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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 53, Issue 9


Faecal haemoglobin concentrations do vary across geography as well as with age and sex: ramifications for colorectal cancer screening

Callum G. Fraser
  • Corresponding author
  • Centre for Research into Cancer Prevention and Screening, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Josep M. Auge
  • Biochemistry and Molecular Genetics Department, Hospital Clinic, Colorectal Cancer Screening Program, Barcelona, Catalonia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ on behalf of the PROCOLON Group
Published Online: 2014-12-29 | DOI: https://doi.org/10.1515/cclm-2014-1172


  • 1.

    Carroll MR, Seaman HE, Halloran SP. Tests and investigations for colorectal cancer screening. Clin Biochem 2014;47:921–39.Web of ScienceCrossrefGoogle Scholar

  • 2.

    Allison JE, Fraser CG, Halloran SP, Young GP. Population screening for colorectal cancer means getting FIT: the past, present, and future of colorectal cancer screening using FIT. Gut Liver 2014;8:117–30.CrossrefGoogle Scholar

  • 3.

    Chen LS, Yen AM, Chiu SY, Liao CS, Chen HH. Baseline faecal occult blood concentration as a predictor of incident colorectal neoplasia: longitudinal follow-up of a Taiwanese population-based colorectal cancer screening cohort. Lancet Oncol 2011;12:551–8.CrossrefWeb of ScienceGoogle Scholar

  • 4.

    Chen LS, Yen AM, Fraser CG, Chiu SY, Fann JC, Wang PE, et al. Impact of faecal haemoglobin concentration on colorectal cancer mortality and all-cause death. Br Med J Open 2013;3:e003740.Google Scholar

  • 5.

    McDonald PJ, Strachan JA, Digby J, Steele RJ, Fraser CG. Faecal haemoglobin concentrations by gender and age: implications for population-based screening for colorectal cancer. Clin Chem Lab Med 2012;50:935–40.Web of ScienceGoogle Scholar

  • 6.

    Auge JM, Pellise M, Escudero JM, Hernandez C, Andreu M, Grau J, et al. Risk stratification for advanced colorectal neoplasia according to fecal hemoglobin concentration in a colorectal cancer screening program. Gastroenterology 2014;14:628–36.CrossrefWeb of ScienceGoogle Scholar

  • 7.

    Fraser CG, Rubeca T, Rapi S, Chen LS, Chen HH. Faecal haemoglobin concentrations vary with sex and age, but data are not transferable across geography for colorectal cancer screening. Clin Chem Lab Med 2014;52:1211–6.Web of ScienceGoogle Scholar

  • 8.

    Chiang TH, Chuang SL, Chen SL, Chiu HM, Yen AM, Chiu SY et al. Difference in performance of fecal immunochemical tests with the same hemoglobin cutoff concentration in a nationwide colorectal cancer screening program. Gastroenterology 2014;147:1317–26.Web of ScienceCrossrefGoogle Scholar

  • 9.

    Fraser CG, Allison JE, Halloran SP, Young GP; Expert Working Group on Fecal Immunochemical Tests for Hemoglobin, Colorectal Cancer Screening Committee, World Endoscopy Organization. A proposal to standardize reporting units for fecal immunochemical tests for hemoglobin. J Natl Cancer Inst 2012;104:810–4.CrossrefGoogle Scholar

About the article

Corresponding author: Professor Callum G. Fraser, Centre for Research into Cancer Prevention and Screening, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK, Phone: +44 1382553799, Fax: +44 1382383615, E-mail:

Received: 2014-11-28

Accepted: 2014-11-30

Published Online: 2014-12-29

Published in Print: 2015-08-01

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 53, Issue 9, Pages e235–e237, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2014-1172.

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