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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

Online
ISSN
1437-4331
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Volume 55, Issue 7

Issues

IgD-λ myeloma with extensive free light-chain excretion: a diagnostic pitfall in the identification of monoclonal gammopathies

Christoph Robier
  • Corresponding author
  • Institute of Medical and Chemical Laboratory Diagnostics, Hospital of the Brothers of St. John of God, Graz, Austria
  • Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
  • Email
  • Other articles by this author:
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/ Maria Piribauer
  • Department of Internal Medicine, Hospital of the Brothers of St. John of God, St. Veit/Glan, Austria
  • Other articles by this author:
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/ Christine Beham-Schmid / Kristina Aubell / Manfred Neubauer
  • Institute of Medical and Chemical Laboratory Diagnostics, Hospital of the Brothers of St. John of God, Graz, Austria
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Published Online: 2016-11-07 | DOI: https://doi.org/10.1515/cclm-2016-0653

References

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    Zagouri F, Kastritis E, Symeonidis AS, Giannakoulas N, Katodritou E, Delimpasi S, et al. Immunoglobulin D myeloma: clinical features and outcome in the era of novel agents. Eur J Haematol 2013;92:308–12.Web of ScienceGoogle Scholar

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    Kim MK, Suh C, Lee DH, Min C-K, Kim SJ, Kim K, et al. Immunoglobulin D multiple myeloma: response to therapy, survival, and prognostic factors in 75 patients. Ann Oncol 2011;22:411–6.Web of ScienceGoogle Scholar

  • 3.

    Jancelewicz Z, Takatsuki K, Sugai S, Pruzanski W. IgD multiple myeloma. Review of 133 cases. Arch Int Med 1975;135:87–93.Google Scholar

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    Sinclair D. IgD myeloma: clinical, biological and laboratory features. Clin Lab 2002;48:617–22.Google Scholar

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    Benchekroun L, Ouzzif Z, Bouabdillah M, Jaouhar N, Aoufir F, Aoufi F, et al. Multiple myeloma with D immunoglobulin. Ann Biol Clin (Paris) 2011;69:581–7.Google Scholar

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    Bladè J, Lust LA, Kyle RA. Immunoglobulin D multiple myeloma: presenting features, response to therapy, and survival in a series of 53 cases. J Clin Oncol 1994;12:2398–404.CrossrefGoogle Scholar

  • 7.

    Galeazzi M, Frezzotti A, Paladini C, Leoni P, Tocchini M. A case of monoclonal gammopathy of undetermined significance (MGUS): type IgD-lambda. Clin Chem Lab Med 2013;51:e123–5.Web of ScienceGoogle Scholar

  • 8.

    Caldini A, Nozzoli C, Terreni A, Staderini M, Berardi M, Biaglioli T, et al. New patterns of relapse in multiple myeloma: a case of “light chain escape” in which FLC predicted relapse earlier than urine and serum immunofixation. Clin Chem Lab Med 2016;54:991–5.Web of ScienceGoogle Scholar

  • 9.

    Djidjik R, Lounici Y, Chergeulaine K, Berkouk Y, Mouhoub S, Chaib S, et al. IgD multiple myeloma: clinical, biological features and prognostic value of the serum free light chain assay. Pathol Biol (Paris) 2015;63:210–4.CrossrefWeb of ScienceGoogle Scholar

  • 10.

    Brioli A, Giles H, Pawlyn C, Campbell JP, Kaiser MF, Melchor L, et al. Serum free immunoglobulin light chain evaluation as a marker of impact from intraclonal heterogeneity on myeloma outcome. Blood 2014;123:3414–9.Web of ScienceGoogle Scholar

About the article

Corresponding author: Christoph Robier, MD, Institute of Medical and Chemical Laboratory Diagnostics, Hospital of the Brothers of St. John of God, Graz, Bergstrasse 27, 8020 Graz, Austria, Phone: +43 316 5989 26671


Received: 2016-07-21

Accepted: 2016-10-10

Published Online: 2016-11-07

Published in Print: 2017-06-27


Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 55, Issue 7, Pages e137–e139, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2016-0653.

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