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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

SCImago Journal Rank (SJR) 2017: 1.114
Source Normalized Impact per Paper (SNIP) 2017: 1.188

Online
ISSN
1437-4331
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Volume 56, Issue 2

Issues

Individual values of antineutrophil cytoplasmic antibodies do not correspond between antigen-specific assays

Niels Rasmussen / Jan Damoiseaux
  • Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Elena Csernok
  • Department of Rheumatology and Immunology, Medius Kliniken Kirchheim/Teck, University Tübingen, Tübingen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Niels H.H. Heegaard / Bernhard Hellmich
  • Department of Rheumatology and Immunology, Medius Kliniken Kirchheim/Teck, University Tübingen, Tübingen, Germany
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  • De Gruyter OnlineGoogle Scholar
/ Pieter van Paassen
  • Department of Internal Medicine, Section Nephrology and Immunology, Maastricht University Medical Center, Maastricht, The Netherlands
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/ Bo Baslund / Pieter Vermeersch
  • Clinical Department of Laboratory Medicine, University Hospitals Leuven, 3000 Leuven, Belgium
  • Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
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/ Daniel Blockmans
  • Clinical Department of General Internal Medicine, Research Department of Microbiology and Immunology, Laboratory of Clinical Infectious and Inflammatory Disorders, University Hospitals Leuven, Leuven, Belgium
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/ Jan-Willem Cohen Tervaert / Xavier Bossuyt
  • Corresponding author
  • Department of Laboratory Medicine, University Hospitals Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium, Phone: +32 16 347009, Fax: +32 16 34 79 31
  • Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium
  • Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium
  • Email
  • Other articles by this author:
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Published Online: 2017-07-29 | DOI: https://doi.org/10.1515/cclm-2017-0362

References

  • 1.

    Damoiseaux J, Csernok E, Rasmussen N, Moosig F, van Paassen P, Baslund B, et al. Detection of antineutrophil cytoplasmic antibodies (ANCAs): a multicentre European Vasculitis Study Group (EUVAS) evaluation of the value of indirect immunofluorescence (IIF) versus antigen-specific immunoassays. Ann Rheum Dis 2016;76:647–53.Web of ScienceGoogle Scholar

  • 2.

    Bossuyt X, Rasmussen N, van Paassen P, Hellmich B, Baslund B, Vermeersch P, et al. Anti-neutrophil cytoplasmic antibodies (ANCA) by immuno-assay: a multicenter study to improve clinical interpretation of PR3- and MPO-ANCA. Rheumatology (Oxford) 2017. doi: 10.1093/rheumatology/kex170. [Epub ahead of print].Google Scholar

  • 3.

    Vermeersch P, Blockmans D, Bossuyt X. Use of likelihood ratios can improve the clinical usefulness of enzyme immunoassays for the diagnosis of small-vessel vasculitis. Clin Chem 2009;55:1886–8.CrossrefWeb of ScienceGoogle Scholar

  • 4.

    Kemna MJ, van Paassen P, Damoiseaux JGMC, Cohen Tervaert JW. Maintaining remission in patients with granulomatosis with polyangiitis or microscopic polyangiitis: the role of ANCA. Expert Opin Orphan Drugs 2017;5:207–18Web of ScienceGoogle Scholar

  • 5.

    Monogioudi E, Hutu DP, Martos G, Sheldon J, Schimmel H, Meroni PL, et al. Development of a certified reference material for myeloperoxidase-anti-neutrophil cytoplasmic autoantibodies (MPO-ANCA). Clin Chim Acta 2017;467:48–50.Web of SciencePubMedCrossrefGoogle Scholar

About the article

Received: 2017-05-05

Accepted: 2017-06-27

Published Online: 2017-07-29

Published in Print: 2018-01-26


Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: Bio-Rad Laboratories Inc., Euro-Diagnostica AB, Euroimmun, Medipan/Generic assays GmbH, INOVA Diagnostics, Orgentec, and Thermo Fisher Scientific provided reagents to perform the study.

Employment or leadership: X.B. has received speaker fees from Thermo Fisher and INOVA, has been a consultant for INOVA and has received a research grant from Thermo Fisher. E.C. has received lecture fees from Bio-Rad Lab, Inova Diagnostics and Thermo Fisher.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 56, Issue 2, Pages e39–e42, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2017-0362.

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