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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

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Volume 54, Issue 6


Free light chain testing for the diagnosis, monitoring and prognostication of AL amyloidosis

Peter Mollee
  • Corresponding author
  • Haematology Department, Princess Alexandra Hospital, Ipswich Rd, Woolloongabba, QLD 4102, Australia
  • Amyloidosis Centre, Princess Alexandra Hospital, Brisban, Australia; and School of Medicine, University of Queensland, Brisbane, Australia
  • School of Medicine, University of Queensland, Brisbane, Australia
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Giampaolo Merlini
  • Amyloidosis Research and Treatment Center, Foundation IRCCS Policlinico San Matteo
  • Department of Molecular Medicine, University of Pavia, Pavia, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2016-01-14 | DOI: https://doi.org/10.1515/cclm-2015-0938


The disease causing agent in systemic AL amyloidosis is a monoclonal immunoglobulin free light chain, or fragments thereof, circulating in the blood. It is not surprising, therefore, that measurement of serum free light chains plays a central role in the management of this disorder. In this paper, we review the utility of the serum free light chain assay in the investigation, prognostication and monitoring of AL amyloidosis. Data on the two currently available commercial assays is compared and some practical applications of the assay’s use are presented. While there are limitations, it is clear that the availability of the free light chain assay in the laboratory is a major advance and plays an essential role in the management of patients with AL amyloidosis.

Keywords: AL amyloidosis; free light chains; monitoring


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About the article

Corresponding author: Peter Mollee, Haematology Department, Princess Alexandra Hospital, Ipswich Rd, Woolloongabba, QLD 4102, Australia; Amyloidosis Centre, Princess Alexandra Hospital, Brisban, Australia; and School of Medicine, University of Queensland, Brisbane, Australia; and School of Medicine, University of Queensland, Brisbane, Australia

Received: 2015-09-28

Accepted: 2015-12-14

Published Online: 2016-01-14

Published in Print: 2016-06-01

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 54, Issue 6, Pages 921–927, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2015-0938.

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