients with bloodstream infection. J Intern Med 1998;244:379–86.Google Scholar

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    Roberts J, Paul S, Akova M, Bassetti M, De Waele J, Dimopoulos G, et al. DALI: defining antibiotic levels in intensive care unit patients: are current beta-lactam antibiotic doses sufficient for critically ill patients. Clin Infect Dis 2014;58:1072–83.Web of ScienceCrossrefPubMedGoogle Scholar

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    Roberts J, Lipman J. Pharmacokinetic issues for antibiotics in the critically ill patient. Crit Care Med 2009;37:840–51.Google Scholar

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    Roberts JA, Ulldemolins M, Roberts MS, McWhinney B, Ungerer J, Paterson DL, et al. Therapeutic drug monitoring of beta-lactams in critically ill patients: proof of concept. Int J Antimicrob Agents 2010;36:332–9.CrossrefGoogle Scholar

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    De Waele JJ, Carrette S, Carlier M, Stove V, Boelens J, Claeys G, et al. Therapeutic drug monitoring-based dose optimisation of piperacillin and meropenem: a randomised controlled trial. Intens Care Med 2014;40:380–7.Web of ScienceCrossrefGoogle Scholar

  • 7.

    Verdier MC, Tribut O, Tattevin P, Le Tulzo Y, Michelet C, Bentue-Ferrer D. Simultaneous determination of 12 beta-lactam antibiotics in human plasma by high-performance liquid chromatography with UV detection: application to therapeutic drug monitoring. Antimicrob Agents Chemother 2011;55:4873–9.Google Scholar

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    Beumier M, Casu GS, Hites M, Seyler L, Cotton F, Vincent J-L, et al. Beta-lactam antibiotic concentrations during continuous renal replacement therapy. Crit Care 2014;18:R105.CrossrefWeb of ScienceGoogle Scholar

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    Doh K, Woo H, Hur J, Yim H, Kim J, Chae H, et al. Population pharmacokinetics of meropenem in burn patients. J Antimicrob Chemother 2010;65:2428–35.CrossrefGoogle Scholar

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    Forgue ST, Pittman KA, Barbhaiya RH. High-performance liquid chromatographic analysis of a novel carbapenem antibiotic in human plasma and urine. J Chromatogr 1987;414:343–53.Google Scholar

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    Carlier M, Stove V, Roberts JA, Van de Velde E, De Waele JJ, Verstraete AG. Quantification of seven β-lactam antibiotics and two β-lactamase inhibitors in human plasma using a validated UPLC-MS/MS method. Int J Antimicrob Agents 2012;40:416–22.CrossrefWeb of ScienceGoogle Scholar

About the article

Corresponding author: Mieke Carlier, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, De Pintelaan 185, Building 2P8, 9000, Ghent, Belgium; and Department of Critical Care Medicine, Ghent University, Ghent, Belgium, Phone: +32 9 3326733, Fax: +32 9 3324985, E-mail:


Received: 2014-08-19

Accepted: 2014-10-13

Published Online: 2014-11-06

Published in Print: 2015-08-01


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 53, Issue 9, Pages e227–e230, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2014-0833.

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