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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Volume 57, Issue 7

Issues

Stability of cannabinoids in cannabis FM1 flowering tops and oil preparation evaluated by ultra-high performance liquid chromatography tandem mass spectrometry

Roberta Pacifici / Emilia Marchei / Francesco Salvatore
  • Agenzia Industrie e Difesa, Stabilimento Chimico Farmaceutico Militare (Military Pharmaceutical Chemical Works of Florence), Florence, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Luca Guandalini
  • Agenzia Industrie e Difesa, Stabilimento Chimico Farmaceutico Militare (Military Pharmaceutical Chemical Works of Florence), Florence, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Francesco Paolo Busardò / Simona Pichini
  • Corresponding author
  • National Centre on Addiction and Doping, Istituto Superiore di Sanità, V.le Regina Elena 299, 00161 Rome, Italy, Phone: +390649906545, Fax: +390649902016
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2018-11-26 | DOI: https://doi.org/10.1515/cclm-2018-1145

References

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    “Uso medico della cannabis – Cenni generali”. http://www.salute.gov.it/portale/temi/p2_6.jsp?lingua=italiano&id=4587&area=sostanzeStupefacenti&menu=vuoto. Accessed: 22 Oct 2018.

  • 2.

    Pacifici R, Marchei E, Salvatore F, Guandalini L, Busardò FP, Pichini S. Evaluation of cannabinoids concentration and stability in standardized preparations of cannabis tea and cannabis oil by ultra-high performance liquid chromatography tandem mass spectrometry. Clin Chem Lab Med 2017;55:1555–63.Web of SciencePubMedGoogle Scholar

  • 3.

    Pacifici R, Marchei E, Salvatore F, Guandalini L, Busardò FP, Pichini S. Evaluation of long-term stability of cannabinoids in standardized preparations of cannabis flowering tops and cannabis oil by ultra-high-performance liquid chromatography tandem mass spectrometry. Clin Chem Lab Med 2018;56:94–6.Web of SciencePubMedCrossrefGoogle Scholar

  • 4.

    Website: Decreto 9 novembre 2015: Funzioni di Organismo statale per la cannabis previsto dagli articoli 23 e 28 della convenzione unica sugli stupefacenti del 1961, come modificata nel 1972. Available at: http://www.gazzettaufficiale.it/eli/ id/2015/11/30/15A08888/sg;jsessionid=p1rnwNujUKlqQ5azhA Q95A__.ntc-as3-guri2a. Accessed 30 October 2018.

  • 5.

    De Backer B, Debrus B, Lebrun P, Theunis L, Dubois N, Decock L, et al. Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material. J Chromatogr B Anal Technol Biomed Life Sci 2009;877:4115–24.CrossrefGoogle Scholar

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    Trofin IG, Dabija G, Váireanu DI, Filipescu L. The influence of long-term storage conditions on the stability of cannabinoids derived from cannabis resin. Rev Chim 2012;63:422–7Google Scholar

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    Trofin IG, Dabija G, Váireanu DI, Filipescu L. Long term storage and cannabis oil stability. Rev Chim 2012;63:293–7Google Scholar

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    Taschwer M, Schmid MG. Determination of the relative percentage distribution of THCA and Δ(9)-THC in herbal cannabis seized in Austria – impact of different storage temperatures on stability. Forensic Sci Int 2015;254:167–71.PubMedCrossrefWeb of ScienceGoogle Scholar

  • 9.

    Calvi L, Pentimalli D, Panseri S, Giupponi L, Gelmini F, Beretta G, et al. Comprehensive quality evaluation of medical Cannabis sativa L. inflorescence and macerated oils based on HS-SPME coupled to GC-MS and LC-HRMS (q-exactive orbitrap®) approach. J Pharm Biomed Anal 2018;150:208–19.Web of SciencePubMedCrossrefGoogle Scholar

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    Pichini S, Pacifici R, Busardò FP, Tagliabracci A, Giorgetti R. The challenge of clinical application of FM2 cannabis oil produced in Italy for the treatment of neuropathic pain. Eur Rev Med Pharmacol Sci 2018;22:863–5.PubMedGoogle Scholar

  • 11.

    Swift W, Wong A, Li KM, Arnold JC, McGregor IS. Analysis of cannabis seizures in NSW, Australia: cannabis potency and cannabinoid profile. PLoS One 2013;8:e70052.Web of SciencePubMedCrossrefGoogle Scholar

About the article

Received: 2018-10-23

Accepted: 2018-11-02

Published Online: 2018-11-26

Published in Print: 2019-06-26


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 57, Issue 7, Pages e165–e168, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2018-1145.

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