Belohlavek J, Dytrych V, Linhart A. Pulmonary embolism, part I: epidemiology, risk factors and risk stratification, pathophysiology, clinical presentation, diagnosis and nonthrombotic pulmonary embolism. Exp Clin Cardiol 2013;18:129–38.PubMedGoogle Scholar
Shen JH, Chen HL, Chen JR, Xing JL, Gu P, Zhu BF. Comparison of the Wells score with the revised Geneva score for assessing suspected pulmonary embolism: a systematic review and meta-analysis. J Thromb Thrombolysis 2016;41:482–92.CrossrefWeb of SciencePubMedGoogle Scholar
Pernod G, Caterino J, Maignan M, Tissier C, Kassis J, Lazarchick J, et al. D-dimer use and pulmonary embolism diagnosis in emergency units: why is there such a difference in pulmonary embolism prevalence between the United States of America and countries outside USA? PLoS One 2017;12:e0169268. Epub 2017/01/14.Web of SciencePubMedCrossrefGoogle Scholar
van Belle A, Buller HR, Huisman MV, Huisman PM, Kaasjager K, Kamphuisen PW, et al. Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography. J Am Med Assoc 2006;295:172–9.CrossrefGoogle Scholar
van der Hulle T, Tan M, den Exter PL, Mol GC, Iglesias del Sol A, van de Ree MA, et al. Selective D-dimer testing for the diagnosis of acute deep vein thrombosis: a validation study. J Thromb Haemost 2013;11:2184–6.Web of ScienceCrossrefGoogle Scholar
Khalafallah A, Jarvis C, Morse M, Albarzan AM, Stewart P, Bates G, et al. Evaluation of the innovance d-dimer assay for the diagnosis of disseminated intravascular coagulopathy in different clinical settings. Clin Appl Thromb Hemost 2014;20:91–7.Web of ScienceCrossrefGoogle Scholar
Folsom AR, Gottesman RF, Appiah D, Shahar E, Mosley TH. Plasma D-dimer and incident ischemic stroke and coronary heart disease: the atherosclerosis risk in communities study. Stroke 2016;47:18–23.CrossrefPubMedWeb of ScienceGoogle Scholar
Schuetz P, Hausfater P, Amin D, Haubitz S, Fassler L, Grolimund E, et al. Optimizing triage and hospitalization in adult general medical emergency patients: the triage project. BMC Emerg Med 2013;13:12.CrossrefPubMedGoogle Scholar
Schuetz P, Hausfater P, Amin D, Amin A, Haubitz S, Faessler L, et al. Biomarkers from distinct biological pathways improve early risk stratification in medical emergency patients: the multinational, prospective, observational TRIAGE study. Crit Care 2015;19:377.PubMedWeb of ScienceCrossrefGoogle Scholar
Eckart A, Hauser SI, Kutz A, Haubitz S, Hausfater P, Amin D, et al. Combination of the National Early Warning Score (NEWS) and inflammatory biomarkers for early risk stratification in emergency department patients: results of a multinational, observational study. Br Med J Open 2019;9:e024636.Google Scholar
Saeed K, Wilson DC, Bloos F, Schuetz P, van der Does Y, Melander O, et al. The early identification of disease progression in patients with suspected infection presenting to the emergency department: a multi-centre derivation and validation study. Crit Care 2019;23:40.PubMedWeb of ScienceCrossrefGoogle Scholar
Eckart A, Hausfater P, Amin D, Amin A, Haubitz S, Bernard M, et al. Hyponatremia and activation of vasopressin secretion are both independently associated with 30-day mortality: results of a multicenter, observational study. J Intern Med 2018;284:270–81.CrossrefWeb of SciencePubMedGoogle Scholar
Sager R, Wirz Y, Amin D, Amin A, Hausfater P, Huber A, et al. Are admission procalcitonin levels universal mortality predictors across different medical emergency patient populations? Results from the multi-national, prospective, observational TRIAGE study. Clin Chem Lab Med 2017;55:1873–80.Web of SciencePubMedGoogle Scholar
Lippi G, Bonfanti L, Saccenti C, Cervellin G. Causes of elevated D-dimer in patients admitted to a large urban emergency department. Eur J Intern Med 2014;25:45–8.CrossrefWeb of SciencePubMedGoogle Scholar
