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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
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1437-4331
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Volume 58, Issue 1

Issues

Plasma creatinine medians from patients partitioned by gender and age used as a tool for assessment of analytical stability at different concentrations

Steen Ingemann Hansen
  • Corresponding author
  • Department of Clinical Biochemistry, Nordsjællands Hospital, University of Copenhagen, Dyrehavevej 29, 3400 Hillerød, Denmark, Phone: +004548294156, Fax: +004548294184
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Per Hyltoft Petersen
  • Department of Clinical Biochemistry, Nordsjællands Hospital, University of Copenhagen, Hillerød, Denmark
  • Norwegian Quality Improvement of Laboratory Examinations (NOKLUS), Haraldsplass Deaconess Hospital, Bergen, Norway
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Flemming Lund
  • Department of Clinical Biochemistry, Nordsjællands Hospital, University of Copenhagen, Hillerød, Denmark
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Callum G. Fraser
  • Centre for Research into Cancer Prevention and Screening, University of Dundee, Dundee, Scotland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2019-08-05 | DOI: https://doi.org/10.1515/cclm-2019-0334

Abstract

Background

Monthly medians of patient results are useful in assessment of analytical quality in medical laboratories. Separate medians by gender makes it possible to generate two independent estimates of contemporaneous errors. However, for plasma creatinine, reference intervals (RIs) are different by gender and also higher over 70 years of age.

Methods

Daily, weekly and monthly patient medians were calculated from the raw data of plasma creatinine concentrations for males between 18 and 70 years, males >70 years, females between 18 and 70 years and females >70 years.

Results

The medians of the four groups were all closely associated, with similar patterns. The mean of percentage bias from each group defined the best estimate of bias. The maximum half-range (%) of the bias evaluations provided an estimate of the uncertainty comparable to the analytical performance specifications: thus, bias estimates could be classified as optimum, desirable or minimum quality.

Conclusions

Medians by gender and age are useful in assessment of analytical stability for plasma creatinine concentration ranging from 60 to 90 μmol/L. The daily medians are valuable in rapid detection of large systematic errors, the weekly medians in detecting minor systematic errors and monthly medians in assessment of long-term analytical stability.

Keywords: analytical stability; medians of plasma creatinine; partitioning by gender and age; percentage bias; raw data for plasma creatinine

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About the article

Received: 2019-03-26

Accepted: 2019-07-12

Published Online: 2019-08-05

Published in Print: 2019-12-18


Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organisation(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 58, Issue 1, Pages 69–76, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2019-0334.

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