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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Volume 57, Issue 2

Issues

Evaluation of a rapid centrifugation step (4500 g for 2 min) in coagulation assays to monitor direct oral anticoagulants

Justine Brulé
  • Service d’hématologie biologique, CHU Clermont-Ferrand, Hôpital Estaing, Clermont-Ferrand, France
  • Other articles by this author:
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/ Solène Revy
  • Service d’hématologie biologique, CHU Clermont-Ferrand, Hôpital Estaing, Clermont-Ferrand, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Charlotte Faure
  • Service d’hématologie biologique, CHU Clermont-Ferrand, Hôpital Estaing, Clermont-Ferrand, France
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/ Romain Eschalier
  • Service de cardiologie et maladies vasculaires, CHU Clermont-Ferrand, Hôpital Gabriel Montpied, Clermont-Ferrand, France
  • Other articles by this author:
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/ Grégoire Massoullié
  • Service de cardiologie et maladies vasculaires, CHU Clermont-Ferrand, Hôpital Gabriel Montpied, Clermont-Ferrand, France
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/ Thomas Tassin
  • Service d’hématologie biologique, CHU Clermont-Ferrand, Hôpital Estaing, Clermont-Ferrand, France
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/ Bruno Pereira
  • Service de biostatistiques, direction de la recherche clinique et de l’innovation, CHU Clermont-Ferrand, Clermont-Ferrand, France
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/ Thomas Sinegre
  • Service d’hématologie biologique, CHU Clermont-Ferrand, Hôpital Estaing, Clermont-Ferrand, France
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/ Aurélien LebretonORCID iD: https://orcid.org/0000-0002-1650-0427
Published Online: 2018-07-23 | DOI: https://doi.org/10.1515/cclm-2018-0410

References

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    Boissier E, Sévin-Allouet M, Le Thuaut A, De Gaalon S, Trossaërt M, Rozec B, et al. A 2-min at 4500 g rather than a 15-min at 2200 g centrifugation does not impact the reliability of 10 critical coagulation assays. Clin Chem Lab Med 2017;55:e118–21.Web of ScienceCrossrefGoogle Scholar

  • 2.

    Douxfils J, Ageno W, Samama C-M, Lessire S, Ten Cate H, Verhamme P, et al. Laboratory testing in patients treated with direct oral anticoagulants: a practical guide for clinicians. J Thromb Haemost 2018;16:209–19.PubMedCrossrefWeb of ScienceGoogle Scholar

  • 3.

    Adcock Funk D, Hoefner D, Kottke-Marchant K, Marlar R, Szamosi D, Warunek D. Collection, transport and processing of blood specimens for testing plasma-based coagulation assays and molecular hemostasis assays; approved guideline, 5th ed. Wayne PA: Institute CLS, CLSI document H21-A5, 2008.Google Scholar

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    Mackie I, Cooper P, Lawrie A, Kitchen S, Gray E, Laffan M, et al. Guidelines on the laboratory aspects of assays used in haemostasis and thrombosis. Int J Lab Hematol 2013;35:1–13.Web of ScienceCrossrefGoogle Scholar

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    Groupe de travail du GFTH. Révision des recommandations pré- analytiques en hémostase. 2015. Available at: http://site.geht.org.

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    Pappas AA, Palmer SK, Meece D, Fink LM. Rapid preparation of plasma for coagulation testing. Arch Pathol Lab Med 1991;115:816–7.PubMedGoogle Scholar

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    Nelson S, Pritt A, Marlar RA. Rapid preparation of plasma for ‘Stat’ coagulation testing. Arch Pathol Lab Med 1994;118: 175–6.PubMedGoogle Scholar

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    Suchsland J, Friedrich N, Grotevendt A, Kallner A, Lüdemann J, Nauck M, et al. Optimizing centrifugation of coagulation samples in laboratory automation. Clin Chem Lab Med 2014;52:1187–91.Web of SciencePubMedGoogle Scholar

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    Pfaefflin A, Schuster K, Braun R. Short centrifugation to ameliorate turn-around-time in routine coagulation testing. Clin Lab 2017;63:1945–7.Web of SciencePubMedGoogle Scholar

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    Lippi G, Favaloro EJ. Recent guidelines and recommendations for laboratory assessment of the direct oral anticoagulants (DOACs): is there consensus? Clin Chem Lab Med 2015;53:185–97.PubMedWeb of ScienceGoogle Scholar

About the article

Corresponding author: Dr. Aurélien Lebreton, Service d’hématologie biologique, CHU Clermont-Ferrand, Hôpital Estaing, Clermont-Ferrand, France, Phone: +33 4 73 750 200, Fax: +33 4 73 750 215

aJustine Brulé and Solène Revy contributed equally to this work.


Received: 2018-04-20

Accepted: 2018-07-03

Published Online: 2018-07-23

Published in Print: 2018-12-19


Author contributions: J. Brule, S. Revy, C. Faure and T. Tassin performed all the laboratory experiments, processed the data and wrote the manuscript. R. Eschalier and G. Massoulié screened and recruited patients. B. Pereira performed the statistical analysis. T. Sinegre revised the manuscript and added comments. A. Lebreton designed the study, processed the data and wrote the manuscript. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: This study was supported by a grant of Clermont-Ferrand University Hospital.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 57, Issue 2, Pages e37–e40, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2018-0410.

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