Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

See all formats and pricing
More options …
Volume 57, Issue 9


Lesson from inappropriate TSH-receptor antibody measurement in hypothyroidism: case series and literature review

Arnaud JanninORCID iD: https://orcid.org/0000-0002-6031-4816 / Lucas Peltier
  • CHU Rennes, Department of Biochemistry, Rennes, France
  • University of Rennes 1, Faculty of Medicine, Rennes, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Michèle d’Herbomez / Frédérique Defrance / Sophie Marcelli / Adrien Ben Hamou / Linda Humbert / Jean-Louis Wémeau / Marie-Christine Vantyghem / Stéphanie Espiard
Published Online: 2019-03-08 | DOI: https://doi.org/10.1515/cclm-2019-0090


  • 1.

    Garber J, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract 2012;18:988–1028.Web of ScienceCrossrefGoogle Scholar

  • 2.

    McLachlan SM, Rapoport B. Thyrotropin-blocking autoantibodies and thyroid stimulating autoantibodies: potential mechanisms involved in the pendulum swinging from hypothyroidism to hyperthyroidism or vice versa. Thyroid 2013;23:14–24.PubMedWeb of ScienceCrossrefGoogle Scholar

  • 3.

    Diana T, Krause J, Olivo PD, König J, Kanitz M, Decallonne B, et al. Prevalence and clinical relevance of thyroid stimulating hormone receptor-blocking antibodies in autoimmune thyroid disease. Clin Exp Immunol 2017;189:304–9.CrossrefPubMedWeb of ScienceGoogle Scholar

  • 4.

    Diana T, Olivo PD, Kahaly GJ. Thyrotropin receptor blocking antibodies. Horm Metab Res 2018;50:853–62.CrossrefPubMedWeb of ScienceGoogle Scholar

  • 5.

    Massart C, Orgiazzi J, Maugendre D. Clinical validity of a new commercial method for detection of TSH-receptor bindingantibodies in sera from patients with Graves’ disease treated with antithyroid drugs. Clin Chim Acta 2001;304:39–47.CrossrefPubMedGoogle Scholar

  • 6.

    Takasu N, Yamada T, Takasu M, Komiya I, Nagasawa Y, Asawa T, et al. Disappearance of thyrotropin-blocking antibodies and spontaneous recovery from hypothyroidism in autoimmune thyroiditis. N Engl J Med 1992;326:513–8.CrossrefPubMedGoogle Scholar

  • 7.

    Sato K, Okamura K, Yoshinari M, Ikenoue H, Kuroda T, Torisu M, et al. Goitrous hypothyroidism with blocking or stimulating thyrotropin binding inhibitor immunoglobulins. J Clin Endocrinol Metab 1990;71:855–60.PubMedCrossrefGoogle Scholar

  • 8.

    Yoshida S, Takamatsu J, Kuma K, Ohsawa N. Thyroid-stimulating antibodies and thyroid stimulation-blocking antibodies during the pregnancy and postpartum period: a case report. Thyroid 1992;2:27–30.CrossrefPubMedGoogle Scholar

  • 9.

    Carlé A, Pedersen IB, Knudsen N, Perrild H, Ovesen L, Jørgensen T, et al. Thyroid volume in hypothyroidism due to autoimmune disease follows a unimodal distribution: evidence against primary thyroid atrophy and autoimmune thyroiditis being distinct diseases. J Clin Endocrinol Metab 2009;94:833–9.Web of ScienceCrossrefGoogle Scholar

  • 10.

    Daikeler T, Labopin M, Di Gioia M, Abinun M, Alexander T, Miniati I, et al. Secondary autoimmune diseases occurring after HSCT for an autoimmune disease: a retrospective study of the EBMT Autoimmune Disease Working Party. Blood 2011;118:1693–8.Web of SciencePubMedCrossrefGoogle Scholar

About the article

Corresponding authors: Marie-Christine Vantyghem, MD, PhD, Department of Endocrinology, Diabetology and Metabolism, CHU Lille, F-59000, Lille, France; and Dr. Stéphanie Espiard, MD, PhD, Department of Endocrinology, Diabetology and Metabolism, CHU Lille, 1, Rue Polonovski, 59037 Lille, France, Phone: +33 (0)3 2 0444 535, Fax: +33 (0)3 2 0446 985

Received: 2019-01-26

Accepted: 2019-02-06

Published Online: 2019-03-08

Published in Print: 2019-08-27

Author contributions: AJ and SE wrote the paper, collected data and searched the literature. MD and LP performed the biological assays. SE, LG, FD, SM, JLW, and MCV examined the patients. SE and MCV supervised the work. All authors interpreted the data and contributed to the final version of the manuscript. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Author disclosure statement: The authors have nothing to disclose concerning this study.

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 57, Issue 9, Pages e218–e221, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2019-0090.

Export Citation

©2019 Walter de Gruyter GmbH, Berlin/Boston.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Somayeh Bahrami, Seyyede Sedighe Mousavi, Ali Reza Alborzi, Godratollah Mohammadi, and Mehdi Namavari
Veterinary Parasitology, 2019, Volume 273, Page 5

Comments (0)

Please log in or register to comment.
Log in