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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2017: 3.556

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 55, Issue 11


Can we still trust hemoglobin A1c in all situations?

Elisa Danese / Martina Montagnana / Gian Luca Salvagno / Giuseppe LippiORCID iD: http://orcid.org/0000-0001-9523-9054
Published Online: 2017-04-13 | DOI: https://doi.org/10.1515/cclm-2017-0114


  • 1.

    American Diabetes Association. Statistics About Diabetes. Available at: http://www.diabetes.org/diabetes-basics/statistics/. Accessed 8 Feb 2017.

  • 2.

    Centers for Disease Control and Prevention. National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States, 2014. Atlanta, GA: US Department of Health and Human Services; 2014.Google Scholar

  • 3.

    American Diabetes Association. Classification and diagnosis of diabetes. Diabetes Care 2016;39(Suppl 1):S13–22.PubMedGoogle Scholar

  • 4.

    Lippi G, Targher G. Glycated hemoglobin (HbA1c): old dogmas, a new perspective? Clin Chem Lab Med 2010;48:609–14.Web of ScienceGoogle Scholar

  • 5.

    Lippi G, Targher G. A laboratory standpoint on the role of hemoglobin A1c for the diagnosis of diabetes in childhood: more doubts than certainties? Pediatr Diabetes 2011;12:183–6.CrossrefWeb of ScienceGoogle Scholar

  • 6.

    Salinas M, López-Garrigós M, Flores E, Leiva-Salinas M, Lugo J, Pomares FJ, et al. Automatic laboratory-based strategy to improve the diagnosis of type 2 diabetes in primary care. Biochem Med (Zagreb) 2016;26:121–8.Google Scholar

  • 7.

    Lacy ME, Wellenius GA, Sumner AE, Correa A, Carnethon MR, Liem RI, et al. Association of sickle cell trait with hemoglobin A1c in African Americans. J Am Med Assoc 2017;317:507–15.CrossrefGoogle Scholar

  • 8.

    Rohlfing C, Hanson S, Weykamp C, Siebelder C, Higgins T, Molinaro R, et al. Effects of hemoglobin C, D, E and S traits on measurements of hemoglobin A1c by twelve methods. Clin Chim Acta 2016;455:80–3.CrossrefGoogle Scholar

  • 9.

    You-Qiong L, Hui-Ping H, Zhi-Zhong C, Lin Z, Liang L, Gui-Fang Q, et al. Comparison of capillary electrophoresis and high performance liquid chromatography for detection and quantification of hemoglobin New York. Clin Chem Lab Med 2016;54:91–5.Web of SciencePubMedGoogle Scholar

  • 10.

    Ji L, Yu J, Zhou Y, Xia Y, Xu A, Li W, et al. Erroneous HbA1c measurements in the presence of β-thalassemia and common Chinese hemoglobin variants. Clin Chem Lab Med 2015;53:1451–8.PubMedGoogle Scholar

  • 11.

    Lippi G, Plebani M. Capillary electrophoresis for the screening and diagnosis of inherited hemoglobin disorders. Ready for prime time? Clin Chem Lab Med 2016;54:5–6.Web of SciencePubMedGoogle Scholar

  • 12.

    Yun YM, Ji M, Ko DH, Chun S, Kwon GC, Lee K, et al. Hb variants in Korea: effect on HbA1c using five routine methods. Clin Chem Lab Med 2017. doi: 10.1515/cclm-2016-0865. [Epub ahead of print].PubMedGoogle Scholar

  • 13.

    Kabytaev K, Connolly S, Rohlfing CL, Sacks DB, Stoyanov AV, Little RR. Higher degree of glycation of hemoglobin S compared to hemoglobin A measured by mass spectrometry: potential impact on HbA1c testing. Clin Chim Acta 2016;458:40–3.CrossrefPubMedGoogle Scholar

  • 14.

    Lee BS, Jayathilaka GD, Huang JS, Vida LN, Honig GR, Gupta S. Analyses of in vitro nonenzymatic glycation of normal and variant hemoglobins by MALDI-TOF mass spectrometry. J Biomol Tech 2011;22:90–4.PubMedGoogle Scholar

  • 15.

    Lipska KJ, Krumholz HM. Is hemoglobin A1c the right outcome for studies of diabetes? J Am Med Assoc 2017;317:1017–8.CrossrefGoogle Scholar

  • 16.

    Rodríguez-Gutiérrez R, Montori VM. Glycemic control for patients with type 2 diabetes mellitus: our evolving faith in the face of evidence. Circ Cardiovasc Qual Outcomes 2016;9:504–12.Web of SciencePubMedCrossrefGoogle Scholar

  • 17.

    Sacks DB, John WG. Interpretation of hemoglobin A1c values. J Am Med Assoc 2014;311:2271–2.CrossrefGoogle Scholar

About the article

Corresponding author: Prof. Martina Montagnana, Section of Clinical Biochemistry, University of Verona, Verona, Italy

Received: 2017-02-08

Accepted: 2017-03-15

Published Online: 2017-04-13

Published in Print: 2017-10-26

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 55, Issue 11, Pages e241–e242, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2017-0114.

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