Raja AS, Greenberg JO, Qaseem A, Denberg TD, Fitterman N, Schuur JD, et al. Evaluation of patients with suspected acute pulmonary embolism: best practice advice from the Clinical Guidelines Committee of the American College of Physicians. Ann Intern Med 2015;163:701–11.CrossrefPubMedGoogle Scholar
Righini M, Van Es J, Den Exter PL, Roy PM, Verschuren F, Ghuysen A, et al. Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study. J Am Med Assoc 2014;311:1117–24.CrossrefWeb of ScienceGoogle Scholar
Righini M, Nendaz M, Le Gal G, Bounameaux H, Perrier A. Influence of age on the cost-effectiveness of diagnostic strategies for suspected pulmonary embolism. J Thromb Haemost 2007;5:1869–77.PubMedCrossrefWeb of ScienceGoogle Scholar
Douma RA, le Gal G, Sohne M, Righini M, Kamphuisen PW, Perrier A, et al. Potential of an age adjusted D-dimer cut-off value to improve the exclusion of pulmonary embolism in older patients: a retrospective analysis of three large cohorts. Br Med J 2010;340:c1475.Web of ScienceCrossrefGoogle Scholar
Jo JY, Lee MY, Lee JW, Rho BH, Choi WI. Leukocytes and systemic inflammatory response syndrome as prognostic factors in pulmonary embolism patients. BMC Pulm Med 2013;13:74.CrossrefWeb of SciencePubMedGoogle Scholar
Kayrak M, Erdogan HI, Solak Y, Akilli H, Gul EE, Yildirim O, et al. Prognostic value of neutrophil to lymphocyte ratio in patients with acute pulmonary embolism: a restrospective study. Heart Lung Circ 2014;23:56–62.PubMedCrossrefWeb of ScienceGoogle Scholar
Folsom AR, Lutsey PL, Astor BC, Cushman M. C-reactive protein and venous thromboembolism. A prospective investigation in the ARIC cohort. Thromb Haemost 2009;102:615–9.PubMedCrossrefWeb of ScienceGoogle Scholar
Rackauskiene JG, Mataciunas M, Abrutyte M, Kusner O, Danila E. Clinical significance of C reactive protein and MASTORA score in pulmonary embolism. Eur Res J 2014;44(Suppl 58):P3659.Google Scholar
Schuetz P, Beishuizen A, Broyles M, Ferrer R, Gavazzi G, Gluck EH, et al. Procalcitonin (PCT)-guided antibiotic stewardship: an international experts consensus on optimized clinical use. Clin Chem Lab Med 2019;57:1308–18.Web of SciencePubMedCrossrefGoogle Scholar
Karami-Djurabi R, Klok FA, Kooiman J, Velthuis SI, Nijkeuter M, Huisman MV. D-dimer testing in patients with suspected pulmonary embolism and impaired renal function. Am J Med 2009;122:1050–3.PubMedWeb of ScienceCrossrefGoogle Scholar
Keller K, Beule J, Balzer JO, Dippold W. Renal function as a cofactor for risk stratification and short-term outcome in acute pulmonary embolism. Exp Gerontol 2017;100:11–6.Web of ScienceCrossrefPubMedGoogle Scholar
Altinsoy B, Oz II, Ornek T, Erboy F, Tanriverdi H, Uygur F, et al. Prognostic value of renal dysfunction indicators in normotensive patients with acute pulmonary embolism. Clin Appl Thromb Hemost 2017;23:554–61.Web of SciencePubMedCrossrefGoogle Scholar
Xi X, Yang J, Wang Z, Zhu C, Li J, Liu S. [Potential utility of a renal function adjusted D-dimer cut-off value for improving the exclusion of pulmonary embolism]. Zhonghua Yi Xue Za Zhi 2015;95:2433–6.PubMedGoogle Scholar
About the article
Published Online: 2019-07-24
Published in Print: 2019-10-25
Author contributions: PS and BM conceptualized and designed the study, wrote the protocol and initiated the initial TRIAGE study. PS, MG and AV drafted the present manuscript and performed the statistical analyses. SH and AV contributed to the revision of the raw data. All authors contributed to the data acquisition, interpretation and drafting of the analyses, critical review for important content and final approval of the manuscript. PS had full access to all data in the study and takes responsibility for the integrity of the work and the accuracy of the data analysis. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Conflict of interest: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.