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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 57, Issue 11


A comparison of biotin interference in routine immunoassays on the Roche Cobas 8000, Beckman Coulter DXi and Siemens Advia Centaur XPT immunoassay platforms

Shonagh Haslam
  • Corresponding author
  • Clinical Biochemistry Department, Lancashire Teaching Hospital NHS Foundation Trust, Preston PR2 9HT, UK, Phone: 01772521454, Fax: 01772522125
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jane Oakey / Andrew Brown / Susan Bradshaw / Martin Myers
  • Clinical Biochemistry Department, Lancashire Teaching Hospital NHS Foundation Trust, Preston, UK
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2019-04-16 | DOI: https://doi.org/10.1515/cclm-2019-0078


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    Peyro Saint Paul L, Debruyne D, Bernard D, Mock DM, Defer GL. Pharmacokinetics and pharmacodynamics of MD1003 (high-dose biotin) in the treatment of progressive multiple sclerosis. Expert Opin Metab Toxicol 2016;12:327–44.CrossrefWeb of ScienceGoogle Scholar

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    Trambas C, Lu Z, Yen T, Sikaris K. Characterisation of the scope and magnitude of biotin interference in susceptible Roche Elecsys competitive and sandwich immunoassays. Ann Clin Biochem 2018;55:205–15.CrossrefGoogle Scholar

  • 8.

    Piketty M, Prie D, Sedel F, Bernard D, Hercend C, Chanson P, et al. High-dose biotin therapy leading to false biochemical endocrine profiles: validation of a simple method to overcome biotin interference. Clin Chem Lab Med 2017;55:817–25.PubMedWeb of ScienceCrossrefGoogle Scholar

About the article

Received: 2019-01-23

Accepted: 2019-03-23

Published Online: 2019-04-16

Published in Print: 2019-10-25

Author contributions: SH and JO designed the study and analysed the data. SH, JO, AB and SB were involved in sample analysis and data transfer. SH wrote the first draft of the manuscript. All authors edited, reviewed and approved the final manuscript. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 57, Issue 11, Pages e287–e290, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2019-0078.

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