Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

See all formats and pricing
More options …
Volume 57, Issue 7


An unexpectedly prolonged severe hyperbilirubinemia in a patient with pre-existing hepatitis A: a role of genetic predisposition?

Felicia Stefania Falvella
  • Corresponding author
  • UOC Patologia Clinica, ASST Fatebenefratelli-Sacco, Via Giovanni Battista Grassi, 74, 20157, Milan, Italy
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Elena Angeli / Laura Cordier / Emilio Clementi
  • Dipartimento di Scienze Biomediche e Cliniche ‘Luigi Sacco’, Università degli Studi, Milan, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mauro Panteghini
  • Dipartimento di Scienze Biomediche e Cliniche ‘Luigi Sacco’, Università degli Studi, Milan, Italy
  • UOC Patologia Clinica, ASST Fatebenefratelli-Sacco, Milan, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2018-11-13 | DOI: https://doi.org/10.1515/cclm-2018-0962


  • 1.

    Shin EC, Jeong SH. Natural history, clinical manifestations, and pathogenesis of hepatitis A. Cold Spring Harb Perspect Med 2018;8: pii:a031708.Web of ScienceCrossrefGoogle Scholar

  • 2.

    Panteghini M, Bais R. Serum enzymes. In: Rifai N, Horvath AR, Wittwer CT, editors. Tietz textbook of clinical chemistry and molecular diagnostics, 6th ed. St. Louis, MO: Elsevier Saunders, 2018:404–34.Google Scholar

  • 3.

    Keppler D. The roles of MRP2, MRP3, OATP1B1, and OATP1B3 in conjugated hyperbilirubinemia. Drug Metab Dispos 2014;42:561–5.CrossrefPubMedWeb of ScienceGoogle Scholar

  • 4.

    Sticova E, Jirsa M. New insights in bilirubin metabolism and their clinical implications. World J Gastroenterol 2013;19:6398–407.CrossrefWeb of SciencePubMedGoogle Scholar

  • 5.

    Bosma PJ, Chowdhury JR, Bakker C, Gantla S, de Boer A, Oostra BA, et al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert’s syndrome. N Engl J Med 1995;333:1171–5.PubMedCrossrefGoogle Scholar

  • 6.

    Werk AN, Bruckmueller H, Haenisch S, Cascorbi I. Genetic variants may play an important role in mRNA-miRNA interaction: evidence for haplotype-dependent downregulation of ABCC2 (MRP2) by miRNA-379. Pharmacogenet Genomics 2014;24:283–91.Web of ScienceCrossrefPubMedGoogle Scholar

  • 7.

    Ripperger A, Benndorf RA. The C421A (Q141K) polymorphism enhances the 3′-untranslated region (3′-UTR)-dependent regulation of ATP-binding cassette transporter ABCG2. Biochem Pharmacol 2016;104:139–47.CrossrefWeb of SciencePubMedGoogle Scholar

  • 8.

    Lee HH, Ho RH. Interindividual and interethnic variability in drug disposition: polymorphisms in organic anion transporting polypeptide 1B1 (OATP1B1; SLCO1B1). Br J Clin Pharmacol 2017;83:1176–84.CrossrefWeb of SciencePubMedGoogle Scholar

  • 9.

    Krawczyk M, Grünhage F, Langhirt M, Bohle RM, Lammert F. Prolonged cholestasis triggered by hepatitis A virus infection and variants of the hepatocanalicular phospholipid and bile salt transporters. Ann Hepatol 2012;11:710–4.PubMedGoogle Scholar

  • 10.

    Slachtova L, Seda O, Behunova J, Mistrik M, Martasek P. Genetic and biochemical study of dual hereditary jaundice: Dubin-Johnson and Gilbert’s syndromes. Haplotyping and founder effect of deletion in ABCC2. Eur J Hum Genet 2016;24:704–9. Erratum in: Eur J Hum Genet 2016;24:1515.CrossrefPubMedWeb of ScienceGoogle Scholar

About the article

Received: 2018-08-31

Accepted: 2018-10-17

Published Online: 2018-11-13

Published in Print: 2019-06-26

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 57, Issue 7, Pages e145–e148, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2018-0962.

Export Citation

©2018 Walter de Gruyter GmbH, Berlin/Boston.Get Permission

Comments (0)

Please log in or register to comment.
Log in