Baca B, Beart RW, Jr., Etzioni DA. Surveillance after colorectal cancer resection: a systematic review. Dis Colon Rectum 2011;54:1036–48.Google Scholar
Hine KR, Dykes PW. Serum CEA testing in the post-operative surveillance of colorectal carcinoma. Br J Cancer 1984;49:689–93.Google Scholar
McCall JL, Black RB, Rich CA, Harvey JR, Baker RA, Watts JM, et al. The value of serum carcinoembryonic antigen in predicting recurrent disease following curative resection of colorectal cancer. Dis Colon Rectum 1994;37:875–81.Google Scholar
Park IJ, Choi GS, Lim KH, Kang BM, Jun SH. Serum carcinoembryonic antigen monitoring after curative resection for colorectal cancer: clinical significance of the preoperative level. Ann Surg Oncol 2009;16:3087–93.Google Scholar
Zeng Z, Cohen AM, Urmacher C. Usefulness of carcinoembryonic antigen monitoring despite normal preoperative values in node-positive colon cancer patients. Dis Colon Rectum 1993;36:1063–8.Google Scholar
Meyerhardt JA, Mangu PB, Flynn PJ, Korde L, Loprinzi CL, Minsky BD, et al. Follow-up care, surveillance protocol, and secondary prevention measures for survivors of colorectal cancer: American Society of Clinical Oncology clinical practice guideline endorsement. J Clin Oncol 2013;31:4465–70.Google Scholar
Labianca R, Nordlinger B, Beretta GD, Mosconi S, Mandalà M, Cervantes A, et al. Early colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2013;24(Suppl 6):vi64–72.Google Scholar
Desch CE, Benson AB, 3rd, Somerfield MR, Flynn PJ, Krause C, Loprinzi CL, et al. Colorectal cancer surveillance: 2005 update of an American Society of Clinical Oncology practice guideline. J Clin Oncol 2005;23:8512–9.Google Scholar
Hara M, Kanemitsu Y, Hirai T, Komori K, Kato T. Negative serum carcinoembryonic antigen has insufficient accuracy for excluding recurrence from patients with Dukes C colorectal cancer: analysis with likelihood ratio and posttest probability in a follow-up study. Dis Colon Rectum 2008;51:1675–80.Google Scholar
Meyerhardt JA, Mayer RJ. Follow-up strategies after curative resection of colorectal cancer. Semin Oncol 2003;30:349–60.Google Scholar
Verberne CJ, Zhan Z, van den Heuvel E, Grossmann I, Doornbos PM, Havenga K, et al. Intensified follow-up in colorectal cancer patients using frequent Carcino-Embryonic Antigen (CEA) measurements and CEA-triggered imaging: Results of the randomized “CEAwatch” trial. Eur J Surg Oncol 2015;41:1188–96.Google Scholar
Verberne CJ, Jong de H, Grossmann I, de Bock GH, Wiggers T, Kema I, et al. Tumor markers in finding recurrent disease in colorectal cancer. J Mol Biochem 2013;2:56–68.Google Scholar
Alvarez JA, Marin J, Jover JM, Fernández R, Fradejas J, Moreno M. Sensitivity of monoclonal antibodies to carcinoembryonic antigen, tissue polypeptide antigen, alpha-fetoprotein, carbohydrate antigen 50, and carbohydrate antigen 19-9 in the diagnosis of colorectal adenocarcinoma. Dis Colon Rectum 1995;38:535–42.Google Scholar
Fernandes LC, Kim SB, Matos D. Cytokeratins and carcinoembryonic antigen in diagnosis, staging and prognosis of colorectal adenocarcinoma. World J Gastroenterol 2005;11:645–8.Google Scholar
Plebani M, De Paoli M, Basso D, Roveroni G, Giacomini A, Galeotti F, et al. Serum tumor markers in colorectal cancer staging, grading, and follow-up. J Surg Oncol 1996;62:239–44.Google Scholar
Fernandes LC, Kim SB, Saad SS, Matos D. Value of carcinoembryonic antigen and cytokeratins for the detection of recurrent disease following curative resection of colorectal cancer. World J Gastroenterol 2006;12:3891–4.Google Scholar
Nicolini A, Ferrari P, Duffy MJ, Antonelli A, Rossi G, Metelli MR, et al. Intensive risk-adjusted follow-up with the CEA, TPA, CA19.9, and CA72.4 tumor marker panel and abdominal ultrasonography to diagnose operable colorectal cancer recurrences: effect on survival. Arch Surg 2010;145:1177–83.Google Scholar
Zhan Z, van den Heuvel ER, Doornbos PM, Burger H, Verberne CJ, Wiggers T, et al. Strengths and weaknesses of a stepped wedge cluster randomized design: its application in a colorectal cancer follow-up study. J Clin Epidemiol 2014;67:454–61.Google Scholar
Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 1982;143:29–36.Google Scholar
Lorenzi M, Vindigni C, Minacci C, Tripodi SA, Iroatulam A, Petrioli R, et al. Histopathological and prognostic evaluation of immunohistochemical findings in colorectal cancer. Int J Biol Markers 1997;12:68–74.Google Scholar
Bystrom P, Berglund A, Nygren P, Wernroth L, Johansson B, Larsson A, et al. Evaluation of predictive markers for patients with advanced colorectal cancer. Acta Oncol 2012;51:849–59.Google Scholar
Holdenrieder S, Stieber P, Liska V, Treska V, Topolcan O, Dreslerova J, et al. Cytokeratin serum biomarkers in patients with colorectal cancer. Anticancer Res 2012;32:1971–6.Google Scholar
Treska V, Topolcan O, Stanislav K, Liska V, Holubec L. Preoperative tumor markers as prognostic factors of colorectal liver metastases. Hepatogastroenterology 2009;56:317–20.Google Scholar
About the article
Published Online: 2016-08-13
Published in Print: 2017-02-01
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission. Statistical analysis was carried out by Z.Z.
Research funding: For this study, a research grant was received from the Dutch Society for Clinical Chemistry and Laboratory Medicine. The encompassing study “CEAwatch” was sponsored by ZonMw, The Netherlands Organization for Health Research and Development.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.