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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

SCImago Journal Rank (SJR) 2017: 1.114
Source Normalized Impact per Paper (SNIP) 2017: 1.188

Online
ISSN
1437-4331
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Volume 55, Issue 3

Issues

How to define reference intervals to rule in healthy individuals for clinical trials?

Wendy P.J. den Elzen
  • Corresponding author
  • Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Joop van Gerven / Paul W. Schenk
  • Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands
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/ Anna Uit Den Boogaard / Ria Kroon / Erica Klaassen / Bart E.P.B. Ballieux
  • Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands
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  • De Gruyter OnlineGoogle Scholar
/ Christa M. Cobbaert
  • Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Published Online: 2016-08-13 | DOI: https://doi.org/10.1515/cclm-2016-0307

References

  • 1.

    Koerbin G, Sikaris KA, Jones GR, Ryan J, Reed M, Tate J, et al. Evidence-based approach to harmonised reference intervals. Clin Chim Acta 2014;432:99–107.Google Scholar

  • 2.

    Horowitz GL, Altaie S, Boyd JC, Ceriotti F, Garg U, Horn P, et al. Defining, establishing, and verifying reference intervals in the clinical laboratory; approved guideline – 3rd ed., volume 28, number 30 (CLSI document C28-A3c).Google Scholar

  • 3.

    Ozarda Y, Ichihara K, Barth JH, Klee G; Committee on Reference Intervals and Decision Limits (C-RIDL), International Federation for Clinical Chemistry and Laboratory Medicine. Protocol and standard operating procedures for common use in a worldwide multicenter study on reference values (IFCC C-RIDL). Clin Chem Lab Med 2013;51:1027–40.Google Scholar

  • 4.

    Cobbaert C, Weykamp C, Franck P, de Jonge R, Kuypers A, Steigstra H, et al. Systematic monitoring of standardization and harmonization status with commutable EQA-samples – Five year experience from the Netherlands. Clin Chim Acta 2012;414:234–40.Google Scholar

  • 5.

    Horn PS, Pesce AJ. Reference intervals: an update. Clin Chim Acta 2003;334:5–23.Google Scholar

About the article

Corresponding author: Wendy P.J. den Elzen, PhD, Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Postal zone E2-P, 2300 RC, Leiden, The Netherlands, Phone: +31 71 526 2278


Received: 2016-04-13

Accepted: 2016-07-20

Published Online: 2016-08-13

Published in Print: 2017-03-01


Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission. All authors confirmed they have contributed to the intellectual content of this paper and have met the following three requirements: (a) significant contributions to the conception and design, acquisition of data, or analysis and interpretation of data; (b) drafting or revising the article for intellectual content; and (c) final approval of the published article.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 55, Issue 3, Pages e59–e61, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2016-0307.

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