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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Volume 57, Issue 6

Issues

A challenging case: highly variable TSH in a mother and her two children

Sandrine Donadio-Andrei / Nathalie Hubert / Véronique Raverot
  • Laboratoire de Biochimie, Centre de Biologie Est, Groupement hospitalier Est, Bron cedex, France
  • Société Française de Médecine Nucléaire, Groupe de Biologie Spécialisée, Centre Antoine Béclère, Paris, France
  • Hospices Civils de Lyon, Lyon, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Emmanuelle Plantin-Carrenard / Elisabetta Kuczewski / Anne Charrié
  • Société Française de Médecine Nucléaire, Groupe de Biologie Spécialisée, Centre Antoine Béclère, Paris, France
  • Hospices Civils de Lyon, Lyon, France
  • Laboratoire de Biochimie et biologie moléculaire, Centre de Biologie Sud Centre Hospitalier Lyon Sud, Pierre Bénite Cedex, France
  • Inserm UMR-1060, Laboratoire CarMeN, Oullins cedex, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Catherine Ronin / Anne-Sophie Gauchez
  • Société Française de Médecine Nucléaire, Groupe de Biologie Spécialisée, Centre Antoine Béclère, Paris, France
  • UMR-S INSERM 1039, Grenoble, France
  • Laboratoire du Service de Médecine Nucléaire, Centre Hospitalier Métropole Savoie, Chambéry, France
  • Pôle de Biologie, Centre Hospitalier et Universitaire de Grenoble, Grenoble, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Karim Chikh
  • Corresponding author
  • Laboratoire de Biochimie et biologie moléculaire, Centre de Biologie Sud Centre Hospitalier Lyon Sud, 69495 Pierre Bénite Cedex, France
  • Société Française de Médecine Nucléaire, Groupe de Biologie Spécialisée, Centre Antoine Béclère, 45 rue des Saints Pères, 75270 Paris, France
  • Hospices Civils de Lyon, 69002 Lyon, France
  • Inserm UMR-1060, Laboratoire CarMeN, Université Lyon 1, 165 Chemin du Grand Revoyet, BP12, 69921 Oullins cedex, France, Phone: (+33) 4 78 86 21 69/ (+33) 6 23 90 08 92
  • Email
  • Other articles by this author:
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Published Online: 2018-10-31 | DOI: https://doi.org/10.1515/cclm-2018-0871

References

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    Donadio-Andréi S, Chikh K, Heuclin C, Kuczewski E, Charrié A, Gauchez AS, et al. Variability among TSH measurements can be reduced by combining a glycoengineered calibrator to epitope-defined immunoassays. Eur Thyroid J 2017;6:3–11.PubMedWeb of ScienceCrossrefGoogle Scholar

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About the article

Received: 2018-08-13

Accepted: 2018-09-23

Published Online: 2018-10-31

Published in Print: 2019-05-27


Author contributions: NH as a pediatrician has managed thyroid test abnormalities of the family studied here and has sent the samples to AC and KC. EPC has managed thyroid test. KC, AC, SDA, EK, ASG and CR have designed biochemical investigations. SDA has performed biochemical tests. KC has performed bioactivity tests. VR has performed gel chromatography. KC, AC, ASG, CR and SDA analyzed and interpreted the data. ASG, CR, KC and SDA wrote the first drafts of the manuscript, and all authors read and commented the manuscript. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: This work was supported by public funds (salaries of NH, VV, EPC, EK, AC, ASG and KC and reagents by hospitals) and by private funds (salaries of SDA and CR).

Employment or leadership: The work presented in this publication is not patented. CR is a founder and shareholder of Siamed’Xpress, and SDA is a senior manager of the company. The biotech company holds two patents, one on methods for producing sialylated therapeutic proteins (PCT/EP2014/001904) of which CR is inventor and one on the screening of glycoform-specific antibodies (PCT/EP2005/001160) of which SDA and CR are coinventors.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 57, Issue 6, Pages e114–e117, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2018-0871.

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