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Licensed Unlicensed Requires Authentication Published by De Gruyter November 9, 2018

Free PAPP-A as a biomarker: heparin-induced release is not related to coronary atherosclerotic burden

  • Emilia Tuunainen EMAIL logo , Teemu Maaniitty , Juhani Knuuti , Kim Pettersson , Saara Wittfooth and Antti Saraste

Corresponding author: Emilia Tuunainen, M.Sc., Department of Biochemistry/Biotechnology, University of Turku, Kiinamyllynkatu 10, Medisiina D, 6th Floor, FI-20520 Turku, Finland, Phone: +358 29 450 4596

Acknowledgments

We gratefully acknowledge HyTest Ltd and Kaivogen Oy for their reagent support. We thank Heli Louhi for her aid in recruiting patients and taking blood samples. We thank Tatu Hirvonen for his excellent technical assistance.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This work was supported by The Academy of Finland Centre of Excellence on Cardiovascular and Metabolic Disease, Helsinki, Finland (AS and JK), the Finnish Foundation for Cardiovascular Research (AS and JK) and University of Turku Doctoral Programme of Clinical Research (ET). For TM, KP and SW none declared.

  3. Employment or leadership: None declared.

  4. Honorarium: Outside the submitted work consultancy for GE Healthcare, Novartis and Astra Zeneca (AS), payment for lectures from Bayer, Abbott and Actelion (AS) and personal fees from Astra Zeneca (JK). For ET, TM, KP and SW none declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

References

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Received: 2018-09-27
Accepted: 2018-10-18
Published Online: 2018-11-09
Published in Print: 2019-06-26

©2018 Walter de Gruyter GmbH, Berlin/Boston

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