Verily. Project Baseline. 2018. https://www.projectbaseline.com/. Accessed: 2 January 2019.
National Institutes of Health. All of Us Research Program. https://allofus.nih.gov/. Accessed: 3 Jan 2019.
Lake Nona Institute. About Lake Nona Life Project. 2018. http://www.liveworkparticipate.com/about-lnlp/. Accessed: 2 Jan 2019.
Prince ND, Magis AT, Earls JC, Glusman G, Levy R, Lausted C, et al. A wellness study of 108 individuals using personal, dense, dynamic data clouds. Nat Biotechnol 2017;35:747–56.CrossrefPubMedWeb of ScienceGoogle Scholar
Providence St Joseph’s Health. P4 medicine. http://future.psjhealth.org/scientific-wellness/p4-medicine. Accessed: 2 Jan 2019.
Institute for Systems Biology. P4 medicine. https://systemsbiology.org/research/p4-medicine/. Accessed 2 Jan 2019.
Barter PJ, Caulfield M, Eriksson M, Grundy SM, Kastelein JJ, Komajda M, et al. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med 2007;357:2109–22.PubMedCrossrefWeb of ScienceGoogle Scholar
Hickner J, Thompson PJ, Wilkinson T, Epner P, Sheehan M, Pollock AM, et al. Primary care physicians’ challenges in ordering clinical laboratory tests and interpreting results. J Am Board Fam Med 2014;27:268–74.CrossrefWeb of SciencePubMedGoogle Scholar
Choosing Wisely. Society of General and Internal Medicine recommendation. 2013 September 12. http://www.choosingwisely.org/societies/society-of-general-internal-medicine/. Accessed: 2 Jan 2019.
Whitlock EP, Garlitz BA, Harris EL, Beil TL, Smith PR. Screening for hereditary hemochromatosis: a systematic review for the U.S. Preventive Services Task Force. Ann Intern Med 2006;145:209–23.PubMedCrossrefGoogle Scholar
Choosing Wisely. American college of medical genetics and genomics recommendations. 10 July 2015. http://www.choosingwisely.org/societies/american-college-of-medical-genetics-and-genomics/. Accessed: 2 Jan 2, 2019.
Lemke AA, Bick D, Dimmock D, Simpson P, Veith R. Perspectives of clinical genetics professionals toward genome sequencing and incidental findings: a survey study. Clin Genet 2013;84:230–6.CrossrefWeb of SciencePubMedGoogle Scholar
Kalia SS, Adelman K, Bale SJ, Chung WK, Eng C, Evans JP, et al. Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): a policy statement of the American College of Medical Genetics and Genomics. Genet Med 2017;19:249–55.Web of SciencePubMedCrossrefGoogle Scholar
MacArthur DG, Manolio TA, Dimmock DP, Rehm HL, Shendure J, Abecasis GR, et al. Guidelines for investigating causality of sequence variants in human disease. Nature 2014;508: 469–76.PubMedWeb of ScienceCrossrefGoogle Scholar
The New York Times. Kolata G. The online gene test finds a dangerous mutation. It may well be wrong. 2 July 2018. https://www.nytimes.com/2018/07/02/health/gene-testing-disease-nyt.html. Accessed: 2 Jan 2019.
Vos J, Menko FH, Oosterwijk JC, van Asperen CJ, Stiggelbout AM, Tibben A. Genetic counseling does not fulfill the counselees’ need for certainty in hereditary breast/ovarian cancer families: an explorative assessment. Psychooncology 2013;22:1167–76.CrossrefPubMedGoogle Scholar
Coupland C, Morris R, Moore M, Arthur A, Hippisley-Cox J.Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: cohort study using primary care database. Br Med J 2016;352:i1350.Web of ScienceGoogle Scholar
Andermann A, Blancquaert I, Beauchamp S, Dery V. Revisiting Wilson and Jungner in the genomic age: a review of screening criteria over the past 40 years. Bull World Health Organ 2008;86:317–9.PubMedWeb of ScienceCrossrefGoogle Scholar
About the article
Published Online: 2019-03-26
Published in Print: 2019-09-25
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.