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Licensed Unlicensed Requires Authentication Published by De Gruyter June 25, 2016

Serum uric acid levels and risk of prehypertension: a meta-analysis

  • Menglin Jiang , Dandan Gong and Yu Fan EMAIL logo

Abstract

Elevated serum uric acid (SUA) levels may increase the risk of prehypertension. However, the findings from these studies remain conflicting. The objective of this study was to determine the relationship between SUA levels and risk of prehypertension by conducting a meta-analysis. We conducted a comprehensive literature search of PubMed, Embase, China National Knowledge Infrastructure, VIP, and the Wangfang database without language restrictions through May 2015. Observational studies assessing the relationship between SUA levels and prevalence of prehypertension were included. Pooled adjust odds ratio (OR) and corresponding 95% confidence intervals (CI) of prehypertension were calculated for the highest vs. lowest SUA levels. Prehypertension was defined as systolic blood pressure (BP) ranging from 120 to 139 mmHg or diastolic BP ranging from 80 to 89 mmHg. Eight cross-sectional studies with a total of 21,832 prehypertensive individuals were included. Meta-analysis showed that elevated SUA levels were associated with increased risk of prehypertension (OR: 1.84; 95% CI: 1.42–2.38) comparing the highest vs. lowest level of SUA levels. Subgroup analyses showed that elevated SUA levels significantly increased the risk of prehypertension among men (OR: 1.60; 95% CI: 1.12–2.21) and women (OR: 1.59; 95% CI: 1.17–2.16). Elevated SUA levels are positively associated with the risk of prehypertension in the general population. However, more well-designed longitudinal studies are needed before a definitive conclusion can be drawn due to the cross-sectional studies included are susceptible to bias.


Corresponding author: Prof. Yu Fan, Institute of Molecular Biology and Translational Medicine, The Affiliated People’s Hospital, Jiangsu University, No. 8 Dianli Road, Zhenjiang 212002, Jiangsu, P.R. China, Phone: +86-511-88915233, Fax: +86-511-85234387

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This work was supported by Jiangsu Provincial Key&D Special Fund (BE2015666).

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2016-4-21
Accepted: 2016-5-21
Published Online: 2016-6-25
Published in Print: 2017-3-1

©2017 Walter de Gruyter GmbH, Berlin/Boston

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