Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

See all formats and pricing
More options …
Volume 57, Issue 6


Hemoglobin variants found in relation to HbA1c testing: high occurrence of Hb Athens-Georgia in the Northern Jutland, Denmark

Jan Nybo / Anette Tarp Hansen / Jesper Brix Petersen / Axel Brock
Published Online: 2018-10-08 | DOI: https://doi.org/10.1515/cclm-2018-0902


  • 1.

    Birgens H, Ljung R. The thalassaemia syndromes. Scand J Clin Lab Invest 2007;67:11–26.CrossrefPubMedWeb of ScienceGoogle Scholar

  • 2.

    HbVar: A Database of Human Hemoglobin Variants and Thalassemias. Available at: http://globin.bx.psu.edu/cgi-bin/hbvar/counter. Accessed: 8 Jan 2018.

  • 3.

    Little RR, La’ulu SL, Hanson SE, Rohlfing CL, Schmidt RL. Effects of 49 different rare Hb variants on HbA1c measurement in eight methods. J Diabetes Sci Technol 2015;9:849–56.PubMedCrossrefGoogle Scholar

  • 4.

    Rohlfing C, Hanson S, Weykamp C, Siebelder C, Higgins T, Molinaro R, et al. Effects of hemoglobin C, D, E and S traits on measurements of hemoglobin A1c by twelve methods. Clin Chim Acta 2016;455:80–3.CrossrefGoogle Scholar

  • 5.

    Rhea JM, Molinaro R. Pathology Consultation on HbA1c methods and interferences. Am J Clin Pathol 2014;141:5–16.PubMedCrossrefGoogle Scholar

  • 6.

    Jaisson S, Leroy N, Meurice J, Guillard E, Gillery P. First evaluation of Capillarys 2 Flex Piercing® (Sebia) as a new analyzer for HbA1c assay by capillary electrophoresis. Clin Chem Lab Med 2012;50:1769–75.PubMedGoogle Scholar

  • 7.

    van Zwieten R, Veldthuis M, Delzenne B, Berghuis J, Groen J, Ait Ichou F, et al. Hemoglobin analyses in the Netherlands reveal more than 80 different variants including six novel ones. Hemoglobin 2014;38:1–7.CrossrefWeb of SciencePubMedGoogle Scholar

  • 8.

    Peeters B, Brandt I, Desmet K, Harteveld CL, Kieffer D. Hb Melusine and Hb Athens-Georgia: potentially underreported in the Belgian population? Four cases demonstrating the lack of detection using common CE-HPLC methods either for glycated hemoglobin HbA1c analysis or Hb variant screening. Acta Clin Belg 2016;71:458–61.CrossrefPubMedGoogle Scholar

  • 9.

    Blanke S, Johnsen A, Wimberley PD. HB Athens-Georgia [β40(C6)ARG→LYS] in a Danish family. Hemoglobin 1989;13: 181–3.CrossrefGoogle Scholar

  • 10.

    Strickland SW, Campbell ST, Little RR, Bruns DE, Bazydlo LA. Prevalence of rare hemoglobin variants identified during measurements of HbA1c by capillary electrophoresis. Clin Chem 2017;63:1901–2.CrossrefGoogle Scholar

About the article

Corresponding author: Jan Nybo, MD, Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark, Phone: +45 23 99 41 12

Received: 2018-06-14

Accepted: 2018-09-10

Published Online: 2018-10-08

Published in Print: 2019-05-27

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 57, Issue 6, Pages e108–e110, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2018-0902.

Export Citation

©2019 Walter de Gruyter GmbH, Berlin/Boston.Get Permission

Comments (0)

Please log in or register to comment.
Log in